American Journal of Nuclear Medicine and Molecular Imaging, Год журнала: 2024, Номер 14(6), С. 371 - 390
Опубликована: Янв. 1, 2024
Язык: Английский
International Journal of Community Medicine and Public Health, Год журнала: 2025, Номер unknown
Опубликована: Янв. 23, 2025
Physicians face challenges in diagnosing and managing of neuromuscular neurodegenerative diseases, such as amyotrophic lateral sclerosis Huntington’s disease, they are rare, clinically variable, often misdiagnosed by traditional diagnostic methods. To overcome these challenges, multimodality imaging, combining techniques like magnetic resonance imaging (MRI), computed tomography (CT), positron emission (PET), ultrasound, has emerged to provide complementary structural, functional, molecular data. This review discusses the roles diagnosing, monitoring, rare diseases. Structural changes neural connectivity identified MRI, metabolic abnormalities detected PET. Real time evaluation nerve muscle is provided whereas CT aids respiratory function skeletal structures. These methods combined improve accuracy further understanding disease mechanisms. Emerging multimodal techniques, ultra-high-field MRI hybrid PET-MRI systems, being developed greater resolution efficiency. Multimodality a critical tool improving care patients with disorders. However, its widespread use hindered high costs, limited access, need for standardized protocols validation. Future directions include development biomarkers, integration other methods, artificial intelligence analyze complex
Язык: Английский
Процитировано
0
Instruments, Год журнала: 2025, Номер 9(1), С. 2 - 2
Опубликована: Фев. 5, 2025
We designed and evaluated the performance of a high-resolution large-area detector for positron emission tomography (PET) based on crystal assembly readout using wavelength-shifting (WLS) fibers, offering cost-effective alternative to direct monolithic crystals with photodetectors. The considered geometries were made up 4 × assemblies LuY2SiO5:Ce (LYSO) scintillators, each surface area 50 mm2 thickness 7 or 15 mm, which optically coupled together optical adhesive. was square cross-sections orthogonal fibers placed top bottom assembly. To evaluate characteristics novel detector, we used GEANT4 perform photon transport in WLS fibers. simulation results show that best position resolution achieved 1.6 ± 0.4 mm full width at half maximum (FWHM) 4.2 0.6 tenth (FWTM) 1.7 FWHM 6.0 FWTM mm. Compared photosensor readout, can drastically reduce number photosensors required while covering larger sensitive detection area. In proposed design, 2N photodetectors are cover same image instead N2 readout. This design allows development compact an expanded effective field view reduced cost.
Язык: Английский
Процитировано
0
Journal of Molecular Neuroscience, Год журнала: 2025, Номер 75(1)
Опубликована: Март 13, 2025
Abstract Neurodegenerative disorders, including Alzheimer’s disease (AD), Parkinson’s (PD), multiple sclerosis (MS), and amyotrophic lateral (ALS), are characterized by the progressive gradual degeneration of neurons. The prevalence rates these disorders rise significantly with age. As life spans continue to increase in many countries, number cases is expected grow foreseeable future. Early precise diagnosis, along appropriate surveillance, continues pose a challenge. high heterogeneity neurodegenerative diseases calls for more accurate definitive biomarkers improve clinical therapy. Cell-free DNA (cfDNA), fragmented released into bodily fluids via apoptosis, necrosis, or active secretion, has emerged as promising non-invasive diagnostic tool various diseases. cfDNA can serve an indicator ongoing cellular damage mortality, neuronal loss, may provide valuable insights processes, progression, therapeutic responses. This review will first cover key aspects then examine recent advances its potential use biomarker disorders.
Язык: Английский
Процитировано
0
Stroke and Vascular Neurology, Год журнала: 2024, Номер unknown, С. svn - 003504
Опубликована: Авг. 28, 2024
Numerous seemingly promising cerebroprotectants previously validated in rodents almost all have failed stroke clinical trials. The failure of translation strikes an essential need to employ more ideal animal models research. Compared with the most commonly used rodent stroke, non-human primates (NHPs) are far comparable humans regarding brain anatomy, functionality and pathological features. aim this perspective was summarise advantages NHPs over rodents, discuss current limitations models, cast outlook on future development preclinical
Язык: Английский
Процитировано
1
npj Parkinson s Disease, Год журнала: 2024, Номер 10(1)
Опубликована: Сен. 10, 2024
Язык: Английский
Процитировано
1
Journal of Nuclear Medicine, Год журнала: 2024, Номер unknown, С. jnumed.124.268451 - jnumed.124.268451
Опубликована: Ноя. 14, 2024
Brain aging is a pivotal component of the overall process, characterized by progressive loss physiologic and cellular functions, which contributes to cognitive decline increased susceptibility neurodegenerative disorders ([1][1]). Understanding characterizing
Язык: Английский
Процитировано
1
Опубликована: Сен. 25, 2024
Язык: Английский
Процитировано
0
American Journal of Nuclear Medicine and Molecular Imaging, Год журнала: 2024, Номер 14(6), С. 371 - 390
Опубликована: Янв. 1, 2024
Язык: Английский
Процитировано
0