Whole genome level analysis of the DEATH protein superfamily in sheep (Ovis aries) and their coordination relationship in regulating lactation DOI Creative Commons
Zhongchao Gai, Songhao Hu,

Yujiao He

и другие.

Chemical and Biological Technologies in Agriculture, Год журнала: 2023, Номер 10(1)

Опубликована: Май 10, 2023

Abstract Background Sheep milk is a nutritional and health-promoting food source for humans. The DEATH superfamily conserved protein family, some of its members are closely related to lactation. Systematic studies the important further understanding functions in mammary gland during lactation; however, there currently lacking. Results Herein, 74 were identified sheep, phylogenetic analyses indicated that four subfamilies strongly correlated evolution. Ka/Ks calculations demonstrated negative selection was primary pressure acting on members; immune-related gene IFI203 undergoing strong positive sheep. Furthermore, late pregnancy lactation period, these genes exhibited similar expression patterns under different conditions gland, positively patterns. Additionally, half or more upregulated which implied their crucial roles Conclusions current research contributes better evolutionary characteristics sheep lactation, it also provides potential target molecular breeding dairy Graphical

Язык: Английский

Proteomics and Peptidomics As a Tool to Compare the Proteins and Endogenous Peptides in Human, Cow, and Donkey Milk DOI
Jianting Ning, Mei Yang, Wanting Liu

и другие.

Journal of Agricultural and Food Chemistry, Год журнала: 2023, Номер 71(44), С. 16435 - 16451

Опубликована: Окт. 26, 2023

Cow's milk is the most widely used ingredient in infant formulas. However, its specific protein composition can cause allergic reactions. Finding alternatives to replace cow's and fill nutritional gap with human essential for health of infants. Proteomic peptidomic techniques have supported elucidation milk's ingredients. Recently, omics approaches attracted increasing interest investigation because their high throughput, precision, sensitivity, reproducibility. This review offers a significant overview recent developments proteomics peptidomics study differences human, cow, donkey milk. All three types milks were identified critical biological functions health, particularly Donkey proteins closer milk, less likely reactions, may be developed as novel raw materials formula powders.

Язык: Английский

Процитировано

16
Emerging innovations on exosome-based onco-therapeutics DOI Creative Commons
Xiaofeng Dai, Yongju Ye, Fu-le He

и другие.

Frontiers in Immunology, Год журнала: 2022, Номер 13

Опубликована: Авг. 31, 2022

Exosomes, nano-sized extracellular vesicles for intercellular communications, are gaining rapid momentum as a novel strategy the diagnosis and therapeutics of spectrum diseases including cancers. Secreted by various cell sources, exosomes pertain numerous functionalities from their parental cells have enhanced stability that enable them with many features favorable clinical use commercialization. This paper focuses on possible roles in cancer reviews current exosome-based innovations toward management challenges limit translation. Importantly, this casts insights how cold atmospheric plasma, an emerging anticancer strategy, may aid onco-therapeutics improved control over

Язык: Английский

Процитировано

22
Cellular mechanisms underlying toxic effects of pesticides on mammary gland DOI
Mihyun Jeong, Jinho Seo,

C.‐S. Park

и другие.

Molecular & Cellular Toxicology, Год журнала: 2025, Номер unknown

Опубликована: Янв. 27, 2025

Язык: Английский

Процитировано

0
Transporters and drug secretion into human breastmilk DOI
Jessica L. Beers, Mary F. Hébert,

Joanne Wang

и другие.

Expert Opinion on Drug Metabolism & Toxicology, Год журнала: 2025, Номер unknown, С. 1 - 20

Опубликована: Фев. 2, 2025

Medication use is highly prevalent in breastfeeding persons, posing potential risks for drug exposure to nursing infants. Transporters the lactating mammary gland carry pharmacological and toxicological significance, as they can mediate active transfer of drugs nutrients into breastmilk. In this narrative review, we searched compiled current knowledge on transport human from literature indexed PubMed (current 25 October 2024), clinical evidence demonstrating milk provided. vitro vivo models are outlined brief known transporters at blood-milk barrier their relevance concentrations described detail. Although data show that membrane multiple breast milk, our ability predict these limited. Improving understanding transporter biology pharmacology crucial developing which will support clinicians individuals making rational decisions balance benefits

Язык: Английский

Процитировано

0
UNIQUE LIPID SIGNATURES IN VIRAL ENVELOPES ORIGINATING FROM HOST MEMBRANES DOI
Arturo Tozzi

Next research., Год журнала: 2025, Номер unknown, С. 100460 - 100460

Опубликована: Июнь 1, 2025

Процитировано

0
Nutritional intervention and its effects on colostrum fatty acids and amino acids profile in lactating yaks in first week of lactation DOI
Zhenyu Zhu,

Zhanming Yang,

Xiaotian Li

и другие.

