Abstract
Due
to
drug‐resistant
bacteria,
antimicrobial
composite
materials
that
will
replace
antibiotics
are
among
the
current
research
topics.
In
this
study,
environmentally‐friendly,
low‐cost,
easy‐to‐synthesize
chitosan/silk
sericin/silver
nanoparticles
(Cht/SS/AgNPs)
membranes
were
obtained
for
use
in
antibacterial
applications.
For
material
synthesis,
firstly,
AgNPs
by
mixing
solution
of
2
%
sericin
(at
pH
11)‐10
mM
AgNO3
at
100
°C
with
hydrothermal
method
and
formation
was
confirmed
UV‐Vis
measurements.
Then,
sericin/AgNPs
added
chitosan
solutions
different
ratios
Cht/SS/AgNPs
composites
solvent
casting
method.
The
final
forms
characterized
fourier
transform
infrared
spectroscopy
(FTIR),
scanning
electron
microscopy
(SEM)‐energy
dispersive
X‐ray
(EDS),
thermogravimetric
analysis
(TGA).
Water
retention
capacities
mechanical
properties
also
determined.
Finally,
biocompatibility
evaluated
disc
diffusion
test
on
Escherichia
coli
Staphylococcus
aureus
MTT
L929
fibroblast
cell
line,
respectively.
had
homogeneous
appearance,
high
swelling
ratios,
good
properties.
showed
excellent
activity,
especially
S.
biocompatibility.
summary,
can
be
used
as
an
alternative
polymeric
wound‐dressing
or
functional
packaging
materials.
Advanced Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 17, 2024
Poly(lactic
acid)
(PLA)
is
a
representative
biobased
and
biodegradable
aliphatic
polyester
front-runner
among
sustainable
materials.
As
semicrystalline
thermoplastic,
PLA
exhibits
excellent
mechanical
physical
properties,
attracting
considerable
attention
in
commodity
medical
fields.
Stereochemistry
key
factor
affecting
PLA's
to
this
end,
the
engineering
of
microstructure
for
tailored
material
properties
has
been
an
active
area
research
over
decade.
This
Review
first
covers
basic
structural
variety
PLA.
A
perspective
on
current
states
stereocontrolled
synthesis
as
well
relationships
between
structures
stereosequences
are
included,
with
emphasis
record
regularity
properties.
At
last,
state-of-the-art
examples
high-performance
PLA-based
materials
within
array
applications
given,
including
packaging,
fibers,
textiles,
healthcare
electronic
devices.
Among
various
stereo-regular
sequences
PLA,
poly(L-lactic
(PLLA)
most
prominent
category
myriad
unique
applications.
In
regard,
cutting-edge
PLLA
mainly
overviewed
review.
same
time,
new
developed
based
other
highlighted,
which
holds
potential
wide
Chemical Communications,
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 1, 2024
This
review
summarizes
the
hierarchical
structure
and
multifaceted
properties
of
natural
silk
fibers,
provides
an
in-depth
analysis
their
extensive
applications
in
realms
biomedicine
advanced
smart
fiber
technology.
Advanced Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 3, 2024
Abstract
Hydrogen‐bonded
organic
frameworks
(HOFs)
are
emerging
as
multifunctional
materials
with
exceptional
biocompatibility,
abundant
active
sites,
and
tunable
porosity,
which
highly
beneficial
for
advanced
wound
care.
However,
a
significant
challenge
involves
transforming
pristine
HOFs
powders
into
lightweight,
ultrathin,
freestanding
membranes
compatible
soft
biological
systems.
Herein,
the
study
successfully
develops
shape‐adaptive
HOF‐based
matrix
(HMMs)
using
polymer‐assisted
liquid‐air
interface
technique.
The
HMMs
conform
seamlessly
to
tissues
of
different
sizes
shapes,
effectively
stopping
bleeding,
provide
high
water‐vapor
permeability.
Notably,
both
in
vitro
vivo
studies
mice
models
demonstrated
that
these
tissue‐conformable
significantly
accelerate
healing
by
modulating
inflammatory
environment
injured
tissue
promoting
rapid
re‐epithelialization.
Furthermore,
RNA‐seq
analysis
mechanistic
revealed
reduce
inflammation
facilitate
transition
from
proliferative
stage
remodeling
skin
development.
This
work
not
only
opens
up
new
avenues
care
but
also
establishes
foundation
hybridizing
polymers
wide
range
potential
applications.
Advanced Functional Materials,
Год журнала:
2024,
Номер
34(37)
Опубликована: Май 29, 2024
Abstract
The
emerging
mechanically
active
wound
dressing
has
been
perceived
as
one
of
the
most
effective
strategies
to
accelerate
closure
in
a
non‐invasive
manner.
However,
development
with
body
temperature‐stimulated
shrinkage
behavior
and
superior
mechanical
capability
is
still
severe
challenge.
