Role of Probiotics in Depression: Connecting Dots of Gut-Brain-Axis Through Hypothalamic-Pituitary Adrenal Axis and Tryptophan/Kynurenic Pathway involving Indoleamine-2,3-dioxygenase
Molecular Neurobiology,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 28, 2025
Язык: Английский
Neuroactive Kynurenines as Pharmacological Targets: New Experimental Tools and Exciting Therapeutic Opportunities
Pharmacological Reviews,
Год журнала:
2024,
Номер
76(6), С. 978 - 1008
Опубликована: Сен. 20, 2024
Both
preclinical
and
clinical
studies
implicate
functional
impairments
of
several
neuroactive
metabolites
the
kynurenine
pathway
(KP),
major
degradative
cascade
essential
amino
acid
tryptophan
in
mammals,
pathophysiology
neurologic
psychiatric
diseases.
A
number
KP
enzymes,
such
as
2,3-dioxygenase
(TDO2),
indoleamine
2,3-dioxygenases
(IDO1
IDO2),
aminotransferases
(KATs),
3-monooxygenase
(KMO),
3-hydroxyanthranilic
oxygenase
(3-HAO),
quinolinic
phosphoribosyltransferase
(QPRT),
control
brain
metabolism
health
disease
are
therefore
increasingly
considered
to
be
promising
targets
for
treatment
disorders
nervous
system.
Understanding
distribution,
cellular
expression,
regulation
enzymes
is
critical
conceptualization
implementation
successful
therapeutic
strategies.
SIGNIFICANCE
STATEMENT:
Studies
have
implicated
Key
regulate
both
disease,
making
them
treating
these
disorders.
Therefore,
understanding
developing
effective
This
review
endeavors
describe
processes
detail.
Язык: Английский
Psychedelics in neuroinflammation: Mechanisms and therapeutic potential
Progress in Neuro-Psychopharmacology and Biological Psychiatry,
Год журнала:
2025,
Номер
unknown, С. 111278 - 111278
Опубликована: Янв. 1, 2025
Язык: Английский
Kynurenine amplifies tetrahydrocannabinol-induced sensorimotor impairment and classic “tetrad” effects in mice
Progress in Neuro-Psychopharmacology and Biological Psychiatry,
Год журнала:
2025,
Номер
unknown, С. 111342 - 111342
Опубликована: Март 1, 2025
Язык: Английский
The compulsive eating paradigm: can psychedelics help in treating obesity?
Journal of Eating Disorders,
Год журнала:
2025,
Номер
13(1)
Опубликована: Апрель 7, 2025
Obesity
is
a
multifactorial
disorder
involving
behavioural
aetiology
in
subsets
of
patients
that
traditional
therapeutic
approaches
have
failed
to
address.
Drawing
parallels
with
addiction,
the
rewarding
aspects
chronic
energy-dense
diet
can
compromise
dopaminergic
reward
circuits,
eventually
causing
individuals
become
habitually
responsive
food-related
stimuli
despite
adverse
health
consequences.
The
maladaptive
prediction
and
motivational
salience
becomes
associated
exert
top-down
influence
on
perception
attention,
promoting
compulsive
eating
behaviour.
Emerging
research
suggests
psychedelics,
e.g.,
psilocybin
LSD,
induce
non-ordinary
mental
states
where
such
behaviours
could
potentially
be
reduced
modified.
Based
current
evidence,
mechanisms
been
proposed
which
suggest
psychedelics
might
relax
high-level
predictions
encoded
within
neuronal
hierarchies
sensitise
them
bottom-up
information
flow.
Additionally,
are
thought
open
window
psychological
flexibility,
allowing
people
new
cognitive
strategies
offered
via
assisted
psychotherapy.
Therefore,
psychedelics-assisted
psychotherapy
may
encourage
beneficial
changes
behaviour,
those
habits.
While
promising
theory,
needed
assess
potential
efficacy
treating
Язык: Английский
Computed Tomography and Fluorescence Spectroscopy Blood Plasma Analysis Study for Kynurenic Acid as a Diagnostic Approach to Chronic Coenurosis in Sheep
Life,
Год журнала:
2024,
Номер
14(9), С. 1121 - 1121
Опубликована: Сен. 5, 2024
Coenurosis
is
a
parasitic
disease
caused
by
the
larval
stage
of
Язык: Английский