Miquelianin inhibits IAV infection via the MAPK signaling pathway both in vitro and in vivo

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Март 17, 2025

Influenza is an acute respiratory infectious disease primarily transmitted through airborne droplets. The prevalence and spread of influenza viruses have significant impacts on global economic development public health. Current prevention control strategies for virus infections mainly rely vaccines antiviral drugs. However, vaccine efficacy limited by the antigenic drift mutation characteristics viruses, while drug resistance increasingly prevalent. Therefore, there urgent need novel agents. Flavonoids, widely distributed in plants, possess various potent biological properties, including antioxidant, anti-inflammatory, antibacterial, anticancer activities, which contribute to management numerous diseases. This study aims investigate vitro vivo anti-influenza A activity quercetin, taxifolin, miquelianin, as well their underlying. In infection model (MDCK cells) mouse lethal Infuenza were used evaluate taxifolin miquelianin. Subsequently, we applied network pharmacology elucidate mechanism action validate findings Miquelianin effectively inhibits replication H1N1-UI182 both provides protection against mice. Compared virus-infected controls, miquelianin reduces lung injury. Furthermore, inhibiting MAPK signaling pathway, prevents overproduction cytokines, such IL-6 IL-1β, induced viral infection, thereby alleviating inflammatory responses. a monomer extracted from traditional Chinese medicine, exhibiting inhibitory effects injury mitigation.

Язык: Английский

Unraveling the therapeutic potential of Satureja nabateorum extract: inducing apoptosis and cell cycle arrest through p53, Bax/Bcl-2, and caspase-3 pathways in human malignant cell lines, with in silico insights

Journal of Biomolecular Structure and Dynamics, Год журнала: 2024, Номер unknown, С. 1 - 18

Опубликована: Окт. 26, 2024

, known as Nabatean savory is a Lamiaceae plant native to the Arabian Peninsula, specifically in mountainous regions of Saudi Arabia. The study aims investigate phytochemical components

Язык: Английский