Role of Probiotics in Depression: Connecting Dots of Gut-Brain-Axis Through Hypothalamic-Pituitary Adrenal Axis and Tryptophan/Kynurenic Pathway involving Indoleamine-2,3-dioxygenase

Molecular Neurobiology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 28, 2025

Language: Английский

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Neuroactive Kynurenines as Pharmacological Targets: New Experimental Tools and Exciting Therapeutic Opportunities

Pharmacological Reviews, Journal Year: 2024, Volume and Issue: 76(6), P. 978 - 1008

Published: Sept. 20, 2024

Both preclinical and clinical studies implicate functional impairments of several neuroactive metabolites the kynurenine pathway (KP), major degradative cascade essential amino acid tryptophan in mammals, pathophysiology neurologic psychiatric diseases. A number KP enzymes, such as 2,3-dioxygenase (TDO2), indoleamine 2,3-dioxygenases (IDO1 IDO2), aminotransferases (KATs), 3-monooxygenase (KMO), 3-hydroxyanthranilic oxygenase (3-HAO), quinolinic phosphoribosyltransferase (QPRT), control brain metabolism health disease are therefore increasingly considered to be promising targets for treatment disorders nervous system. Understanding distribution, cellular expression, regulation enzymes is critical conceptualization implementation successful therapeutic strategies. SIGNIFICANCE STATEMENT: Studies have implicated Key regulate both disease, making them treating these disorders. Therefore, understanding developing effective This review endeavors describe processes detail.

Language: Английский

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Psychedelics in neuroinflammation: Mechanisms and therapeutic potential

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Journal Year: 2025, Volume and Issue: unknown, P. 111278 - 111278

Published: Jan. 1, 2025

Language: Английский

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Kynurenine amplifies tetrahydrocannabinol-induced sensorimotor impairment and classic “tetrad” effects in mice

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Journal Year: 2025, Volume and Issue: unknown, P. 111342 - 111342

Published: March 1, 2025

Language: Английский

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The compulsive eating paradigm: can psychedelics help in treating obesity?

Journal of Eating Disorders, Journal Year: 2025, Volume and Issue: 13(1)

Published: April 7, 2025

Obesity is a multifactorial disorder involving behavioural aetiology in subsets of patients that traditional therapeutic approaches have failed to address. Drawing parallels with addiction, the rewarding aspects chronic energy-dense diet can compromise dopaminergic reward circuits, eventually causing individuals become habitually responsive food-related stimuli despite adverse health consequences. The maladaptive prediction and motivational salience becomes associated exert top-down influence on perception attention, promoting compulsive eating behaviour. Emerging research suggests psychedelics, e.g., psilocybin LSD, induce non-ordinary mental states where such behaviours could potentially be reduced modified. Based current evidence, mechanisms been proposed which suggest psychedelics might relax high-level predictions encoded within neuronal hierarchies sensitise them bottom-up information flow. Additionally, are thought open window psychological flexibility, allowing people new cognitive strategies offered via assisted psychotherapy. Therefore, psychedelics-assisted psychotherapy may encourage beneficial changes behaviour, those habits. While promising theory, needed assess potential efficacy treating

Language: Английский

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Computed Tomography and Fluorescence Spectroscopy Blood Plasma Analysis Study for Kynurenic Acid as a Diagnostic Approach to Chronic Coenurosis in Sheep

Life, Journal Year: 2024, Volume and Issue: 14(9), P. 1121 - 1121

Published: Sept. 5, 2024

Coenurosis is a parasitic disease caused by the larval stage of

Language: Английский

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