Influence of gut microbial metabolites on tumor immunotherapy: mechanisms and potential natural products
Frontiers in Immunology,
Год журнала:
2025,
Номер
16
Опубликована: Фев. 24, 2025
In
recent
years,
tumor
immunotherapy
has
made
significant
breakthroughs
in
the
treatment
of
malignant
tumors.
However,
individual
differences
efficacy
have
been
observed
clinical
practice.
There
is
increasing
evidence
that
gut
microbial
metabolites
influence
distal
via
gut-liver
axis,
gut-brain
axis
and
gut-breast
a
process
may
involve
modulating
expression
immune
cells
cytokines
microenvironment
(TME).
this
review,
we
systematically
explore
relationship
between
immunotherapy,
examine
corresponding
natural
products
their
mechanisms
action.
The
in-depth
exploration
research
area
will
provide
new
ideas
strategies
to
enhance
mitigate
adverse
effects.
Язык: Английский
Impact of Lactocaseibacillus (Lactobacillus) paracasei sup. paracasei TISTR 2593 Probiotic Supplementation on the Gut Microbiome of Hypercholesterolemia Patients: A Randomized Controlled Trial
Nutrients,
Год журнала:
2024,
Номер
16(17), С. 2916 - 2916
Опубликована: Сен. 1, 2024
Probiotics
have
shown
potential
in
managing
hypercholesterolemia
and
related
metabolic
conditions.
This
study
evaluated
the
effects
of
Lactocaseibacillus
(Lactobacillus)
paracasei
sup.
TISTR
2593
on
gut
microbiome
health
patients
with
hypercholesterolemia,
was
registered
Thai
Clinical
Trial
Registry
(TCTR
20220917002).
In
a
randomized,
double-blind,
placebo-controlled
trial,
22
hypercholesterolemic
participants
received
either
probiotic
or
placebo
daily
for
90
days.
Fecal
samples
collected
before
after
intervention
revealed
significant
changes,
including
decrease
Subdoligranulum,
linked
to
rheumatoid
arthritis,
an
increase
Flavonifractor,
known
its
anti-inflammatory
properties.
Additionally,
group
exhibited
reduction
low-density
lipoprotein
cholesterol
(LDL-C)
levels.
These
findings
suggest
that
L.
can
modulate
improve
health,
warranting
further
investigation
into
mechanisms
long-term
benefits.
Язык: Английский
Bushen Jiedu Formula alleviates colorectal cancer progression through reducing lncRPPH1 in tumor-derived extracellular vesicles
Shiyun Shao,
Lei Tang,
Wenqing Rong
и другие.
Phytomedicine,
Год журнала:
2025,
Номер
138, С. 156390 - 156390
Опубликована: Янв. 13, 2025
Язык: Английский
Diosmin Alleviates Colitis by Inhibiting PANoptosis of Intestinal Epithelial Cells and Regulating Gut Microbiota and Metabolites
Phytomedicine,
Год журнала:
2025,
Номер
unknown, С. 156671 - 156671
Опубликована: Март 1, 2025
Язык: Английский
Qingjie Fuzheng Granule prevents colitis-associated colorectal cancer by inhibiting abnormal activation of NOD2/NF-κB signaling pathway mediated by gut microbiota disorder
Chinese Herbal Medicines,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 1, 2025
Язык: Английский
Fermented guava (Psidium guajava) by Lactiplantibacillus plantarum NCU0011129 attenuates azoxymethane/dextran sodium sulfate-induced colorectal cancer in mice: Restructuring gut microbiota and enhancing intestinal barrier function
Food Bioscience,
Год журнала:
2025,
Номер
unknown, С. 106672 - 106672
Опубликована: Апрель 1, 2025
Язык: Английский
Biological Roles and Clinical Therapeutic Applications of Tumor-Associated Macrophages in Colorectal Liver Metastasis
Journal of Inflammation Research,
Год журнала:
2024,
Номер
Volume 17, С. 8429 - 8443
Опубликована: Ноя. 1, 2024
Colorectal
cancer
(CRC)
commonly
metastasizes
to
the
liver,
and
this
poses
a
significant
clinical
challenge.
Tumor-associated
macrophages
(TAMs),
key
players
within
TME,
play
role
in
promoting
CRC
metastasis
by
secreting
various
chemokines,
growth
factors,
cytokines.
This
review
not
only
aims
enhance
our
knowledge
of
TAMs'
functions
progression
but
also
examines
innovative
therapeutic
strategies
address
problem
colorectal
liver
(CLM).
By
targeting
TAMs,
we
may
be
able
develop
more
effective
treatments
offer
hope
patients
suffering
from
devastating
disease.
Язык: Английский