CDC42 Regulates the ERK Pathway to Improve Oxygen‒Glucose Deprivation/Reoxygenation-Induced Neural Oxidative Stress and Apoptosis

Molecular Neurobiology, Journal Year: 2025, Volume and Issue: unknown

Published: March 4, 2025

Language: Английский

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Cascade-Type Microglial Pyroptosis Inhibitors for Enhanced Treatment of Cerebral Ischemia-Reperfusion Injury

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: March 6, 2025

Neuroinflammation is a critical factor in the progression of cerebral ischemia-reperfusion injury (CIRI). Pyroptosis, which an inflammatory form programmed cell death, greatly amplifies neuroinflammatory processes. It does so by promoting release various contents that intensify overall response within central nervous system. Therefore, targeting pyroptosis represents promising therapeutic strategy for treatment CIRI. Excessive generation reactive oxygen species (ROS) overactivated microglia considered to serve as signal molecule triggers NLRP3 inflammasome-mediated pyroptosis. However, current inhibitors solely focus on eliminating existing ROS or inhibiting inflammasome are not optimal. Here, coating nanothylakoids (NTs) coengineered with fibrin-binding peptide and MG1 onto dihydrotanshinone I (DT)-loaded nanocarriers, we have developed cascade-type inhibitor (MDN-MC) comprehensively regulates ROS/NLRP3/pyroptosis axis. The incorporation catalase surface MDN-MC, along DT, facilitated cascade inhibition scavenging suppressing expression NLRP3. In rat model transient middle artery occlusion, enhanced behavioral recovery neuronal repair were achieved through at lesion site implementation interventions inhibit pyroptosis, thereby demonstrating effects. Overall, this work emphasizes importance cascade-regulated reducing neuroinflammation, offering important mechanistic understanding possible approaches

Language: Английский

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Chemical identification and metabolic profiling of Tongmai granules using modified mass defect filtering techniques and its network pharmacology study

Journal of Chromatography B, Journal Year: 2025, Volume and Issue: 1262, P. 124669 - 124669

Published: May 20, 2025

Language: Английский

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Targeting ferroptosis with natural products in stroke: therapeutic mechanisms and translational opportunities

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: May 29, 2025

Ferroptosis is a new type of controlled cell death. It distinguished by its reliance on iron and the production lipid peroxidation. The role ferroptosis in stroke has attracted lot attention recently. purpose this review to clarify connection between investigate potential contribution natural products clinical management discovery novel medications. In review, we summarize detail mechanism after stroke, especially relevant targets stroke. Furthermore, herbal medicine currently employed along with their mechanisms action, highlighting challenges translation. We included 55 articles classified them. After systematic screening, think that ginkgolide B, kellerin, loureirin C, quercetin, icariside II, salvianolic acid A, berberine, Dl-3-n-butylphthalide an effective candidate drug for treatment

Language: Английский

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Exploration the effective components of Gastrodia elata in improving cerebral ischemia reperfusion injury based on “Spectrum-effect” correlation and zebrafish verification experiment

Phytomedicine, Journal Year: 2024, Volume and Issue: 135, P. 156211 - 156211

Published: Nov. 10, 2024

Language: Английский

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