Biological Roles and Clinical Therapeutic Applications of Tumor-Associated Macrophages in Colorectal Liver Metastasis DOI Creative Commons
Shenghao Li, Liyuan Hao, Xiaoyu Hu

et al.

Journal of Inflammation Research, Journal Year: 2024, Volume and Issue: Volume 17, P. 8429 - 8443

Published: Nov. 1, 2024

Colorectal cancer (CRC) commonly metastasizes to the liver, and this poses a significant clinical challenge. Tumor-associated macrophages (TAMs), key players within TME, play role in promoting CRC metastasis by secreting various chemokines, growth factors, cytokines. This review not only aims enhance our knowledge of TAMs' functions progression but also examines innovative therapeutic strategies address problem colorectal liver (CLM). By targeting TAMs, we may be able develop more effective treatments offer hope patients suffering from devastating disease.

Language: Английский

Bushen Jiedu Formula alleviates colorectal cancer progression through reducing lncRPPH1 in tumor-derived extracellular vesicles DOI

Shiyun Shao,

Lei Tang,

Wenqing Rong

et al.

Phytomedicine, Journal Year: 2025, Volume and Issue: 138, P. 156390 - 156390

Published: Jan. 13, 2025

Language: Английский

Citations

0
Influence of gut microbial metabolites on tumor immunotherapy: mechanisms and potential natural products DOI Creative Commons
Dongyang Li, Xingguo Lan,

Linyi Xu

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 24, 2025

In recent years, tumor immunotherapy has made significant breakthroughs in the treatment of malignant tumors. However, individual differences efficacy have been observed clinical practice. There is increasing evidence that gut microbial metabolites influence distal via gut-liver axis, gut-brain axis and gut-breast a process may involve modulating expression immune cells cytokines microenvironment (TME). this review, we systematically explore relationship between immunotherapy, examine corresponding natural products their mechanisms action. The in-depth exploration research area will provide new ideas strategies to enhance mitigate adverse effects.

Language: Английский

Citations

0
Diosmin Alleviates Colitis by Inhibiting PANoptosis of Intestinal Epithelial Cells and Regulating Gut Microbiota and Metabolites DOI
Cheng Tan, Zixuan Xiang, Shuo Wang

et al.

Phytomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 156671 - 156671

Published: March 1, 2025

Language: Английский

Citations

0
Qingjie Fuzheng Granule prevents colitis-associated colorectal cancer by inhibiting abnormal activation of NOD2/NF-κB signaling pathway mediated by gut microbiota disorder DOI Open Access
Bin Huang,

Honglin An,

Mengxuan Gui

et al.

Chinese Herbal Medicines, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0
Fermented guava (Psidium guajava) by Lactiplantibacillus plantarum NCU0011129 attenuates azoxymethane/dextran sodium sulfate-induced colorectal cancer in mice: Restructuring gut microbiota and enhancing intestinal barrier function DOI

Xiaoyan Xu,

Shijin Xiong,

Tonghao Du

et al.

Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 106672 - 106672

Published: April 1, 2025

Language: Английский

Citations

0
Impact of Lactocaseibacillus (Lactobacillus) paracasei sup. paracasei TISTR 2593 Probiotic Supplementation on the Gut Microbiome of Hypercholesterolemia Patients: A Randomized Controlled Trial DOI Open Access

Kamonsri Nuankham,

Jaruwan Sitdhipol, Pennapa Chonpathompikunlert

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(17), P. 2916 - 2916

Published: Sept. 1, 2024

Probiotics have shown potential in managing hypercholesterolemia and related metabolic conditions. This study evaluated the effects of Lactocaseibacillus (Lactobacillus) paracasei sup. TISTR 2593 on gut microbiome health patients with hypercholesterolemia, was registered Thai Clinical Trial Registry (TCTR 20220917002). In a randomized, double-blind, placebo-controlled trial, 22 hypercholesterolemic participants received either probiotic or placebo daily for 90 days. Fecal samples collected before after intervention revealed significant changes, including decrease Subdoligranulum, linked to rheumatoid arthritis, an increase Flavonifractor, known its anti-inflammatory properties. Additionally, group exhibited reduction low-density lipoprotein cholesterol (LDL-C) levels. These findings suggest that L. can modulate improve health, warranting further investigation into mechanisms long-term benefits.

Language: Английский

Citations

3
Biological Roles and Clinical Therapeutic Applications of Tumor-Associated Macrophages in Colorectal Liver Metastasis DOI Creative Commons
Shenghao Li, Liyuan Hao, Xiaoyu Hu

et al.

Journal of Inflammation Research, Journal Year: 2024, Volume and Issue: Volume 17, P. 8429 - 8443

Published: Nov. 1, 2024

Colorectal cancer (CRC) commonly metastasizes to the liver, and this poses a significant clinical challenge. Tumor-associated macrophages (TAMs), key players within TME, play role in promoting CRC metastasis by secreting various chemokines, growth factors, cytokines. This review not only aims enhance our knowledge of TAMs' functions progression but also examines innovative therapeutic strategies address problem colorectal liver (CLM). By targeting TAMs, we may be able develop more effective treatments offer hope patients suffering from devastating disease.

Language: Английский

Citations

0