Alkaloids with Their Protective Effects Against Aβ25-35-Induced PC-12 Cell Injury from the Tubers of Pinellia pedatisecta Schott DOI Creative Commons
Xu Chen, Yan-Gang Cao,

Kaili Ye

и другие.

Molecules, Год журнала: 2024, Номер 29(21), С. 5059 - 5059

Опубликована: Окт. 26, 2024

Seven new alkaloids [1, (±)-2, (±)-3, 4, and 5] one natural product (6), along with eight known analogues, were isolated from the tubers of Pinellia pedatisecta Schott. Their structures determined by a comprehensive analysis spectroscopic data, including HRESIMS, electronic circular dichroism (ECD). In addition, results bioactivity evaluation showed that compounds 6, 9 exhibited significantly protective effects against Aβ25-35-induced PC-12 cell injury ameliorated viabilities decreasing levels reactive oxidative species (ROS) mitochondrial membrane potential (MMP).

Язык: Английский

Aqueous Extract of Cornus officinalis Alleviate NAFLD via Protecting Hepatocytes Proliferation through Regulation of the Tricarboxylic Acid Cycle DOI

Binjie Liu,

Ting Shao, Dandan Xiao

и другие.

Journal of Ethnopharmacology, Год журнала: 2025, Номер 341, С. 119330 - 119330

Опубликована: Янв. 6, 2025

Язык: Английский

Процитировано

0

Neuroprotective triterpenoids from Astragalus membranaceus stems and leaves: Anti-inflammatory and anti-apoptotic mechanisms for memory improvement via in vivo and in vitro models DOI
Yan‐Gang Cheng, Jianli Li, Pei Li

и другие.

Bioorganic Chemistry, Год журнала: 2025, Номер unknown, С. 108492 - 108492

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0

Investigating the possible mechanism of Cornus officinalis in the therapy of ischemic stroke by UHPLC-Q-TOF-MS, network pharmacology, molecular docking, and experimental verification DOI
Yan Zhang, Peipei Yuan,

Pan-Ying Li

и другие.

Journal of Ethnopharmacology, Год журнала: 2024, Номер 338, С. 119072 - 119072

Опубликована: Ноя. 8, 2024

Язык: Английский

Процитировано

1

Alkaloids with Their Protective Effects Against Aβ25-35-Induced PC-12 Cell Injury from the Tubers of Pinellia pedatisecta Schott DOI Creative Commons
Xu Chen, Yan-Gang Cao,

Kaili Ye

и другие.

Molecules, Год журнала: 2024, Номер 29(21), С. 5059 - 5059

Опубликована: Окт. 26, 2024

Seven new alkaloids [1, (±)-2, (±)-3, 4, and 5] one natural product (6), along with eight known analogues, were isolated from the tubers of Pinellia pedatisecta Schott. Their structures determined by a comprehensive analysis spectroscopic data, including HRESIMS, electronic circular dichroism (ECD). In addition, results bioactivity evaluation showed that compounds 6, 9 exhibited significantly protective effects against Aβ25-35-induced PC-12 cell injury ameliorated viabilities decreasing levels reactive oxidative species (ROS) mitochondrial membrane potential (MMP).

Язык: Английский

Процитировано

0