Psyllium Husk Powder improves constipation by remodeling gut microbiota and improving intestinal metabolites
Food Bioscience,
Год журнала:
2025,
Номер
unknown, С. 105828 - 105828
Опубликована: Янв. 1, 2025
Язык: Английский
Resveratrol alleviates testicular toxicity induced by anti-PD-1 through regulating the NRF2-SLC7A11-GPX4 pathway
Frontiers in Immunology,
Год журнала:
2025,
Номер
16
Опубликована: Март 12, 2025
Background
Fertility
preservation
is
a
critical
concern
for
reproductive-age
cancer
survivors,
as
conventional
cytotoxic
therapies
can
cause
irreversible
damage
to
the
reproductive
system,
potentially
depriving
them
of
ability
have
children
in
future.
Immune
checkpoint
inhibitors
(ICIs),
including
anti-programmed
cell
death
protein
1
(anti-PD-1),
become
standard
therapeutic
approach
various
malignancies.
However,
impact
ICIs
on
function
and
fertility
not
well
understood
remains
largely
unexplored
domain.
Resveratrol
(RSV),
plant-derived
compound,
has
shown
potential
an
nuclear
factor
erythroid
2-related
2
(NRF2)
agonist
counteract
toxicity
induced
by
diseases,
drugs,
environmental
toxins.
Methods
Male
C57BL6/J
mice
with
B16
melanoma
were
assigned
into
four
groups.
RSV
ICI/RSV
groups
received
(40
mg/kg)
orally
every
other
day
one
month,
while
controls
vehicle.
ICI
injected
anti-PD-1
antibody
(10
weekly,
IgG2b
kappa
antibody.
Parameters
like
body
testicular
weight,
sperm
concentration,
western
blot
ferroptosis
markers
measured.
Furthermore,
oxidative
stress
biomarkers,
lipid
oxidation
factors,
gonadal
hormone
levels
quantified
using
commercial
kits.
Results
Anti-PD-1
therapy
caused
male
dysfunction,
evidenced
reduced
altered
levels,
disruption
blood-testis
barrier
(BTB)
integrity.
was
key
mechanism
anti-PD-1-induced
characterized
disrupted
iron
homeostasis,
elevated
peroxidation,
suppression
system
Xc−/glutathione
peroxidase
4
(GPX4)
axis.
Additionally,
diminished
antioxidant
defenses
inhibiting
NRF2
pathway,
thereby
increasing
susceptibility
ferroptosis.
Crucially,
treatment
ameliorated
dysfunction.
This
achieved
reducing
T
infiltration,
lowering
interferon-gamma
activating
maintaining
homeostasis.
Conclusions
Our
study
demonstrates
that
triggers
testis,
causing
may
offer
protection
against
associated
anti-PD-1,
particularly
through
its
anti-ferroptosis
properties.
Язык: Английский
Iberverin Downregulates GPX4 and SLC7A11 to Induce Ferroptotic Cell Death in Hepatocellular Carcinoma Cells
Biomolecules,
Год журнала:
2024,
Номер
14(11), С. 1407 - 1407
Опубликована: Ноя. 5, 2024
Ferroptosis,
a
recently
elucidated
style
of
regulated
cell
death,
has
emerged
as
significant
area
investigation
in
cancer
biology.
Natural
active
compounds
that
have
anti-cancer
effects
are
promising
candidates
for
prevention.
Iberverin,
natural
compound
derived
from
Язык: Английский
Dynamic characterization of vascular response and treatment in oral traumatic ulcer in mice via photoacoustic imaging
Quantitative Imaging in Medicine and Surgery,
Год журнала:
2024,
Номер
14(7), С. 4333 - 4347
Опубликована: Июнь 11, 2024
Dynamic
surveillance
of
vasculature
is
essential
for
evaluating
the
healing
oral
ulcer.
Existing
techniques
used
in
vascular
imaging
face
limitations,
such
as
inadequate
spatial
resolution,
restricted
diagnostic
depth,
and
necessity
exogenous
contrast
agents.
