Recent applications of stimulus-responsive smart hydrogels for osteoarthritis therapy DOI Creative Commons
Zhuoming Xu, Jintao Liu,

Hanyin Hu

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 13

Published: Feb. 17, 2025

Osteoarthritis is one of the most common degenerative joint diseases, which seriously affects life middle-aged and elderly people. Traditional treatments such as surgical treatment systemic medication, often do not achieve expected or optimal results, leads to severe trauma a variety side effects. Therefore, there an urgent need develop novel therapeutic options overcome these problems. Hydrogels are widely used in biomedical tissue repairing platform for loading drugs, proteins stem cells. In recent years, smart-responsive hydrogels have achieved excellent results drug delivery systems osteoarthritis. This review focuses on advances endogenous stimuli (including enzymes, pH, reactive oxygen species temperature, etc.) responsive exogenous light, shear, ultrasound magnetism, osteoarthritis treatment. Finally, current limitations application future prospects smart summarized.

Language: Английский

A comprehensive review of conventional and stimuli-responsive delivery systems for bioactive peptides: from food to biomedical applications DOI
Shuang Wang, Xinhao Wang, Yangchao Luo

et al.

Advanced Composites and Hybrid Materials, Journal Year: 2024, Volume and Issue: 8(1)

Published: Nov. 30, 2024

Language: Английский

Citations

10
Recent Advances in Promoting Bone Regeneration in Type 2 Diabetes Using Drug Delivery Vehicles and Vehicle‐Free Therapeutics DOI Open Access

Yasamin Pesaran Afsharian,

Mostafa Rahimnejad,

Sayed Mahmood Rabiee

et al.

Advanced Therapeutics, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 12, 2025

Abstract The incidence of type 2 diabetes (T2DM) increases significantly worldwide. Due to consistent hyperglycemia, insulin resistance, and chronic inflammation, T2DM patients encounter osteoporosis induced osteoporotic fracture risks. Antidiabetic drugs have been traditional therapies that seek control blood glucose, balance bone metabolism, favor systemic immunosuppression. However, such impact quality its nano‐scale features in the long‐term. Today, biomedical experts are continuously advancing drug delivery tools for local osteo‐immunomodulatory agents T2DM. It is demonstrated bioavailability release profile determine osteoconductivity outcomes therapeutics. This review focuses on introducing currently used vehicles fabrication techniques biomaterial‐based systems thoroughly examined. Furthermore, feasibility potential factors contributing bioactive surveyed. extent vivo responses described context current research examples. Targeted signaling mechanisms also assessed detail elucidate activated healing routes.

Language: Английский

Citations

0
Development of a thiol-maleimide crosslinked carboxymethyl guar gum hydrogel for sustained drug delivery DOI
Rua B. Alnoman, Hussam Y. Alharbi,

Majed S. Aljohani

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106633 - 106633

Published: Jan. 1, 2025

Language: Английский

Citations

0
Additive manufacturing for biomedical bone implants: Shaping the future of bones DOI Creative Commons

Muhammad Hassan Razzaq,

Usama Zaheer, Humayun Asghar

et al.

Materials Science and Engineering R Reports, Journal Year: 2025, Volume and Issue: 163, P. 100931 - 100931

Published: Jan. 30, 2025

Language: Английский

Citations

0
Tailoring the dendronized structures of cyclodextrin-based supramolecular nanoassemblies for enhanced tumor paraptosis via disrupting endoplasmic reticulum homeostasis DOI
Jiecheng Ji, Jie Zhou, Xue Li

et al.

Acta Biomaterialia, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

0
Synthesis of Functional Pectin‐Based Hydrogels via Thiol‐Maleimide Click Reaction for Enhanced Drug Encapsulation and Release DOI Open Access
Hussam Y. Alharbi, Rua B. Alnoman,

Majed S. Aljohani

et al.

Journal of Applied Polymer Science, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 12, 2025

ABSTRACT This work describes the synthesis and characterization of a novel hydrogel system based on pectin (PT) functionalized with thiol maleimide groups cross‐linked by thiol‐maleimide click chemistry. Thiolated PT (PT‐SH) maleimide‐modified (PT‐Ma) precursors were synthesized carbodiimide‐mediated amidation confirmed elemental analysis, FTIR, 1H NMR spectroscopy. The resulting exhibited gelation efficiency over 80%, swelling degrees ranging from 44% to 80% depending cross‐linking density, pH‐sensitive behavior maximum at pH 8. demonstrated high mechanical stability, compressive strengths 20.8–33.2 kPa, increasing density. As model drug, ibuprofen was encapsulated efficiencies up 337 mg/g released in controlled fashion. In vitro release studies showed slower acidic environments, which ranged 22% 53% within 6–10 h, faster slightly alkaline environment, consistent profile hydrogel. Such properties underline hydrogel's potential for sustained drug delivery. Pectin hydrogels, upon cross‐linking, are hereby presented be strong platform biomedical applications properties, behavior, performance

Language: Английский

Citations

0
Recent applications of stimulus-responsive smart hydrogels for osteoarthritis therapy DOI Creative Commons
Zhuoming Xu, Jintao Liu,

Hanyin Hu

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 13

Published: Feb. 17, 2025

Osteoarthritis is one of the most common degenerative joint diseases, which seriously affects life middle-aged and elderly people. Traditional treatments such as surgical treatment systemic medication, often do not achieve expected or optimal results, leads to severe trauma a variety side effects. Therefore, there an urgent need develop novel therapeutic options overcome these problems. Hydrogels are widely used in biomedical tissue repairing platform for loading drugs, proteins stem cells. In recent years, smart-responsive hydrogels have achieved excellent results drug delivery systems osteoarthritis. This review focuses on advances endogenous stimuli (including enzymes, pH, reactive oxygen species temperature, etc.) responsive exogenous light, shear, ultrasound magnetism, osteoarthritis treatment. Finally, current limitations application future prospects smart summarized.

Language: Английский

Citations

0