Alkaloids with Their Protective Effects Against Aβ25-35-Induced PC-12 Cell Injury from the Tubers of Pinellia pedatisecta Schott DOI Creative Commons
Xu Chen, Yan-Gang Cao,

Kaili Ye

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(21), P. 5059 - 5059

Published: Oct. 26, 2024

Seven new alkaloids [1, (±)-2, (±)-3, 4, and 5] one natural product (6), along with eight known analogues, were isolated from the tubers of Pinellia pedatisecta Schott. Their structures determined by a comprehensive analysis spectroscopic data, including HRESIMS, electronic circular dichroism (ECD). In addition, results bioactivity evaluation showed that compounds 6, 9 exhibited significantly protective effects against Aβ25-35-induced PC-12 cell injury ameliorated viabilities decreasing levels reactive oxidative species (ROS) mitochondrial membrane potential (MMP).

Language: Английский

Aqueous Extract of Cornus officinalis Alleviate NAFLD via Protecting Hepatocytes Proliferation through Regulation of the Tricarboxylic Acid Cycle DOI

Binjie Liu,

Ting Shao, Dandan Xiao

et al.

Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: 341, P. 119330 - 119330

Published: Jan. 6, 2025

Language: Английский

Citations

0
Neuroprotective triterpenoids from Astragalus membranaceus stems and leaves: Anti-inflammatory and anti-apoptotic mechanisms for memory improvement via in vivo and in vitro models DOI
Yan‐Gang Cheng, Jianli Li, Pei Li

et al.

Bioorganic Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 108492 - 108492

Published: April 1, 2025

Language: Английский

Citations

0
Investigating the possible mechanism of Cornus officinalis in the therapy of ischemic stroke by UHPLC-Q-TOF-MS, network pharmacology, molecular docking, and experimental verification DOI
Yan Zhang, Peipei Yuan,

Pan-Ying Li

et al.

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 338, P. 119072 - 119072

Published: Nov. 8, 2024

Language: Английский

Citations

1
Alkaloids with Their Protective Effects Against Aβ25-35-Induced PC-12 Cell Injury from the Tubers of Pinellia pedatisecta Schott DOI Creative Commons
Xu Chen, Yan-Gang Cao,

Kaili Ye

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(21), P. 5059 - 5059

Published: Oct. 26, 2024

Seven new alkaloids [1, (±)-2, (±)-3, 4, and 5] one natural product (6), along with eight known analogues, were isolated from the tubers of Pinellia pedatisecta Schott. Their structures determined by a comprehensive analysis spectroscopic data, including HRESIMS, electronic circular dichroism (ECD). In addition, results bioactivity evaluation showed that compounds 6, 9 exhibited significantly protective effects against Aβ25-35-induced PC-12 cell injury ameliorated viabilities decreasing levels reactive oxidative species (ROS) mitochondrial membrane potential (MMP).

Language: Английский

Citations

0