Therefore,
this
study
aimed
to
use
robust
photoacoustic
(PAI)
dynamic
monitoring
response
during
associated
treatment
process
Язык: Английский
Cucurbitacin B and Its Derivatives: A Review of Progress in Biological Activities
Molecules,
Год журнала:
2024,
Номер
29(17), С. 4193 - 4193
Опубликована: Сен. 4, 2024
The
emergence
of
natural
products
has
provided
extremely
valuable
references
for
the
treatment
various
diseases.
Cucurbitacin
B,
a
tetracyclic
triterpenoid
compound
isolated
from
cucurbitaceae
and
other
plants,
is
most
abundant
member
cucurbitin
family
exhibits
wide
range
biological
activities,
including
anti-inflammatory,
anti-cancer,
even
agricultural
applications.
Due
to
its
high
toxicity
narrow
therapeutic
window,
structural
modification
dosage
form
development
are
necessary
address
these
issues
with
cucurbitacin
B.
This
paper
reviews
recent
research
progress
in
pharmacological
action,
modification,
application
review
aims
enhance
understanding
advancements
this
field
provide
constructive
suggestions
further
on
Язык: Английский
Resveratrol alleviates testicular toxicity induced by anti-PD-1 through regulating the NRF2-SLC7A11-GPX4 pathway
Research Square (Research Square),
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 4, 2024
Abstract
Background:
Fertility
preservation
is
a
critical
concern
for
reproductive-age
cancer
survivors,
as
conventional
cytotoxic
therapies
can
cause
irreversible
damage
to
the
reproductive
system,
potentially
depriving
them
of
ability
have
children
in
future.
Immune
checkpoint
inhibitors
(ICIs),
including
anti-programmed
cell
death
protein
1
(anti-PD-1),
become
standard
therapeutic
approach
various
malignancies.
However,
impact
ICIs
on
function
and
fertility
not
well
understood
remains
largely
unexplored
domain.
Methods:
Male
C57BL6/J
mice
with
B16
melanoma
were
assigned
into
four
groups:
control
,
anti-PD-1
(ICI)
RSV,
RSV
(ICI/RSV)
group.
ICI/RSV
groups
received
(40
mg/kg)
orally
every
other
day
one
month,
while
controls
vehicle.
ICI
injected
antibody
(10
weekly,
IgG2b
kappa
antibody.
Parameters
like
body
testicular
weight,
sperm
concentration,
Western
blotting
ferroptosis
markers
measured.
Furthermore,
oxidative
stress
biomarkers,
lipid
oxidation
factors,
gonadal
hormone
levels
quantified
using
commercial
kits.
Results:
Anti-PD-1
therapy
caused
male
dysfunction,
evidenced
by
reduced
altered
levels,
disruption
blood-testis
barrier
(BTB)
integrity.
was
key
mechanism
anti-PD-1-induced
characterized
disrupted
iron
homeostasis,
elevated
peroxidation,
suppression
system
Xc−/glutathione
peroxidase
4
(GPX4)
axis.
Additionally,
therapy
diminished
antioxidant
defenses
inhibiting
nuclear
factor
erythroid
2-related
2
(NRF2)
pathway,
thereby
increasing
susceptibility
ferroptosis.
Crucially,
treatment
ameliorated
dysfunction.
This
achieved
reducing
T
infiltration,
lowering
interferon-gamma
activating
NRF2
maintainingiron
homeostasis.
Conclusions:
Our
study
demonstrates
that
anti-PD-1triggers
testis,
causing
Resveratrol
may
offer
protection
against
toxicity
associated
anti-PD-1,
particularly
through
its
anti-ferroptosis
properties.
Язык: Английский
WITHDRAWN: Resveratrol alleviates testicular toxicity induced by anti-PD-1 through regulating the NRF2-SLC7A11-GPX4 pathway
Research Square (Research Square),
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 6, 2024
Abstract
The
full
text
of
this
preprint
has
been
withdrawn
by
the
authors
while
they
make
corrections
to
work.
Therefore,
do
not
wish
work
be
cited
as
a
reference.
Questions
should
directed
corresponding
author.
Язык: Английский