Phytomedicine, Год журнала: 2024, Номер 135, С. 156211 - 156211
Опубликована: Ноя. 10, 2024
Язык: Английский
Phytomedicine, Год журнала: 2024, Номер 135, С. 156211 - 156211
Опубликована: Ноя. 10, 2024
Язык: Английский
Molecular Neurobiology, Год журнала: 2025, Номер unknown
Опубликована: Март 4, 2025
Язык: Английский
Процитировано
0ACS Nano, Год журнала: 2025, Номер unknown
Опубликована: Март 6, 2025
Neuroinflammation is a critical factor in the progression of cerebral ischemia-reperfusion injury (CIRI). Pyroptosis, which an inflammatory form programmed cell death, greatly amplifies neuroinflammatory processes. It does so by promoting release various contents that intensify overall response within central nervous system. Therefore, targeting pyroptosis represents promising therapeutic strategy for treatment CIRI. Excessive generation reactive oxygen species (ROS) overactivated microglia considered to serve as signal molecule triggers NLRP3 inflammasome-mediated pyroptosis. However, current inhibitors solely focus on eliminating existing ROS or inhibiting inflammasome are not optimal. Here, coating nanothylakoids (NTs) coengineered with fibrin-binding peptide and MG1 onto dihydrotanshinone I (DT)-loaded nanocarriers, we have developed cascade-type inhibitor (MDN-MC) comprehensively regulates ROS/NLRP3/pyroptosis axis. The incorporation catalase surface MDN-MC, along DT, facilitated cascade inhibition scavenging suppressing expression NLRP3. In rat model transient middle artery occlusion, enhanced behavioral recovery neuronal repair were achieved through at lesion site implementation interventions inhibit pyroptosis, thereby demonstrating effects. Overall, this work emphasizes importance cascade-regulated reducing neuroinflammation, offering important mechanistic understanding possible approaches
Язык: Английский
Процитировано
0Journal of Chromatography B, Год журнала: 2025, Номер 1262, С. 124669 - 124669
Опубликована: Май 20, 2025
Язык: Английский
Процитировано
0Frontiers in Pharmacology, Год журнала: 2025, Номер 16
Опубликована: Май 29, 2025
Ferroptosis is a new type of controlled cell death. It distinguished by its reliance on iron and the production lipid peroxidation. The role ferroptosis in stroke has attracted lot attention recently. purpose this review to clarify connection between investigate potential contribution natural products clinical management discovery novel medications. In review, we summarize detail mechanism after stroke, especially relevant targets stroke. Furthermore, herbal medicine currently employed along with their mechanisms action, highlighting challenges translation. We included 55 articles classified them. After systematic screening, think that ginkgolide B, kellerin, loureirin C, quercetin, icariside II, salvianolic acid A, berberine, Dl-3-n-butylphthalide an effective candidate drug for treatment
Язык: Английский
Процитировано
0Phytomedicine, Год журнала: 2024, Номер 135, С. 156211 - 156211
Опубликована: Ноя. 10, 2024
Язык: Английский
Процитировано
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