WITHDRAWN: Resveratrol alleviates testicular toxicity induced by anti-PD-1 through regulating the NRF2-SLC7A11-GPX4 pathway DOI Creative Commons
Halahati Tuerxun, Yixin Zhao, Yawen Li

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 6, 2024

Abstract The full text of this preprint has been withdrawn by the authors while they make corrections to work. Therefore, do not wish work be cited as a reference. Questions should directed corresponding author.

Language: Английский

Psyllium Husk Powder improves constipation by remodeling gut microbiota and improving intestinal metabolites DOI

Zhengyu Wang,

Qianwen Lv,

Liangzhong Liu

et al.

Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 105828 - 105828

Published: Jan. 1, 2025

Language: Английский

Citations

0
Resveratrol alleviates testicular toxicity induced by anti-PD-1 through regulating the NRF2-SLC7A11-GPX4 pathway DOI Creative Commons
Halahati Tuerxun, Yixin Zhao, Yawen Li

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: March 12, 2025

Background Fertility preservation is a critical concern for reproductive-age cancer survivors, as conventional cytotoxic therapies can cause irreversible damage to the reproductive system, potentially depriving them of ability have children in future. Immune checkpoint inhibitors (ICIs), including anti-programmed cell death protein 1 (anti-PD-1), become standard therapeutic approach various malignancies. However, impact ICIs on function and fertility not well understood remains largely unexplored domain. Resveratrol (RSV), plant-derived compound, has shown potential an nuclear factor erythroid 2-related 2 (NRF2) agonist counteract toxicity induced by diseases, drugs, environmental toxins. Methods Male C57BL6/J mice with B16 melanoma were assigned into four groups. RSV ICI/RSV groups received (40 mg/kg) orally every other day one month, while controls vehicle. ICI injected anti-PD-1 antibody (10 weekly, IgG2b kappa antibody. Parameters like body testicular weight, sperm concentration, western blot ferroptosis markers measured. Furthermore, oxidative stress biomarkers, lipid oxidation factors, gonadal hormone levels quantified using commercial kits. Results Anti-PD-1 therapy caused male dysfunction, evidenced reduced altered levels, disruption blood-testis barrier (BTB) integrity. was key mechanism anti-PD-1-induced characterized disrupted iron homeostasis, elevated peroxidation, suppression system Xc−/glutathione peroxidase 4 (GPX4) axis. Additionally, diminished antioxidant defenses inhibiting NRF2 pathway, thereby increasing susceptibility ferroptosis. Crucially, treatment ameliorated dysfunction. This achieved reducing T infiltration, lowering interferon-gamma activating maintaining homeostasis. Conclusions Our study demonstrates that triggers testis, causing may offer protection against associated anti-PD-1, particularly through its anti-ferroptosis properties.

Language: Английский

Citations

0
Iberverin Downregulates GPX4 and SLC7A11 to Induce Ferroptotic Cell Death in Hepatocellular Carcinoma Cells DOI Creative Commons

Haoying Yang,

Bolei Dai, Liangjie Chen

et al.

Biomolecules, Journal Year: 2024, Volume and Issue: 14(11), P. 1407 - 1407

Published: Nov. 5, 2024

Ferroptosis, a recently elucidated style of regulated cell death, has emerged as significant area investigation in cancer biology. Natural active compounds that have anti-cancer effects are promising candidates for prevention. Iberverin, natural compound derived from

Language: Английский

Citations

2
Dynamic characterization of vascular response and treatment in oral traumatic ulcer in mice via photoacoustic imaging DOI Open Access

Xiaoyu Miao,

Rui Ma,

Jiayi Li

et al.

Quantitative Imaging in Medicine and Surgery, Journal Year: 2024, Volume and Issue: 14(7), P. 4333 - 4347

Published: June 11, 2024

Dynamic surveillance of vasculature is essential for evaluating the healing oral ulcer. Existing techniques used in vascular imaging face limitations, such as inadequate spatial resolution, restricted diagnostic depth, and necessity exogenous contrast agents. Therefore, this study aimed to use robust photoacoustic (PAI) dynamic monitoring response during associated treatment process

Language: Английский

Citations

1
Cucurbitacin B and Its Derivatives: A Review of Progress in Biological Activities DOI Creative Commons

Wen-Zhe Nie,

Yalan Wang,

Xinlu Tian

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(17), P. 4193 - 4193

Published: Sept. 4, 2024

The emergence of natural products has provided extremely valuable references for the treatment various diseases. Cucurbitacin B, a tetracyclic triterpenoid compound isolated from cucurbitaceae and other plants, is most abundant member cucurbitin family exhibits wide range biological activities, including anti-inflammatory, anti-cancer, even agricultural applications. Due to its high toxicity narrow therapeutic window, structural modification dosage form development are necessary address these issues with cucurbitacin B. This paper reviews recent research progress in pharmacological action, modification, application review aims enhance understanding advancements this field provide constructive suggestions further on

Language: Английский

Citations

1
Resveratrol alleviates testicular toxicity induced by anti-PD-1 through regulating the NRF2-SLC7A11-GPX4 pathway DOI Creative Commons
Halahati Tuerxun, Yixin Zhao, Yawen Li

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 4, 2024

Abstract Background: Fertility preservation is a critical concern for reproductive-age cancer survivors, as conventional cytotoxic therapies can cause irreversible damage to the reproductive system, potentially depriving them of ability have children in future. Immune checkpoint inhibitors (ICIs), including anti-programmed cell death protein 1 (anti-PD-1), become standard therapeutic approach various malignancies. However, impact ICIs on function and fertility not well understood remains largely unexplored domain. Methods: Male C57BL6/J mice with B16 melanoma were assigned into four groups: control , anti-PD-1 (ICI) RSV, RSV (ICI/RSV) group. ICI/RSV groups received (40 mg/kg) orally every other day one month, while controls vehicle. ICI injected antibody (10 weekly, IgG2b kappa antibody. Parameters like body testicular weight, sperm concentration, Western blotting ferroptosis markers measured. Furthermore, oxidative stress biomarkers, lipid oxidation factors, gonadal hormone levels quantified using commercial kits. Results: Anti-PD-1 therapy caused male dysfunction, evidenced by reduced altered levels, disruption blood-testis barrier (BTB) integrity. was key mechanism anti-PD-1-induced characterized disrupted iron homeostasis, elevated peroxidation, suppression system Xc−/glutathione peroxidase 4 (GPX4) axis. Additionally, therapy diminished antioxidant defenses inhibiting nuclear factor erythroid 2-related 2 (NRF2) pathway, thereby increasing susceptibility ferroptosis. Crucially, treatment ameliorated dysfunction. This achieved reducing T infiltration, lowering interferon-gamma activating NRF2 maintainingiron homeostasis. Conclusions: Our study demonstrates that anti-PD-1triggers testis, causing Resveratrol may offer protection against toxicity associated anti-PD-1, particularly through its anti-ferroptosis properties.

Language: Английский

Citations

0
WITHDRAWN: Resveratrol alleviates testicular toxicity induced by anti-PD-1 through regulating the NRF2-SLC7A11-GPX4 pathway DOI Creative Commons
Halahati Tuerxun, Yixin Zhao, Yawen Li

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 6, 2024

Abstract The full text of this preprint has been withdrawn by the authors while they make corrections to work. Therefore, do not wish work be cited as a reference. Questions should directed corresponding author.

Language: Английский

Citations

0