Here,
thermal‐shrinkable,
stretchable,
tough
fibrous
tape
developed
via
construction
“stiff‐elastic”
binary
component,
well
manipulation
fiber
stretching
phase
separation.
resultant
polyurethane
(PU)/polyvinyl
butyral
(PVB)
membrane
(FM)
shows
rapid
considerable
70.0%
after
exposure
at
37
°C
for
12
h.
shrunk
PU/PVB
FMs
exhibit
excellent
performance
including
high
elongation
364.4%,
large
toughness
26.6
MJ
m
−3
thermal‐recoverable
80.4%
71.8%
restoration
stress
dissipated
energy
respectively.
vivo
study
rat
full‐thickness
skin
model
2
cm‐diameter
circular
wounds
demonstrates
that
thermal‐shrinkable
can
enhance
contraction
healing.
Furthermore,
ex
rabbit
organ
indicates
possibility
defect
diverse
tissues.
This
work
may
offer
promising
way
temperature‐triggered
dressings
defects
repair.
ACS Applied Materials & Interfaces,
Год журнала:
2024,
Номер
16(33), С. 43180 - 43188
Опубликована: Авг. 7, 2024
The
development
of
bioadhesives
with
strong
adhesion
and
on-demand
adhesion-detachment
behavior
is
still
critically
important
challenging
for
facilitating
painless
damage-free
removal
in
clinical
applications.
In
this
work,
the
first
time,
we
report
easy
fabrication
novel
polyurethane-urea
(PUU)-based
thermoresponsive
detachment
behavior.
PUU
copolymer
was
synthesized
by
a
simple
copolymerization
low-molecular-weight,
hydrophilic,
biocompatible
poly(ethylene
glycol),
glyceryl
monolaurate
(GML,
special
chain
extender
long
side
hydrophobic
alkyl
group),
isophorone
diisocyanate
(IPDI).
Here,
GML
expected
to
not
only
adjust
temperature-dependent
but
also
act
as
an
internal
plasticizer.
By
adjustment
water
content,
strength
15
wt
%
water-containing
film
toward
porcine
skin
high
55
kPa
energy
128
J/m
IGI Global eBooks,
Год журнала:
2025,
Номер
unknown, С. 367 - 412
Опубликована: Апрель 25, 2025
Because
biomaterials
can
improve
tissue
repair
and
regeneration,
their
use
in
wound
healing
has
drawn
much
attention.
Biomaterials
facilitate
cellular
connections,
create
favorable
microenvironments,
offer
mechanical
support,
making
them
vital
for
promoting
healing.
These
materials
fall
into
three
categories:
natural,
synthetic,
hybrid.
Natural
polymers
such
as
collagen,
alginate,
chitosan
mimic
the
extracellular
matrix
biocompatibility,
while
synthetic
like
PLGA
provide
adjustable
qualities
strength
degradation
rates.
Advanced
hydrogels,
nanoparticles,
electrospun
fibers
enhance
moisture
retention,
control
drug
release,
reduce
infection.
They
release
bioactive
chemicals
growth
factors
antimicrobial
peptides,
preventing
chronic
wounds.
This
chapter
examines
various
used
healing,
therapeutic
uses,
modes
of
action,
well
future
developments
challenges
design,
scalability.
Tissue
adhesives
are
increasingly
sought
after
for
their
potential
to
minimize
invasiveness,
simplify
surgical
procedures,
and
reduce
operative
times;
however,
conventional
polyacrylamide
(PAM)-based
hydrogels
often
hindered
by
irreversible
bonding,
which
limits
reusability
compromises
both
mechanical
integrity
self-healing
ability.
Motivated
the
natural
adhesion
mechanisms
of
mussels,
we
have
developed
an
innovative
tissue
adhesive
hydrogel
incorporating
polydopamine
(PDA)
cysteine
(Cys)
into
a
PAM
matrix
via
free
radical
polymerization,
with
polyethylene
glycol
diacrylate
(PEGDA)
serving
as
effective
cross-linker.
In
our
system,
PDA
contributes
essential
catechol
groups
strong
adhesion,
while
Cys
not
only
preserves
these
from
oxidation
but
also
enhances
hydrophilic
interactions,
resulting
in
PDA-Cys-PAM
tensile
strength
23.4-30.7
kPa,
fracture
elongation
628-706%,
recovery
48%.
Significantly,
seamless
integration
nanoclay
network
further
reinforces
its
structure
improves
energy
dissipation,
leading
marked
enhancement
performance─evidenced
increase
rate
71.9%─without
compromising
inherent
properties.
Moreover,
vitro
assays
NIH3T3
cells
demonstrate
excellent
biocompatibility,
underscoring
this
synergistic
design.
Overall,
work
elucidates
distinct
cooperative
roles
PDA,
Cys,
represents
significant
advancement
design
reusable,
high-performance
applications
repair
regeneration.
