Nanozyme‐Engineered Hyaluronic Acid Adhesives Loading Platelet‐Rich Plasma for Multilayered Osteoarthritis Treatment with Pain‐Relief Effect DOI
Yiyang Zhao,

Wanglin Duan,

Bin Zhu

и другие.

Advanced Functional Materials, Год журнала: 2024, Номер unknown

Опубликована: Дек. 23, 2024

Abstract Osteoarthritis (OA) is the most common degenerative joint disease, causing pain, disability, and economic strain. Combining nanozymes with dopamine (DOPA)‐based adhesives offers a promising approach to effectively modulate microenvironment of OA‐affected tissues. However, traditional fabrication methods DOPA‐based often involve external oxidants or curing agents, which can introduce additional oxidative stress, posing systemic risks. Here, different enzyme‐catalyzed activities platinum–copper (PtCu) at pH values are utilized directly catalyze cross‐linking DOPA‐modified hyaluronic acid (HAD), representing new polymerization method for phenol‐based bioadhesives. The resulting adhesive (HAD/PtCu/platelet‐rich plasma (PRP)), when combined PRP, mitigates generation proinflammatory factors, scavenges reactive oxygen species, boosts hypoxic chemotaxis chondrocytes, stimulates chondrocyte proliferation migration, protects interleukin‐1β‐treated human articular C28/I2 cells from further OA advancement. Additionally, in vivo assessments show that HAD/PtCu/PRP significantly alleviates pain improves knee osteoarthritic rats. These findings suggest provides alternative therapy.

Язык: Английский

Tribology in Nature: Inspirations for Advanced Lubrication Materials DOI Open Access
Chenxi Qin, Hao Yang, Yaqiong Lü

и другие.

Advanced Materials, Год журнала: 2025, Номер unknown

Опубликована: Фев. 19, 2025

Abstract Friction‐induced energy consumption is a significant global concern, driving researchers to explore advanced lubrication materials. In nature, vital for the life cycle of animals, plants, and humans, playing key roles in movement, predation, decomposition. After billions years evolution, natural exhibits remarkable professionalism, high efficiency, durability, intelligence, offering valuable insights designing This review focuses on mechanisms organisms advancements biomimetic soft matter It begins by summarizing common biological behaviors their underlying mechanisms, followed current design strategies The then outlines development performance these materials based different strategies. Finally, it discusses potential research directions prospects will be resource advancing

Язык: Английский

Процитировано

2

Black phosphorus nanosheet dotted with Fe3O4-PDA nanoparticles: A novel lubricant additive for tribological applications DOI
Xing Xu, Fenghua Su, Yu Han

и другие.

Tribology International, Год журнала: 2025, Номер unknown, С. 110607 - 110607

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

1

Lubrication for Osteoarthritis: From Single-Function to Multifunctional Lubricants DOI Open Access
Wen Chen, Qianwen Ye,

Mingshuo Zhang

и другие.

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(5), С. 1856 - 1856

Опубликована: Фев. 21, 2025

Osteoarthritis (OA) is a common degenerative joint disease that progressively destroys articular cartilage, leading to increased friction and severe pain. Therefore, OA can be treated by restoring the lubricating properties of cartilage. In this study, recent advances in lubricants for treatment are reviewed both single-function multifunctional lubricants. Single-function mainly include glycosaminoglycans, lubricin, phospholipids, whereas composed anti-inflammatory bifunctional hydrogels, stem cell-loaded drug-loaded nanoparticles. This review emphasizes importance lubrication capacity explores structural features, properties, role these modulating intracellular inflammatory responses metabolism. Current challenges future research directions field also discussed, with aim providing scientific basis new ideas clinical OA.

Язык: Английский

Процитировано

0

Carboxybetaine modified chitosan as viscosupplementation for osteoarthritis therapy DOI
Tao Meng,

Zhengyu Zhao,

Mengge Song

и другие.

International Journal of Biological Macromolecules, Год журнала: 2025, Номер 307, С. 142155 - 142155

Опубликована: Март 15, 2025

Язык: Английский

Процитировано

0

Cartilage Lubrication from the Perspective of Wettability DOI

Xuhao Yang,

Feng Gao, Wenlong Song

и другие.

