A comprehensive review of conventional and stimuli-responsive delivery systems for bioactive peptides: from food to biomedical applications
Advanced Composites and Hybrid Materials,
Год журнала:
2024,
Номер
8(1)
Опубликована: Ноя. 30, 2024
Язык: Английский
Recent Advances in Promoting Bone Regeneration in Type 2 Diabetes Using Drug Delivery Vehicles and Vehicle‐Free Therapeutics
Advanced Therapeutics,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 12, 2025
Abstract
The
incidence
of
type
2
diabetes
(T2DM)
increases
significantly
worldwide.
Due
to
consistent
hyperglycemia,
insulin
resistance,
and
chronic
inflammation,
T2DM
patients
encounter
osteoporosis
induced
osteoporotic
fracture
risks.
Antidiabetic
drugs
have
been
traditional
therapies
that
seek
control
blood
glucose,
balance
bone
metabolism,
favor
systemic
immunosuppression.
However,
such
impact
quality
its
nano‐scale
features
in
the
long‐term.
Today,
biomedical
experts
are
continuously
advancing
drug
delivery
tools
for
local
osteo‐immunomodulatory
agents
T2DM.
It
is
demonstrated
bioavailability
release
profile
determine
osteoconductivity
outcomes
therapeutics.
This
review
focuses
on
introducing
currently
used
vehicles
fabrication
techniques
biomaterial‐based
systems
thoroughly
examined.
Furthermore,
feasibility
potential
factors
contributing
bioactive
surveyed.
extent
vivo
responses
described
context
current
research
examples.
Targeted
signaling
mechanisms
also
assessed
detail
elucidate
activated
healing
routes.
Язык: Английский
Development of a thiol-maleimide crosslinked carboxymethyl guar gum hydrogel for sustained drug delivery
Journal of Drug Delivery Science and Technology,
Год журнала:
2025,
Номер
unknown, С. 106633 - 106633
Опубликована: Янв. 1, 2025
Язык: Английский
Additive manufacturing for biomedical bone implants: Shaping the future of bones
Materials Science and Engineering R Reports,
Год журнала:
2025,
Номер
163, С. 100931 - 100931
Опубликована: Янв. 30, 2025
Язык: Английский
Tailoring the dendronized structures of cyclodextrin-based supramolecular nanoassemblies for enhanced tumor paraptosis via disrupting endoplasmic reticulum homeostasis
Acta Biomaterialia,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 1, 2025
Язык: Английский
Synthesis of Functional Pectin‐Based Hydrogels via Thiol‐Maleimide Click Reaction for Enhanced Drug Encapsulation and Release
Journal of Applied Polymer Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 12, 2025
ABSTRACT
This
work
describes
the
synthesis
and
characterization
of
a
novel
hydrogel
system
based
on
pectin
(PT)
functionalized
with
thiol
maleimide
groups
cross‐linked
by
thiol‐maleimide
click
chemistry.
Thiolated
PT
(PT‐SH)
maleimide‐modified
(PT‐Ma)
precursors
were
synthesized
carbodiimide‐mediated
amidation
confirmed
elemental
analysis,
FTIR,
1H
NMR
spectroscopy.
The
resulting
exhibited
gelation
efficiency
over
80%,
swelling
degrees
ranging
from
44%
to
80%
depending
cross‐linking
density,
pH‐sensitive
behavior
maximum
at
pH
8.
demonstrated
high
mechanical
stability,
compressive
strengths
20.8–33.2
kPa,
increasing
density.
As
model
drug,
ibuprofen
was
encapsulated
efficiencies
up
337
mg/g
released
in
controlled
fashion.
In
vitro
release
studies
showed
slower
acidic
environments,
which
ranged
22%
53%
within
6–10
h,
faster
slightly
alkaline
environment,
consistent
profile
hydrogel.
Such
properties
underline
hydrogel's
potential
for
sustained
drug
delivery.
Pectin
hydrogels,
upon
cross‐linking,
are
hereby
presented
be
strong
platform
biomedical
applications
properties,
behavior,
performance
Язык: Английский
Recent applications of stimulus-responsive smart hydrogels for osteoarthritis therapy
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2025,
Номер
13
Опубликована: Фев. 17, 2025
Osteoarthritis
is
one
of
the
most
common
degenerative
joint
diseases,
which
seriously
affects
life
middle-aged
and
elderly
people.
Traditional
treatments
such
as
surgical
treatment
systemic
medication,
often
do
not
achieve
expected
or
optimal
results,
leads
to
severe
trauma
a
variety
side
effects.
Therefore,
there
an
urgent
need
develop
novel
therapeutic
options
overcome
these
problems.
Hydrogels
are
widely
used
in
biomedical
tissue
repairing
platform
for
loading
drugs,
proteins
stem
cells.
In
recent
years,
smart-responsive
hydrogels
have
achieved
excellent
results
drug
delivery
systems
osteoarthritis.
This
review
focuses
on
advances
endogenous
stimuli
(including
enzymes,
pH,
reactive
oxygen
species
temperature,
etc.)
responsive
exogenous
light,
shear,
ultrasound
magnetism,
osteoarthritis
treatment.
Finally,
current
limitations
application
future
prospects
smart
summarized.
Язык: Английский