Plant-derived extracellular vesicles: a synergetic combination of a drug delivery system and a source of natural bioactive compounds
Drug Delivery and Translational Research,
Год журнала:
2024,
Номер
unknown
Опубликована: Авг. 28, 2024
Abstract
Exosomes
are
extracellular
nanovesicles
secreted
by
all
cell
types
and
have
been
studied
to
understand
treat
many
human
diseases.
involved
in
numerous
physiological
pathological
processes,
intercellular
communication,
the
transfer
of
substances.
Over
years,
several
studies
explored
mammalian-derived
exosomes
for
therapeutic
diagnostic
uses.
Only
recently
plant-derived
vesicles
(EVs)
attracted
attention
their
ability
overcome
defects
associated
with
using
vesicles,
such
as
safety
scale-up
issues.
The
ease
large-scale
production,
low
toxicity,
immunogenicity,
efficient
cellular
uptake,
high
biocompatibility,
stability
these
make
them
attractive
drug
delivery
systems.
In
addition,
native
contents
proteins,
miRNAs
secondary
metabolites
could
be
exploited
pharmaceutical
applications
combination
other
drugs.
present
review
intends
provide
adequate
tools
studying
developing
systems
based
on
EVs.
Therefore,
indications
concerning
extraction
methods,
characterisation,
loading
will
offered.
Their
biological
composition
content
also
reported.
Finally,
current
nanocarriers
pharmacologically
active
substances
shown.
Graphical
Язык: Английский
Flos Puerariae-derived exosomes-like nanoparticles ameliorate alcoholic liver disease by targeting IL-11-related signaling pathways and reactive oxygen species
Chemical Engineering Journal,
Год журнала:
2025,
Номер
unknown, С. 161896 - 161896
Опубликована: Март 1, 2025
Язык: Английский
Plant-Derived Extracellular Vesicles: Natural Nanocarriers for Biotechnological Drugs
Processes,
Год журнала:
2024,
Номер
12(12), С. 2938 - 2938
Опубликована: Дек. 23, 2024
Plant-derived
extracellular
vesicles
(PDEVs)
are
lipid
bilayer
nanoparticles,
naturally
produced
by
plant
cells,
with
sizes
ranging
from
50
to
500
nm.
Recent
studies
have
highlighted
their
great
potential
in
the
biotechnological
and
medical
fields,
due
natural
origin,
high
biocompatibility
intrinsic
therapeutic
properties.
PDEVs
contain
a
complex
biological
cargo
of
proteins,
lipids,
nucleic
acids
secondary
metabolites,
including
antioxidants
anti-inflammatory
molecules,
making
them
ideal
for
biomedical
applications
such
as
drug
delivery.
These
play
key
role
intercellular
communication
gene
regulation,
proving
be
particularly
promising
personalized
medicine.
ability
improve
stability
bioavailability,
optimizing
targeted
release
minimizing
side
effects.
Despite
some
challenges,
compositional
variability
need
standardized
protocols,
at
gunsight
innovative
research
aimed
improving
loading
capacity
specificity.
This
review
aims
provide
comprehensive
overview
PDEVs,
exploring
structure,
isolation
methods,
functional
characteristics,
applications,
highlighting
advantages
over
synthetic
nanoparticles
animal-derived
vesicles,
leading
an
sustainable
solution
development
new
approaches.
Язык: Английский
Aloe Extracellular Vesicles as Carriers of Photoinducible Metabolites Exhibiting Cellular Phototoxicity
Cells,
Год журнала:
2024,
Номер
13(22), С. 1845 - 1845
Опубликована: Ноя. 7, 2024
The
growing
interest
in
plant-origin
active
molecules
with
medicinal
properties
has
led
to
a
revaluation
of
plants
the
pharmaceutical
field.
Plant-derived
extracellular
vesicles
(PDEVs)
have
emerged
as
promising
candidates
for
next-generation
drug
delivery
systems
due
their
ability
concentrate
and
deliver
plethora
bioactive
molecules.
These
bilayer
membranous
vesicles,
whose
diameter
ranges
from
30
1000
nm,
are
released
by
different
cell
types
play
crucial
role
cross-kingdom
communication
between
humans.
Notably,
PDEVs
demonstrated
efficacy
treating
various
diseases,
including
cancer,
alcoholic
liver
disease,
inflammatory
bowel
disease.
However,
further
research
on
plant
is
necessary
fully
understand
traits
purposes.
This
study
investigates
phototoxic
effects
(EVs)
Язык: Английский
Bioinspired micro‐ and nanostructured systems for cancer therapy
MedComm,
Год журнала:
2024,
Номер
5(12)
Опубликована: Ноя. 28, 2024
Abstract
Numerous
organisms
in
nature
have
demonstrated
enhanced
biocompatibility,
precise
tumor
targeting
capabilities,
and
efficient
tissue
traversal
within
the
human
body.
Drawing
inspiration
from
these
organisms,
researchers
employed
bioengineering,
bioconjugation,
micro‐
or
nanotechnology
to
fabricate
bioinspired
nanostructured
systems.
These
systems
play
a
crucial
role
addressing
limitations
of
conventional
anticancer
drugs
nanomaterials
concerning
effective
penetration
physiological
barriers,
as
well
selective
targeting,
thereby
leading
improved
therapeutic
efficacy
while
minimizing
nonspecific
adverse
effects
on
healthy
cells.
Consequently,
extensive
exploration
has
been
undertaken
across
various
cancer
treatment
modalities
with
some
progressing
into
preclinical
clinical
stages.
However,
our
understanding
this
field
remains
limited
which
may
impede
research
progress,
translation
efforts,
practical
applications.
Therefore,
study
presents
systematic
classification
for
therapy
that
comprehensively
elucidates
their
sources
design
principles.
Furthermore,
it
extensively
discusses
current
status
efforts
identifying
prevailing
challenges
exploring
future
prospects.
This
work
will
establish
robust
theoretical
framework
serve
valuable
reference
facilitate
advancements
application
field.
Язык: Английский