ACS Nano, Год журнала: 2025, Номер unknown

Опубликована: Апрель 2, 2025

Cartilage exhibits an extremely low friction and very wearability within the liquid environment of joint. It is also capable switching wettability between superhydrophilicity hydrophobicity in both wetting dry conditions (specific experimental operations or open wounds). Therefore, understanding cartilage lubrication from perspective provides inspiration for design artificial sections with motion soft actuators coefficients (COF). In this review, articular introduced discussed view wettability. First, basic principles are described a focus on compositions cartilage, particular relationship phospholipid layers supramolecular synergy synovial fluid cartilage. Subsequently, under different stimuli (such as shear, pH, temperature, electric field) insights into lubrication. Finally, we present comprehensive summary delineate challenges domain assisting researchers formulating viable concepts efficient substitution smart lubricating devices.

Язык: Английский

Процитировано

0

Flowing biomaterials—lubrication matrix DOI
Hui Yuan,

Wenguo Cui

Science Bulletin, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0

Recent Advances in Biomimetic Related Lubrication DOI Creative Commons

Jinqiang Shao,

Guiyao Lan,

Haoxin Song

и другие.

Lubricants, Год журнала: 2024, Номер 12(11), С. 377 - 377

Опубликована: Окт. 30, 2024

Friction is ubiquitous in industry and daily life, which not only leads to the wear tear of equipment machinery, but also causes a lot energy waste. one significant factors leading loss mechanical systems. Therefore, it essential minimize friction losses. Creatures nature have evolved various surfaces with different tribological characteristics adapt environment. By studying, understanding, summarizing lubrication regulation phenomena typical nature, bionic theories methods are obtained guide development new materials This article primarily discusses study mechanisms through biomimetic design, mainly divided into chemical approaches, structural strategies, chemical–structural coupling approaches. From point view, this paper summarizes joint engineering biomedicine, inspiration from lotus leaves, fish skin, snake each unique antifriction structures famous for their super hydrophobicity nature. Finally, simulates mechanism natural organisms action biological substances, applied coating so as reduce on surfaces, improve durability anti-pollution ability coatings, significantly performance systems, promote scientific innovation, conservation, emission reduction, sustainable development.

Язык: Английский

Процитировано

1

Biologically controllable adhesion interfaces DOI
Hui Yuan, Juan Wang, Wenguo Cui

и другие.

Science Bulletin, Год журнала: 2024, Номер unknown

Опубликована: Окт. 1, 2024

Язык: Английский

Процитировано

0

Nanozyme‐Engineered Hyaluronic Acid Adhesives Loading Platelet‐Rich Plasma for Multilayered Osteoarthritis Treatment with Pain‐Relief Effect DOI
Yiyang Zhao,

Wanglin Duan,

Bin Zhu

и другие.

Advanced Functional Materials, Год журнала: 2024, Номер unknown

Опубликована: Дек. 23, 2024

Abstract Osteoarthritis (OA) is the most common degenerative joint disease, causing pain, disability, and economic strain. Combining nanozymes with dopamine (DOPA)‐based adhesives offers a promising approach to effectively modulate microenvironment of OA‐affected tissues. However, traditional fabrication methods DOPA‐based often involve external oxidants or curing agents, which can introduce additional oxidative stress, posing systemic risks. Here, different enzyme‐catalyzed activities platinum–copper (PtCu) at pH values are utilized directly catalyze cross‐linking DOPA‐modified hyaluronic acid (HAD), representing new polymerization method for phenol‐based bioadhesives. The resulting adhesive (HAD/PtCu/platelet‐rich plasma (PRP)), when combined PRP, mitigates generation proinflammatory factors, scavenges reactive oxygen species, boosts hypoxic chemotaxis chondrocytes, stimulates chondrocyte proliferation migration, protects interleukin‐1β‐treated human articular C28/I2 cells from further OA advancement. Additionally, in vivo assessments show that HAD/PtCu/PRP significantly alleviates pain improves knee osteoarthritic rats. These findings suggest provides alternative therapy.

Язык: Английский

Процитировано

0