The Nexus Between Traditional Chinese Medicine and Immunoporosis: Implications in the Treatment and Management of Osteoporosis DOI
Xiaolei Ding, Jie Yang,

Yuchi Wei

и другие.

Phytotherapy Research, Год журнала: 2024, Номер unknown

Опубликована: Дек. 3, 2024

ABSTRACT Osteoporosis (OP) is a globally prevalent bone disease characterized by reduced mass and heightened fracture risk, posing significant health economic challenge to aging societies worldwide. Osteoimmunology—an emerging field of study—investigates the intricate relationship between skeletal immune systems, providing insights into system's impact on progression. Recent research has demonstrated essential roles played various cells (T cells, B macrophages, dendritic mast granulocytes, innate lymphoid cells) in regulating metabolism, homeostasis, formation, remodeling through interactions with osteoclasts (OC) osteoblasts (OB). These findings underscore that osteoimmunology provides an theoretical framework for understanding pathogenesis disorders, including OP. Traditional Chinese medicine (TCM) its active ingredients have clinical value OP treatment. Unfortunately, despite their striking multieffect pathways pharmacological field, current not yet summarized them comprehensive detailed manner respect interventional diseases, especially Consequently, this review addresses recent studies mechanisms which communication molecules contribute development. Additionally, it explores potential therapeutic benefits TCM components treating from perspective osteoimmunology. The objective provide enhances immune‐related diseases facilitate development novel strategies.

Язык: Английский

Sinomenine-glycyrrhizic acid self-assembly enhanced the anti-inflammatory effect of sinomenine in the treatment of rheumatoid arthritis DOI
Haixu Jiang, Qingyi Lu,

Xuemei Huang

и другие.

Journal of Controlled Release, Год журнала: 2025, Номер unknown, С. 113718 - 113718

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0
Ganlu Formula ethyl acetate extract (GLEE) blocked the development of experimental arthritis by inhibiting NLRP3 activation and reducing M1 type macrophage polarization DOI
Shijie Zhang,

Bao Hou,

Anjing Xu

и другие.

Journal of Ethnopharmacology, Год журнала: 2024, Номер 332, С. 118377 - 118377

Опубликована: Май 22, 2024

Язык: Английский

Процитировано

3
Sinomenine Alleviates Rheumatoid Arthritis by Suppressing the PI3K-Akt Signaling Pathway, as Demonstrated Through Network Pharmacology, Molecular Docking, and Experimental Validation DOI Creative Commons
Qingyang Liu, Jian Wang,

Chunhui Ding

и другие.

Drug Design Development and Therapy, Год журнала: 2024, Номер Volume 18, С. 3523 - 3545

Опубликована: Авг. 1, 2024

Sinomenine (SIN) is commonly used in Traditional Chinese Medicine (TCM) as a respected remedy for rheumatoid arthritis (RA). Nevertheless, the therapeutic mechanism of SIN RA remains incompletely understood. This study aimed to delve into molecular treatment RA.

Язык: Английский

Процитировано

2
The Nexus Between Traditional Chinese Medicine and Immunoporosis: Implications in the Treatment and Management of Osteoporosis DOI
Xiaolei Ding, Jie Yang,

Yuchi Wei

и другие.

Phytotherapy Research, Год журнала: 2024, Номер unknown

Опубликована: Дек. 3, 2024

ABSTRACT Osteoporosis (OP) is a globally prevalent bone disease characterized by reduced mass and heightened fracture risk, posing significant health economic challenge to aging societies worldwide. Osteoimmunology—an emerging field of study—investigates the intricate relationship between skeletal immune systems, providing insights into system's impact on progression. Recent research has demonstrated essential roles played various cells (T cells, B macrophages, dendritic mast granulocytes, innate lymphoid cells) in regulating metabolism, homeostasis, formation, remodeling through interactions with osteoclasts (OC) osteoblasts (OB). These findings underscore that osteoimmunology provides an theoretical framework for understanding pathogenesis disorders, including OP. Traditional Chinese medicine (TCM) its active ingredients have clinical value OP treatment. Unfortunately, despite their striking multieffect pathways pharmacological field, current not yet summarized them comprehensive detailed manner respect interventional diseases, especially Consequently, this review addresses recent studies mechanisms which communication molecules contribute development. Additionally, it explores potential therapeutic benefits TCM components treating from perspective osteoimmunology. The objective provide enhances immune‐related diseases facilitate development novel strategies.

Язык: Английский

Процитировано

0