Food Science of Animal Products, Год журнала: 2025, Номер 3(3), С. 9240122 - 9240122

Опубликована: Июнь 3, 2025

Язык: Английский

Процитировано

0
Mammary lipid secretion: a reassessment DOI Open Access

F. B. P. Wooding

Journal of Dairy Research, Год журнала: 2023, Номер 90(1), С. 28 - 37

Опубликована: Фев. 1, 2023

Mammary lipid secretion is generally held to be unique and remarkably uniform between the many different orders of mammals. It produces a unit membrane-bounded milk fat globule (MFG). The membrane separated from lipoprotein boundary what was cytoplasmic droplet (CLD) by layer proteins. In 3-8% MFG in all species examined this widens include organelles which are referred as 'crescents'. This defines apocrine indicating closely regulated process minimises loss mammary epithelial cell (MEC) cytoplasm. nature might expected since evolution gland considered an secreting skin gland. short Research Reflection review designed investigate exact interactions allow such efficient secretion. There two main scenarios: one assumes that observed close association CLD GV results being released consequence sequential exocytosis content associated GV. second MEC apical plasmalemma interact some way causes rise out cytoplasm enveloped plasmalemma. Here I present evidence for possibilities. first scenario favoured, but cannot ruled out.

Язык: Английский

Процитировано

8
Simple methods for measuring milk exosomes using fluorescent compound GIF-2250/2276 DOI

Saho Furukawa,

Kyoka Kawaguchi,

Kotomi Chikama

и другие.

Biochemical and Biophysical Research Communications, Год журнала: 2024, Номер 696, С. 149505 - 149505

Опубликована: Янв. 9, 2024

Язык: Английский

Процитировано

3
Exploring of exosomes in pathogenesis, diagnosis and therapeutic of osteonecrosis of the femoral head: the mechanisms and signaling pathways DOI

Sheqing Chen,

Jin Liu,

Nuoya Zhang

и другие.

Biomedical Materials, Год журнала: 2024, Номер 19(5), С. 052006 - 052006

Опубликована: Авг. 9, 2024

Osteonecrosis of the femoral head (ONFH) is a refractory disease affecting young adults, resulting in severe hip pain, collapse, and disabling dysfunction. By far, underlying mechanism its pathology unclear, still lack mature effective treatment. Exosomes, regulator cell-cell communication, their cargos may vary response to different physiological or pathological conditions. To date, many studies have demonstrated that exosomes potential become diagnostic marker therapeutic agent human diseases including ONFH. As cell-free agent, are becoming promising tool within this field due crucial role osteogenesis angiogenesis recent decades. Usually, from ONFH tissues could promote damage, while stem cells derived delay repair necrosis. Herein, we describe properties exosomes, discuss effect on pathogenesis, diagnosis, treatment ONFH, examine involvement signaling pathways. We also propose our suggestions for future research hope provide strategy patients with

Язык: Английский

Процитировано

3
Profiling several key milk miRNAs and analysing their signalling pathways in dairy sheep breeds during peak and late lactation DOI Creative Commons
Esra Duman, Özge Özmen, Selim Kul

и другие.

Veterinary Medicine and Science, Год журнала: 2024, Номер 10(4)

Опубликована: Июнь 25, 2024

Abstract Background The comprehensive understanding of microRNAs (miRNAs) in sheep milk during various lactation periods and their impact on yield composition remains limited. Objectives This study aimed to investigate the expression patterns four highly expressed miRNAs association with parameters peak late stages. Methods A total 40 healthy 4‐year‐old Akkaraman ( n = 20) Awassi ewes registered Ministry Agriculture Forestry Republic Türkiye were used present study. For miRNA isolation from milk, Qiagen miRNeasy Serum/Plasma Advanced Kit was utilised following manufacturer's instructions. levels assessed using PCR Assays. Results significant fold changes oar‐miR‐30a‐5p, oar‐miR‐148a oar‐miR‐181a observed between breed. Conversely, only oar‐miR‐30a‐5p exhibited statistically breed same periods. Furthermore, oar‐miR‐21‐5p demonstrated a change exclusively compared ewes. Conclusions findings suggest that analysed is influenced by both stage different breeds. offers valuable insights into relationship key expressions lactation, contributing existing knowledge this field.

Язык: Английский

Процитировано

2