International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(4), С. 2005 - 2005
Опубликована: Фев. 7, 2024
Polysaccharides
are
one
of
the
main
active
ingredients
Polygonum
sibiricum
(PS),
which
is
a
food
and
medicine
homolog
used
throughout
Chinese
history.
The
antidepressant-like
effects
PSP
its
underlying
mechanisms
remain
elusive,
especially
regulation
microglial
polarization.
current
study
determined
chemical
composition
structural
characteristics
PSP.
Then,
chronic
unpredictable
mild
stress
(CUMS)
procedure
was
carried
out
on
zebrafish
for
5
weeks,
immersed
9
days
(1
h/d).
body
weight
monitored,
behavioral
tests,
including
novel
tank
test
light
dark
test,
were
performed
to
evaluate
function
hypothalamic-pituitary-interrenal
(HPI)
axis,
levels
peripheral
inflammation,
neuronal
blood–brain
barrier
damage
in
mesencephalon
telencephalon,
mRNA
expression
M1/M2
phenotype
genes
brain
examined.
samples
had
typical
polysaccharides,
consisting
glucose,
mannose,
galactose,
with
an
average
Mw
20.48
kDa,
presented
porous
agglomerated
morphologies.
Compared
untreated
zebrafish,
depression-like
behaviors
CUMS-induced
significantly
attenuated.
decreased
cortisol
pro-inflammatory
cytokines
increased
anti-inflammatory
depressive
zebrafish.
Furthermore,
remarkably
reversed
telencephalon
brain.
These
findings
indicated
that
related
altering
HPI
axis
hyperactivation,
suppressing
inhibiting
neuroinflammation
induced
by
microglia
modulating
provides
foundations
future
examinations
functional
foods
emotional
regulation.
Food & medicine homology.,
Год журнала:
2024,
Номер
2(1), С. 9420028 - 9420028
Опубликована: Сен. 6, 2024
Edible
mushrooms
are
esteemed
worldwide
for
their
significant
contributions
to
food,
medicine,
and
economy.
Post-harvest
edible
vulnerable
mechanical
damage,
microbial
infection,
discoloration
due
inadequate
preservation
techniques.
This
review
aims
systematically
examine
the
current
state
of
postharvest
techniques
mushrooms.
Firstly,
this
presents
an
overview
physiological
changes
that
occur
in
after
harvesting,
encompassing
water
loss,
weight
morphological
color
alterations,
nutrient
flavor
depletion,
susceptibility.
Subsequently,
outlines
common
mushrooms,
including
low-temperature
storage,
air-conditioned
radiation,
plasma
treatment,
coatings,
with
brief
descriptions
application
cases.
Lastly,
future
direction
development
technologies
is
envisioned.
seeks
serve
as
a
reference
mushroom
industry
stimulate
further
Journal of Integrative Neuroscience,
Год журнала:
2024,
Номер
23(12)
Опубликована: Дек. 24, 2024
The
coexistence
of
anxiety
or
depression
with
coronary
heart
disease
(CHD)
is
a
significant
clinical
challenge
in
cardiovascular
medicine.
Recent
studies
have
indicated
that
hypothalamic-pituitary-adrenal
(HPA)
axis
activity
could
be
promising
focus
understanding
and
addressing
the
development
treatments
for
comorbid
CHD
depression.
HPA
helps
to
regulate
levels
inflammatory
factors,
thereby
reducing
oxidative
stress
damage,
promoting
platelet
activation,
stabilizing
gut
microbiota,
which
enhance
survival
regeneration
neurons,
endothelial
cells,
other
cell
types,
leading
neuroprotective
cardioprotective
benefits.
This
review
addresses
relevance
nervous
systems,
as
well
latest
research
advancements
regarding
its
mechanisms
action.
discussion
includes
detailed
function
regulating
processes
mentioned.
Above
all,
it
summarizes
therapeutic
potential
biomarker
atherosclerotic
combined
