Dexmedetomidine inhibits ferroptosis through the Akt/GSK3β/Nrf2 axis and alleviates adriamycin-induced cardiotoxicity
Life Sciences,
Год журнала:
2025,
Номер
371, С. 123609 - 123609
Опубликована: Апрель 5, 2025
Язык: Английский
A novel approach to the prevention and management of chemotherapy-induced cardiotoxicity: PANoptosis
Chemico-Biological Interactions,
Год журнала:
2025,
Номер
407, С. 111379 - 111379
Опубликована: Янв. 8, 2025
Язык: Английский
Targeting FDX1 by trilobatin to inhibit cuproptosis in doxorubicin‐induced cardiotoxicity
British Journal of Pharmacology,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 11, 2025
Abstract
Background
and
Purpose
Doxorubicin
(DOX),
an
anthracycline
chemotherapeutic
agent,
whose
use
is
limited
owing
to
its
dose‐dependent
cardiotoxicity.
Mitochondrial
oxidative
stress
plays
a
crucial
role
in
the
pathogenesis
of
DOX‐induced
cardiotoxicity
(DIC).
Trilobatin
(TLB),
naturally
occurring
food
additive,
exhibits
strong
antioxidant
properties,
but
cardioprotective
effects
DIC
unclear.
This
study
investigates
effect
TLB
on
DIC.
Experimental
Approach
DOX
was
used
generate
vivo
vitro
model
Echocardiography,
enzyme‐linked
immunosorbent
assay
(ELISA)
haematoxylin
eosin
(H&E)
staining
were
evaluate
cardiac
function
these
models.
To
identify
targets
TLB,
RNA‐sequence
analysis,
molecular
dynamics
simulations,
surface
plasmon
resonance
binding
assays
protein
immunoblotting
techniques
used.
Transmission
electron
microscopy,
along
with
dihydroethidium
Mito‐SOX
staining,
conducted
examine
impact
trilobatin
mitochondrial
stress.
SiRNA
transfection
performed
confirm
ferredoxin
1
(FDX1)
development.
Key
Results
In
mice,
improved
manner
inhibited
myocardial
fibrosis
mice.
also
attenuated
dysfunction
reduced
found
directly
bind
FDX1
suppresses
cuproptosis
after
treatment,
causing
significant
inhibition
cuproptosis‐related
proteins.
Conclusions
Implications
first
show
that
strongly
inhibits
by
reducing
controlling
DOX‐mediated
targeting
FDX1.
Therefore,
as
potential
phytochemical
candidate
for
ameliorating
Язык: Английский
Early detection of anthracycline-induced cardiotoxicity
Clinica Chimica Acta,
Год журнала:
2024,
Номер
565, С. 120000 - 120000
Опубликована: Окт. 12, 2024
Although
anthracyclines
are
important
anticancer
agents,
their
use
is
limited
due
to
various
adverse
effects,
particularly
cardiac
toxicity.
Mechanisms
underlying
anthracycline-induced
cardiotoxicity
(AIC)
complex.
Given
the
irreplaceable
role
of
in
treatment
malignancies
and
other
serious
diseases,
early
monitoring
AIC
paramount.
In
recent
years,
multiple
studies
have
investigated
biomarkers
for
detection
AIC.
Currently,
two
most
common
troponin
B-type
natriuretic
peptide.
addition,
a
range
molecules,
including
RNAs,
myeloperoxidase
(MPO),
C-reactive
protein
(CRP),
genes,
others,
also
play
roles
prediction.
Unfortunately,
current
research
indicates
need
validate
sensitivity
specificity
these
especially
large
study
populations.
this
review,
we
summarize
mechanisms
potential
AIC,
although
some
remain
preliminary.
Язык: Английский
Oxidative Stress and Inflammation in Myocardial Ischemia–Reperfusion Injury: Protective Effects of Plant‐Derived Natural Active Compounds
Journal of Applied Toxicology,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 31, 2024
ABSTRACT
Acute
myocardial
infarction
(AMI)
remains
a
leading
cause
of
death
among
patients
with
cardiovascular
diseases.
Percutaneous
coronary
intervention
(PCI)
has
been
the
preferred
clinical
treatment
for
AMI
due
to
its
safety
and
efficiency.
However,
research
indicates
that
rapid
restoration
oxygen
supply
following
PCI
can
lead
secondary
injury,
termed
ischemia–reperfusion
injury
(MIRI),
posing
grave
threat
patient
survival.
Despite
ongoing
efforts,
mechanisms
underlying
MIRI
are
not
yet
fully
elucidated.
Among
them,
oxidative
stress
inflammation
stand
out
as
critical
pathophysiological
mechanisms,
playing
significant
roles
in
MIRI.
Natural
compounds
have
shown
strong
therapeutic
potential
their
high
efficacy,
availability,
low
side
effects.
Many
current
studies
indicate
natural
mitigate
by
reducing
inflammatory
responses.
Therefore,
this
paper
reviews
during
role
intervening
these
processes,
aiming
provide
basis
reference
future
development
drugs
treating
Язык: Английский
New insights into mitochondrial quality control in anthracycline-induced cardiotoxicity: molecular mechanisms, therapeutic targets, and natural products
International Journal of Biological Sciences,
Год журнала:
2024,
Номер
21(2), С. 507 - 523
Опубликована: Дек. 31, 2024
Anthracyclines
(ANTs)
are
widely
used
in
cancer
therapy,
particularly
for
lymphoma,
sarcoma,
breast
cancer,
and
childhood
leukemia,
have
become
the
cornerstone
of
chemotherapy
various
malignancies.However,
it
is
associated
with
fatal
dose-dependent
cardiovascular
complications,
especially
cardiotoxicity.Mitochondrial
quality
control
mechanisms,
encompassing
mitophagy,
mitochondrial
dynamics,
biogenesis,
maintain
homeostasis
system.Recent
studies
highlighted
that
mechanisms
play
considerable
roles
ANTs-induced
cardiotoxicity
(AIC).In
addition,
natural
products
targeting
emerged
as
potential
therapeutic
strategies
to
alleviate
AIC.This
review
summarizes
types,
incidence,
prevention,
treatment,
pathomechanism
AIC,
delves
into
molecular
pathogenesis
explores
target
these
so
provide
targets
drugs
address
clinical
challenges
AIC
prevention
where
no
effective
medicines
available.
Язык: Английский