Mechanisms underlying the involvement of peritoneal macrophages in the pathogenesis and novel therapeutic strategies for dialysis-induced peritoneal fibrosis DOI Creative Commons

Yangwei Wang,

Yixian Zhang,

Mingqi Ma

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 19, 2024

Long-term exposure of the peritoneum to peritoneal dialysate results in pathophysiological changes anatomical organization and progressive development fibrosis. This leads a decline function ultrafiltration failure, ultimately necessitating discontinuation dialysis, severely limiting potential for long-term maintenance. Additionally, encapsulating sclerosis, serious consequence fibrosis, resulting patients discontinuing PD significant mortality. The causes mechanisms underlying fibrosis undergoing dialysis remain unknown, with no definitive treatment available. However, abnormal activation immune system appears be involved altering structure promoting fibrotic changes. Macrophage infiltration polarization are key contributors pathological injury within peritoneum, showing strong correlation epithelial-to-mesenchymal transition mesothelial cells driving process article discusses role macrophage activation-induced from by analyzing relevant literature past decade provides an overview recent therapeutic approaches targeting macrophages treat this condition.

Language: Английский

Integrated UHPLC-Q-Exactive Orbitrap HRMS and Serum Pharmacochemistry for the Investigation of Anti-hepatic Fibrosis Effect of BaoGanNing Decoction DOI

Kaili Deng,

Min Li,

Liangliang Xiang

et al.

Phytomedicine, Journal Year: 2025, Volume and Issue: 137, P. 156363 - 156363

Published: Jan. 2, 2025

Language: Английский

Citations

1
Elucidation of Anti-Obesity Mechanisms of Phenolics in Artemisiae argyi Folium (Aiye) by Integrating LC-MS, Network Pharmacology, and Molecular Docking DOI Creative Commons
Yongxiang Liu, Jinhai Luo, Baojun Xu

et al.

Life, Journal Year: 2024, Volume and Issue: 14(6), P. 656 - 656

Published: May 22, 2024

The global prevalence of obesity is a pressing health issue, increasing the medical burden and posing significant risks to humans. side effects complications associated with conventional medication surgery have spurred search for anti-obesity drugs from plant resources. Previous studies suggested that Artemisiae argyi Folium (Aiye) water extracts could inhibit pancreatic lipase activities, control body weight increase, improve plasma lipids profile. However, exact components mechanisms were not precisely understood. Therefore, this research aims identify chemical profile Aiye provide comprehensive prediction its mechanisms. extract was subjected LC-MS analysis, which identified 30 phenolics. these phenolics then predicted, employing network pharmacology molecular docking. Among phenolics, 21 passed drug-likeness screening exhibited 486 targets. enrichment analysis revealed may combat through PI3K-Akt signaling MAPK, prolactin, cAMP pathways. Eight seven central targets selected docking, 45 out 56 docking had binding affinity less than −5 kcal/mol. This has indicated potential therapy pathways in combating obesity.

Language: Английский

Citations

4
HMGB1: key mediator in digestive system diseases DOI

Heng-Qian Liu,

Xiping Liao, Zhang Zuo

et al.

Inflammation Research, Journal Year: 2025, Volume and Issue: 74(1)

Published: Feb. 4, 2025

Language: Английский

Citations

0
Jaceosidin overcomes osimertinib resistance in lung cancer by inducing G2/M cycle arrest through targeting DDB1 DOI Creative Commons

Zhijie Chen,

Zhuoying Yang, Yingying Liu

et al.

Toxicology and Applied Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 117327 - 117327

Published: April 1, 2025

Language: Английский

Citations

0
Natural Compounds in Cancer Therapy: Revealing the Role of Flavonoids in Renal Cell Carcinoma Treatment DOI Creative Commons
Zixuan Chen, Min Liu

Biomolecules, Journal Year: 2025, Volume and Issue: 15(5), P. 620 - 620

Published: April 25, 2025

Renal cell carcinoma (RCC) is the most lethal malignancy of urinary system, with limited treatment options due to drug resistance and adverse effects associated current therapies. This review aims systematically examine therapeutic potential flavonoids, which are natural polyphenolic compounds possessing anti-inflammatory, antioxidant, anticancer properties, in context RCC treatment. We summarize activities 26 classified into six subclasses, explore their mechanisms action, including inhibition tumor proliferation, migration, invasion, as well induction apoptosis, autophagy, ferroptosis. Particular attention paid modulation key signaling pathways such JAK/STAT3, PI3K/Akt/mTOR, miRNA-related axes, miR-21/YAP1 miR-324-3p/GPX4, providing a molecular basis for anti-RCC activity. also address several pharmacological challenges that limit clinical application poor bioavailability, metabolic instability, toxicity. Emerging solutions novel flavonoid derivatives, advanced delivery systems, rational combination therapy strategies discussed. Current evidence, phase II trial flavopiridol RCC, highlights but need further validation. In conclusion, flavonoids offer promising approach improving Future research should focus on optimizing efficacy ensuring safe translation, goal achieving personalized minimally invasive cancer

Language: Английский

Citations

0
Mechanisms underlying the involvement of peritoneal macrophages in the pathogenesis and novel therapeutic strategies for dialysis-induced peritoneal fibrosis DOI Creative Commons

Yangwei Wang,

Yixian Zhang,

Mingqi Ma

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 19, 2024

Long-term exposure of the peritoneum to peritoneal dialysate results in pathophysiological changes anatomical organization and progressive development fibrosis. This leads a decline function ultrafiltration failure, ultimately necessitating discontinuation dialysis, severely limiting potential for long-term maintenance. Additionally, encapsulating sclerosis, serious consequence fibrosis, resulting patients discontinuing PD significant mortality. The causes mechanisms underlying fibrosis undergoing dialysis remain unknown, with no definitive treatment available. However, abnormal activation immune system appears be involved altering structure promoting fibrotic changes. Macrophage infiltration polarization are key contributors pathological injury within peritoneum, showing strong correlation epithelial-to-mesenchymal transition mesothelial cells driving process article discusses role macrophage activation-induced from by analyzing relevant literature past decade provides an overview recent therapeutic approaches targeting macrophages treat this condition.

Language: Английский

Citations

1