Bioinspired micro‐ and nanostructured systems for cancer therapy DOI Creative Commons
Ruizhen Yang, Bing Zhang,

Xiawei Fei

et al.

MedComm, Journal Year: 2024, Volume and Issue: 5(12)

Published: Nov. 28, 2024

Abstract Numerous organisms in nature have demonstrated enhanced biocompatibility, precise tumor targeting capabilities, and efficient tissue traversal within the human body. Drawing inspiration from these organisms, researchers employed bioengineering, bioconjugation, micro‐ or nanotechnology to fabricate bioinspired nanostructured systems. These systems play a crucial role addressing limitations of conventional anticancer drugs nanomaterials concerning effective penetration physiological barriers, as well selective targeting, thereby leading improved therapeutic efficacy while minimizing nonspecific adverse effects on healthy cells. Consequently, extensive exploration has been undertaken across various cancer treatment modalities with some progressing into preclinical clinical stages. However, our understanding this field remains limited which may impede research progress, translation efforts, practical applications. Therefore, study presents systematic classification for therapy that comprehensively elucidates their sources design principles. Furthermore, it extensively discusses current status efforts identifying prevailing challenges exploring future prospects. This work will establish robust theoretical framework serve valuable reference facilitate advancements application field.

Language: Английский

Plant-derived extracellular vesicles: a synergetic combination of a drug delivery system and a source of natural bioactive compounds DOI Creative Commons

Mattia D. Langellotto,

Giovanna Rassu, Carla Serri

et al.

Drug Delivery and Translational Research, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 28, 2024

Abstract Exosomes are extracellular nanovesicles secreted by all cell types and have been studied to understand treat many human diseases. involved in numerous physiological pathological processes, intercellular communication, the transfer of substances. Over years, several studies explored mammalian-derived exosomes for therapeutic diagnostic uses. Only recently plant-derived vesicles (EVs) attracted attention their ability overcome defects associated with using vesicles, such as safety scale-up issues. The ease large-scale production, low toxicity, immunogenicity, efficient cellular uptake, high biocompatibility, stability these make them attractive drug delivery systems. In addition, native contents proteins, miRNAs secondary metabolites could be exploited pharmaceutical applications combination other drugs. present review intends provide adequate tools studying developing systems based on EVs. Therefore, indications concerning extraction methods, characterisation, loading will offered. Their biological composition content also reported. Finally, current nanocarriers pharmacologically active substances shown. Graphical

Language: Английский

Citations

7
Flos Puerariae-derived exosomes-like nanoparticles ameliorate alcoholic liver disease by targeting IL-11-related signaling pathways and reactive oxygen species DOI
Siyue Li, Shuang Ma, Panpan Wang

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 161896 - 161896

Published: March 1, 2025

Language: Английский

Citations

0
Plant-Derived Extracellular Vesicles: Natural Nanocarriers for Biotechnological Drugs DOI Open Access
Eleonora Calzoni, Agnese Bertoldi, Gaia Cusumano

et al.

Processes, Journal Year: 2024, Volume and Issue: 12(12), P. 2938 - 2938

Published: Dec. 23, 2024

Plant-derived extracellular vesicles (PDEVs) are lipid bilayer nanoparticles, naturally produced by plant cells, with sizes ranging from 50 to 500 nm. Recent studies have highlighted their great potential in the biotechnological and medical fields, due natural origin, high biocompatibility intrinsic therapeutic properties. PDEVs contain a complex biological cargo of proteins, lipids, nucleic acids secondary metabolites, including antioxidants anti-inflammatory molecules, making them ideal for biomedical applications such as drug delivery. These play key role intercellular communication gene regulation, proving be particularly promising personalized medicine. ability improve stability bioavailability, optimizing targeted release minimizing side effects. Despite some challenges, compositional variability need standardized protocols, at gunsight innovative research aimed improving loading capacity specificity. This review aims provide comprehensive overview PDEVs, exploring structure, isolation methods, functional characteristics, applications, highlighting advantages over synthetic nanoparticles animal-derived vesicles, leading an sustainable solution development new approaches.

Language: Английский

Citations

3
Aloe Extracellular Vesicles as Carriers of Photoinducible Metabolites Exhibiting Cellular Phototoxicity DOI Creative Commons
Eleonora Calzoni, Agnese Bertoldi, Alessio Cesaretti

et al.

Cells, Journal Year: 2024, Volume and Issue: 13(22), P. 1845 - 1845

Published: Nov. 7, 2024

The growing interest in plant-origin active molecules with medicinal properties has led to a revaluation of plants the pharmaceutical field. Plant-derived extracellular vesicles (PDEVs) have emerged as promising candidates for next-generation drug delivery systems due their ability concentrate and deliver plethora bioactive molecules. These bilayer membranous vesicles, whose diameter ranges from 30 1000 nm, are released by different cell types play crucial role cross-kingdom communication between humans. Notably, PDEVs demonstrated efficacy treating various diseases, including cancer, alcoholic liver disease, inflammatory bowel disease. However, further research on plant is necessary fully understand traits purposes. This study investigates phototoxic effects (EVs)

Language: Английский

Citations

2
Bioinspired micro‐ and nanostructured systems for cancer therapy DOI Creative Commons
Ruizhen Yang, Bing Zhang,

Xiawei Fei

et al.

MedComm, Journal Year: 2024, Volume and Issue: 5(12)

Published: Nov. 28, 2024

Abstract Numerous organisms in nature have demonstrated enhanced biocompatibility, precise tumor targeting capabilities, and efficient tissue traversal within the human body. Drawing inspiration from these organisms, researchers employed bioengineering, bioconjugation, micro‐ or nanotechnology to fabricate bioinspired nanostructured systems. These systems play a crucial role addressing limitations of conventional anticancer drugs nanomaterials concerning effective penetration physiological barriers, as well selective targeting, thereby leading improved therapeutic efficacy while minimizing nonspecific adverse effects on healthy cells. Consequently, extensive exploration has been undertaken across various cancer treatment modalities with some progressing into preclinical clinical stages. However, our understanding this field remains limited which may impede research progress, translation efforts, practical applications. Therefore, study presents systematic classification for therapy that comprehensively elucidates their sources design principles. Furthermore, it extensively discusses current status efforts identifying prevailing challenges exploring future prospects. This work will establish robust theoretical framework serve valuable reference facilitate advancements application field.

Language: Английский

Citations

0