Chemical and Biological Technologies in Agriculture,
Journal Year:
2023,
Volume and Issue:
10(1)
Published: May 10, 2023
Abstract
Background
Sheep
milk
is
a
nutritional
and
health-promoting
food
source
for
humans.
The
DEATH
superfamily
conserved
protein
family,
some
of
its
members
are
closely
related
to
lactation.
Systematic
studies
the
important
further
understanding
functions
in
mammary
gland
during
lactation;
however,
there
currently
lacking.
Results
Herein,
74
were
identified
sheep,
phylogenetic
analyses
indicated
that
four
subfamilies
strongly
correlated
evolution.
Ka/Ks
calculations
demonstrated
negative
selection
was
primary
pressure
acting
on
members;
immune-related
gene
IFI203
undergoing
strong
positive
sheep.
Furthermore,
late
pregnancy
lactation
period,
these
genes
exhibited
similar
expression
patterns
under
different
conditions
gland,
positively
patterns.
Additionally,
half
or
more
upregulated
which
implied
their
crucial
roles
Conclusions
current
research
contributes
better
evolutionary
characteristics
sheep
lactation,
it
also
provides
potential
target
molecular
breeding
dairy
Graphical
Journal of Agricultural and Food Chemistry,
Journal Year:
2023,
Volume and Issue:
71(44), P. 16435 - 16451
Published: Oct. 26, 2023
Cow's
milk
is
the
most
widely
used
ingredient
in
infant
formulas.
However,
its
specific
protein
composition
can
cause
allergic
reactions.
Finding
alternatives
to
replace
cow's
and
fill
nutritional
gap
with
human
essential
for
health
of
infants.
Proteomic
peptidomic
techniques
have
supported
elucidation
milk's
ingredients.
Recently,
omics
approaches
attracted
increasing
interest
investigation
because
their
high
throughput,
precision,
sensitivity,
reproducibility.
This
review
offers
a
significant
overview
recent
developments
proteomics
peptidomics
study
differences
human,
cow,
donkey
milk.
All
three
types
milks
were
identified
critical
biological
functions
health,
particularly
Donkey
proteins
closer
milk,
less
likely
reactions,
may
be
developed
as
novel
raw
materials
formula
powders.
Frontiers in Immunology,
Journal Year:
2022,
Volume and Issue:
13
Published: Aug. 31, 2022
Exosomes,
nano-sized
extracellular
vesicles
for
intercellular
communications,
are
gaining
rapid
momentum
as
a
novel
strategy
the
diagnosis
and
therapeutics
of
spectrum
diseases
including
cancers.
Secreted
by
various
cell
sources,
exosomes
pertain
numerous
functionalities
from
their
parental
cells
have
enhanced
stability
that
enable
them
with
many
features
favorable
clinical
use
commercialization.
This
paper
focuses
on
possible
roles
in
cancer
reviews
current
exosome-based
innovations
toward
management
challenges
limit
translation.
Importantly,
this
casts
insights
how
cold
atmospheric
plasma,
an
emerging
anticancer
strategy,
may
aid
onco-therapeutics
improved
control
over
Biomedical Materials,
Journal Year:
2024,
Volume and Issue:
19(5), P. 052006 - 052006
Published: Aug. 9, 2024
Osteonecrosis
of
the
femoral
head
(ONFH)
is
a
refractory
disease
affecting
young
adults,
resulting
in
severe
hip
pain,
collapse,
and
disabling
dysfunction.
By
far,
underlying
mechanism
its
pathology
unclear,
still
lack
mature
effective
treatment.
Exosomes,
regulator
cell-cell
communication,
their
cargos
may
vary
response
to
different
physiological
or
pathological
conditions.
To
date,
many
studies
have
demonstrated
that
exosomes
potential
become
diagnostic
marker
therapeutic
agent
human
diseases
including
ONFH.
As
cell-free
agent,
are
becoming
promising
tool
within
this
field
due
crucial
role
osteogenesis
angiogenesis
recent
decades.
Usually,
from
ONFH
tissues
could
promote
damage,
while
stem
cells
derived
delay
repair
necrosis.
Herein,
we
describe
properties
exosomes,
discuss
effect
on
pathogenesis,
diagnosis,
treatment
ONFH,
examine
involvement
signaling
pathways.
We
also
propose
our
suggestions
for
future
research
hope
provide
strategy
patients
with
Expert Opinion on Drug Metabolism & Toxicology,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 20
Published: Feb. 2, 2025
Medication
use
is
highly
prevalent
in
breastfeeding
persons,
posing
potential
risks
for
drug
exposure
to
nursing
infants.
