Phytotherapy Products and Active Principles

Опубликована: Янв. 1, 2025

Язык: Английский

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The pathophysiological signaling and efficacy of medicinal herbal compounds in Alzheimer’s disease

Deleted Journal, Год журнала: 2025, Номер 29(1), С. 3 - 24

Опубликована: Март 1, 2025

Язык: Английский

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Gathering scientific evidence for a new bioactive natural ingredient: The combination between chemical profiles and biological activities of Flueggea virosa extracts

Food Bioscience, Год журнала: 2022, Номер 49, С. 101967 - 101967

Опубликована: Авг. 14, 2022

Язык: Английский

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Revisiting the Mitochondrial Function and Communication in Neurodegenerative Diseases

Current Pharmaceutical Design, Год журнала: 2024, Номер 30(12), С. 902 - 911

Опубликована: Март 14, 2024

Neurodegenerative disorders are distinguished by the progressive loss of anatomically or physiologically relevant neural systems. Atypical mitochondrial morphology and metabolic malfunction found in many neurodegenerative disorders. Alteration function can occur as a result aberrant DNA, altered nuclear enzymes that interact with mitochondria actively passively, due to unexplained reasons. Mitochondria intimately linked Endoplasmic reticulum (ER), ER-mitochondrial communication governs several physiological functions procedures disrupted Numerous researchers have associated these interaction disturbance. In addition, DNA mutation increased ROS production resulting ionic imbalance leading functional structural alterations brain well cellular damage may an essential role disease progression via malfunction. this review, we explored evidence highlighting pathways most serious ailments, including Alzheimer's (AD), Parkinson's (PD), Huntington's (HD).

Язык: Английский

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Promising Strategies to Reduce the SARS-CoV-2 Amyloid Deposition in the Brain and Prevent COVID-19-Exacerbated Dementia and Alzheimer’s Disease

Pharmaceuticals, Год журнала: 2024, Номер 17(6), С. 788 - 788

Опубликована: Июнь 16, 2024

The COVID-19 pandemic, caused by infection with the SARS-CoV-2 virus, is associated cognitive impairment and Alzheimer’s disease (AD) progression. Once it enters brain, virus stimulates accumulation of amyloids in brain that are highly toxic to neural cells. These may trigger neurological symptoms COVID-19. meningeal lymphatic vessels (MLVs) play an important role removal toxins mediate viral drainage from brain. MLVs considered a promising target prevent COVID-19-exacerbated dementia. However, there limited methods for augmentation MLV function. This review highlights new discoveries field COVID-19-mediated amyloid development strategies stimulate clearance through other pathways. based on innovative treating dysfunction induced infection, including use photobiomodulation, plasmalogens, medicinal herbs, which offer hope addressing challenges posed virus.

Язык: Английский

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Unraveling the nexus of age, epilepsy, and mitochondria: exploring the dynamics of cellular energy and excitability

Frontiers in Pharmacology, Год журнала: 2024, Номер 15

Опубликована: Сен. 5, 2024

Epilepsy, a complex neurological condition marked by recurring seizures, is increasingly recognized for its intricate relationship with mitochondria, the cellular powerhouses responsible energy production and calcium regulation. This review offers an in-depth examination of interplay between epilepsy, mitochondrial function, aging. Many factors might account correlation epilepsy Mitochondria, integral to dynamics neuronal excitability, perform critical role in pathophysiology epilepsy. The mechanisms linking mitochondria are multifaceted, involving dysfunction, reactive oxygen species (ROS), dynamics. Mitochondrial dysfunction can trigger seizures compromising ATP production, increasing glutamate release, altering ion channel function. ROS, natural byproducts respiration, contribute oxidative stress neuroinflammation, epileptogenesis. govern fusion fission processes, influence seizure threshold buffering, impact propagation. Energy demands during highlight generation maintaining membrane potential. handling dynamically modulates affecting synaptic transmission action potential generation. Dysregulated hallmark contributing excitotoxicity. Epigenetic modifications function through histone modifications, DNA methylation, non-coding RNA expression. Potential therapeutic avenues targeting include mitochondria-targeted antioxidants, ketogenic diets, metabolic therapies. concludes outlining future directions research, emphasizing integrative approaches, advancements ethical considerations. Mitochondria emerge as central players narrative offering profound insights this challenging disorder.

