Resveratrol-driven macrophage polarization: unveiling mechanisms and therapeutic potential
Frontiers in Pharmacology,
Год журнала:
2025,
Номер
15
Опубликована: Янв. 13, 2025
Resveratrol,
a
polyphenolic
compound
known
for
its
diverse
biological
activities,
has
demonstrated
multiple
pharmacological
effects,
including
anti-inflammatory,
anti-aging,
anti-diabetic,
anti-cancer,
and
cardiovascular
protective
properties.
Recent
studies
suggest
that
these
effects
are
partly
mediated
through
the
regulation
of
macrophage
polarization,
wherein
macrophages
differentiate
into
pro-inflammatory
M1
or
anti-inflammatory
M2
phenotypes.
Our
review
highlights
how
resveratrol
modulates
polarization
various
signaling
pathways
to
achieve
therapeutic
effects.
For
example,
can
activate
senescence-associated
secretory
phenotype
(SASP)
pathway
inhibit
signal
transducer
activator
transcription
(STAT3)
sphingosine-1-phosphate
(S1P)-YAP
axes,
promoting
suppressing
thereby
inhibiting
tumor
growth.
Conversely,
it
promote
suppress
by
NF-κB
activating
PI3K/Akt
AMP-activated
protein
kinase
(AMPK)
pathways,
thus
alleviating
inflammatory
responses.
Notably,
effect
on
is
concentration-dependent;
moderate
concentrations
tend
while
higher
may
favor
polarization.
This
concentration
dependence
offers
new
perspectives
clinical
treatment
but
also
underscores
necessity
precise
dosage
control
when
using
resveratrol.
In
summary,
exhibits
significant
potential
in
regulating
treating
related
diseases.
Язык: Английский
The STING Signaling: A Novel Target for Central Nervous System Diseases
Cellular and Molecular Neurobiology,
Год журнала:
2025,
Номер
45(1)
Опубликована: Апрель 7, 2025
The
canonical
cyclic
GMP-AMP
(cGAMP)
synthase
(cGAS)-Stimulator
of
Interferon
Genes
(STING)
pathway
has
been
widely
recognized
as
a
crucial
mediator
inflammation
in
many
diseases,
including
tumors,
infections,
and
tissue
damage.
STING
signaling
can
also
be
activated
cGAS-
or
cGAMP-independent
manner,
although
the
specific
mechanisms
remain
unclear.
In-depth
studies
on
structural
molecular
biology
have
led
to
development
therapeutic
strategies
involving
modulators
their
targeted
delivery.
These
may
effectively
penetrate
blood-brain
barrier
(BBB)
target
multiple
central
nervous
system
(CNS)
diseases
humans.
In
this
review,
we
outline
both
non-canonical
pathways
activation
describe
general
associations
between
activity
CNS
diseases.
Finally,
discuss
prospects
for
delivery
clinical
application
agonists
inhibitors,
highlighting
novel
Язык: Английский
Novel Hsp90α inhibitor inhibits HSV-1 infection by suppressing the Akt/β-catenin pathway
Zexu Wang,
Weixiangmin Zou,
Qiongzhen Zeng
и другие.
International Journal of Antimicrobial Agents,
Год журнала:
2025,
Номер
65(3), С. 107448 - 107448
Опубликована: Янв. 23, 2025
Язык: Английский
Dihydro-R Demonstrates Innate Immunity Against Adenovirus-7 by Suppressing the NF-κB/JAK-STAT Pathway in a SIRT1-Dependent Manner
Опубликована: Янв. 1, 2025
Язык: Английский
An updated review of HSV-1 infection-associated diseases and treatment, vaccine development, and vector therapy application
Virulence,
Год журнала:
2024,
Номер
15(1)
Опубликована: Ноя. 7, 2024
Herpes
simplex
virus
type
1
(HSV-1)
is
a
globally
widespread
that
causes
and
associates
with
wide
range
of
diseases,
including
herpes
encephalitis,
keratitis,
labialis.
The
interaction
between
HSV-1
the
host
involves
complex
immune
response
mechanisms,
recognition
viral
invasion,
maintenance
latent
infection,
triggering
reactivation.
Antiviral
therapy
core
treatment
for
infections.
Meanwhile,
vaccine
development
employs
different
strategies
methods,
several
promising
types
have
emerged,
such
as
live
attenuated,
protein
subunit,
nucleic
acid
vaccines,
offering
new
possibilities
prevention
infection.
Moreover,
can
be
modified
into
therapeutic
vector
gene
tumour
immunotherapy.
This
review
provides
an
in-depth
summary
infection-associated
innate
adaptive
responses,
disease
pathogenesis,
current
approaches,
recent
advances
in
development,
applications
cancer
treatment.
Through
systematic
multiple
aspects
HSV-1,
this
study
aims
to
provide
comprehensive
detailed
reference
public
on
prevention,
control,
HSV-1.
Язык: Английский
Resveratrol’s Action against Viral Infections
Advances in Pharmacology & Clinical Trials,
Год журнала:
2024,
Номер
9(2), С. 1 - 3
Опубликована: Май 10, 2024
The
biological
activity
of
resveratrol
(3,5,4’-trihydroxy-trans-stilbene)
has
been
the
subject
extensive
study
in
treatment
various
diseases
due
to
its
anti-inflammatory,
antioxidant
and
anticancer
activities,
as
well
minimal
toxicity
side
effects.
It
widely
accepted
that
also
antiviral
activities.
In
this
mini-review,
we
summarize
resveratrol’s
mechanisms.
Since
viral
infections
are
often
accompanied
by
inflammation,
TLRs/NF-κB
signaling
pathways
key
common
molecular
mechanisms
for
exert
anti-inflammatory
Язык: Английский