Transporters
the
lactating
mammary
gland
carry
pharmacological
and
toxicological
significance,
as
they
can
mediate
active
transfer
of
drugs
nutrients
into
breastmilk.
In
this
narrative
review,
we
searched
compiled
current
knowledge
on
transport
human
from
literature
indexed
PubMed
(current
25
October
2024),
clinical
evidence
demonstrating
milk
provided.
vitro
vivo
models
are
outlined
brief
known
transporters
at
blood-milk
barrier
their
relevance
concentrations
described
detail.
Although
data
show
that
membrane
multiple
breast
milk,
our
ability
predict
these
limited.
Improving
understanding
transporter
biology
pharmacology
crucial
developing
which
will
support
clinicians
individuals
making
rational
decisions
balance
benefits
Journal of Dairy Research,
Journal Year:
2023,
Volume and Issue:
90(1), P. 28 - 37
Published: Feb. 1, 2023
Mammary
lipid
secretion
is
generally
held
to
be
unique
and
remarkably
uniform
between
the
many
different
orders
of
mammals.
It
produces
a
unit
membrane-bounded
milk
fat
globule
(MFG).
The
membrane
separated
from
lipoprotein
boundary
what
was
cytoplasmic
droplet
(CLD)
by
layer
proteins.
In
3-8%
MFG
in
all
species
examined
this
widens
include
organelles
which
are
referred
as
'crescents'.
This
defines
apocrine
indicating
closely
regulated
process
minimises
loss
mammary
epithelial
cell
(MEC)
cytoplasm.
nature
might
expected
since
evolution
gland
considered
an
secreting
skin
gland.
short
Research
Reflection
review
designed
investigate
exact
interactions
allow
such
efficient
secretion.
There
two
main
scenarios:
one
assumes
that
observed
close
association
CLD
GV
results
being
released
consequence
sequential
exocytosis
content
associated
GV.
second
MEC
apical
plasmalemma
interact
some
way
causes
rise
out
cytoplasm
enveloped
plasmalemma.
Here
I
present
evidence
for
possibilities.
first
scenario
favoured,
but
cannot
ruled
out.
Veterinary Medicine and Science,
Journal Year:
2024,
Volume and Issue:
10(4)
Published: June 25, 2024
Abstract
Background
The
comprehensive
understanding
of
microRNAs
(miRNAs)
in
sheep
milk
during
various
lactation
periods
and
their
impact
on
yield
composition
remains
limited.
Objectives
This
study
aimed
to
investigate
the
expression
patterns
four
highly
expressed
miRNAs
association
with
parameters
peak
late
stages.
Methods
A
total
40
healthy
4‐year‐old
Akkaraman
(
n
=
20)
Awassi
ewes
registered
Ministry
Agriculture
Forestry
Republic
Türkiye
were
used
present
study.
For
miRNA
isolation
from
milk,
Qiagen
miRNeasy
Serum/Plasma
Advanced
Kit
was
utilised
following
manufacturer's
instructions.
levels
assessed
using
PCR
Assays.
Results
significant
fold
changes
oar‐miR‐30a‐5p,
oar‐miR‐148a
oar‐miR‐181a
observed
between
breed.
Conversely,
only
oar‐miR‐30a‐5p
exhibited
statistically
breed
same
periods.
Furthermore,
oar‐miR‐21‐5p
demonstrated
a
change
exclusively
compared
ewes.
Conclusions
findings
suggest
that
analysed
is
influenced
by
both
stage
different
breeds.
offers
valuable
insights
into
relationship
key
expressions
lactation,
contributing
existing
knowledge
this
field.
Cell Biology International,
Journal Year:
2023,
Volume and Issue:
47(6), P. 1106 - 1117
Published: Feb. 14, 2023
Palmitic
acid
(PA)
can
stimulate
milk
fat
synthesis
in
mammary
gland,
but
the
specific
mechanism
is
still
unclear.
In
our
research,
we
aim
to
explore
role
and
corresponding
of
AT-rich
interaction
domain
3A
(ARID3A)
stimulated
by
PA.
We
found
that
ARID3A
protein
level
mouse
gland
tissues
during
lactation
was
much
higher
than
puberty
involution.
knockdown
gene
activation
showed
triglycerides
cholesterol
HC11
cells,
secretion
free
fatty
acids
from
cells
lipid
droplet
formation
cells.
also
promoted
expression
maturation
SREBP1
PA
a
dose-dependent
manner,
PI3K
inhibitor
LY294002
blocked
stimulation
on
expression.
maturation.
further
localized
nucleus
this
localization,
mRNA
SREBP1.
To
sum
up,
data
reveal
key
mediator
for
promote
epithelial