Язык: Английский

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Anti-cholinesterase, anti-inflammatory and antioxidant properties of Combretum micranthum G. Don: Potential implications in neurodegenerative disease

IBRO Neuroscience Reports, Год журнала: 2022, Номер 14, С. 21 - 27

Опубликована: Дек. 8, 2022

Brain damage is a severe and common pathology that leads to life-threatening diseases. Despite development in the research, medical evidence of effectiveness potential neuroprotective medicines insufficient. As result, there an immense urgent demand for promising medication. For millennia, herbal remedies were fundamental aspect treatments. Combretum micranthum (CM), plant family Combretaceae sub-Saharan Africa, has been utilized folklore medicine cure diverse human ailments. In order develop phytomedicine, current research was undertaken explore antioxidant, anti-inflammatory, anticholinesterase CM extract.Colorimetric methods used determine antioxidant activity, in-vitro protein denaturation membrane destabilization assays evaluate its anti-inflammatory capacity, activity carried out using Ellman's method, assessed on brain homogenate stressed with ferric chloride ascorbic acid (FeCl2-AA) by assessing lipoperoxidation biomarker malondialdehyde (MDA).In Ferric Reducing Antioxidant Power (IC50 = 27.15 ± 0.06 µg/mL) Total Capacity 31.13 0.02 µg/mL), extract demonstrated strong activity. Anti-inflammatory effect improved heat-induced Egg albumin BSA (IC 50 46.35 1.53 23.94 1.10 as well heat hypotonia induced 20.96 0.11 16.75 0.94 µg/mL).CM showed 59.85 0.91 µg/mL). ex-vivo model, substantial inhibition (p < 0.001) oxidative caused FeCl2-AA tissue.C. may be good candidate probable potential. Its benefits might attributed effects.

Язык: Английский

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Phytochemical Profiling, Antioxidant and Cognitive-Enhancing Effect of Helichrysum italicum ssp. italicum (Roth) G. Don (Asteraceae)

Plants, Год журнала: 2023, Номер 12(15), С. 2755 - 2755

Опубликована: Июль 25, 2023

This study aimed at the evaluation of antioxidant and cognitive-enhancing effect methanol-aqueous extract from Helichrysum italicum ssp. aerial parts. Significant radical scavenging activity (110.33 ± 3.47 234.70 5.21 mg TE/g for DPPH ABTS) reducing power (354.23 17.51 210.24 8.68 CUPRAC FRAP) were observed. The showed average acetylcholinesterase low butyrylcholinesterase inhibitory potential. H. (200 mg/kg/po) administered in combination with galantamine (3 12 days significantly improved memory learning process compared alone passive avoidance test. was comparable to that Ginkgo biloba (100 mg/kg/po). In deep secondary metabolite annotation by UHPLC-HRMS, more than 90 hydroxybenzoic hydroxicinnamic acid-glycosides, phenylethanoid glycosides, a series acylquinic caffeoylhexaric acids, methoxylated derivatives scutellarein, quercetagetin 6-hydroxyluteolin, prenylated phloroglucinol-α-pyrones reported first time italicum. Fragmentation patterns four subclasses heterodimer-pyrones proposed. In-depth profiling pyrones revealed 23 compounds undescribed literature. Pyrones acylphloroglucinols together acids could account improvement. presented research advanced our knowledge italicum, highlighting species as rich source metabolites

Язык: Английский

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Dietary Supplements and Phytopharmaceuticals for the Management of Cognitive Disorders

Опубликована: Янв. 1, 2024

Язык: Английский

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In vitro antioxidant and enzyme inhibitory studies, computational analysis and chemodiversity of an emergency food plant Caralluma edulis (Edgew.) Benth. ex Hook.f: A multifunctional approach to provide new ingredients for nutraceuticals and functional foods

Food Bioscience, Год журнала: 2022, Номер 50, С. 102097 - 102097

Опубликована: Окт. 14, 2022

Язык: Английский

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