Cell Biochemistry and Function,
Год журнала:
2024,
Номер
42(8)
Опубликована: Дек. 1, 2024
ABSTRACT
Combination
therapy
offers
a
promising
advantage
because
they
target
multiple
pathways
involved
in
the
pathogenesis
and
progression
of
Alzheimer's
disease.
This
study
aimed
to
investigate
synergistic
effect
donepezil
each
vitamin
B12,
B6
B1
on
aluminium
chloride
(AlCl
3
)‐induced
neurotoxicity
rats.
Fifty‐four
rats
were
divided
into
nine
groups
six.
Group
I
received
distilled
water,
group
II—AlCl
(100
mg/kg),
III‐
AlCl
mg/kg)
+
Donepezil
(10
IV‐AlCl
Vitamin
B12
(5
V‐AlCl
VI‐AlCl
VII‐AlCl
VIII‐AlCl
IX‐AlCl
mg/kg).
Treatment
lasted
for
40
days.
Biochemical
analyses
brain
revealed
that
chronic
administration
significantly
increased
level
inflammatory
cytokines,
caspase
9,
malondialdehyde,
nitric
oxide
acetylcholinesterase
(AChE)
activity,
while
causing
significant
decrease
superoxide
dismutase
(SOD)
Nrf2,
reduced
glutathione,
dopamine
norepinephrine.
Results
also
showed
caused
cognitive
impairment
as
indicated
by
reduction
percentage
alternation
index
hypo‐activity
towards
novel
object
animals
treated
with
only.
Moreover,
results
from
biochemical
evaluations
treatment
donepezil,
B
vitamins
combination
attenuated
deficits
dopamine,
norepinephrine,
SOD
reducing
elevated
levels
oxide,
AChE,
9
markers.
These
observations
corroborated
result
histopathological
evaluation.
The
proved
be
more
effective
than
monotherapy.
conferred
protection
against
–induced
neurotoxicity,
however,
performed
better
neuroprotective
indices
was
amongst
three
therapies
this
study.
Biology Medicine & Natural Product Chemistry,
Год журнала:
2024,
Номер
13(1), С. 7 - 33
Опубликована: Май 2, 2024
Alzheimer's
disease
currently
affects
more
than
35
million
individuals
worldwide.
Aluminium
has
been
implicated
in
the
pathogenesis
of
various
cognitive
disorders.
Meanwhile,
aluminium
chloride
(AlCl3)
a
significant
impact
on
progression
neurodegenerative
diseases
including
disease.
The
majority
medications
now
market
are
cholinesterase
inhibitors.
However,
effectiveness
these
drugs
is
limited
because
they
can't
totally
arrest
utilization
medicinal
plants
and
natural
products
may
present
excellent
prospective
options
for
prevention
therapy.
This
study
summarized
treatment
AlCl3-induced
Alzheimer’s
as
an
alternative
therapy
using
published
data
literature
from
years
2021-2023.
help
to
reduce
by
controlling
different
pathways
could
be
used
therapeutic
agent
against
symptoms.
discussed
this
review
have
shown
neuroprotective,
antioxidant,
anti-amyloid,
anti-inflammatory,
anticholinesterase,
anti-apoptotic,
actions.
Therefore,
offer
neuroprotective
effects
Cellular and Molecular Neurobiology,
Год журнала:
2024,
Номер
44(1)
Опубликована: Окт. 16, 2024
Aging,
an
inevitable
physiological
process
leading
to
a
progressive
decline
in
bodily
functions,
has
been
abundantly
researched
domain
with
studies
attempting
slow
it
down
and
reduce
its
debilitating
effects.
Investigations
into
the
cellular
molecular
pathways
associated
aging
have
allowed
formulation
of
therapeutic
strategies.
Of
these,
caloric
restriction
(CR)
implicated
for
role
promoting
healthy
by
modulating
key
targets
like
Insulin/IGF-1,
mTOR,
sirtuins.
However,
CR
requires
dedication
commitment
strict
regimen
which
poses
difficulty
maintaining
consistency.
To
maneuver
around
cumbersome
diets,
Caloric
Restriction
Mimetics
(CRMs)
emerged
as
promising
alternatives
mimicking
beneficial
effects
CR.
This
review
elucidates
foundations
enabling
CRMs
rapamycin,
metformin,
resveratrol,
spermidine,
many
more
function
suitable
anti-aging
molecules.
Moreover,
explores
clinical
trials
(retrieved
from
clinicaltrials.gov
database)
aimed
at
demonstrating
efficacy
effective
candidates
against
age-related
neurodegenerative
diseases
such
Alzheimer's
disease
Parkinson's
disease.
Toxics,
Год журнала:
2023,
Номер
11(6), С. 509 - 509
Опубликована: Июнь 6, 2023
Jambolan
fruit
extract
and
choline
were
investigated
for
Aluminum
tri
chloride
(AlCl3)-induced
Alzheimer's
disease
in
rats.
Thirty-six
male
"Sprague
Dawley"
rats
weighing
(150
±
10
g)
allocated
into
six
groups;
the
first
group
was
fed
a
baseline
diet
served
as
negative
control.
(AD)
induced
Group
2
by
oral
administration
of
AlCl3
(17
mg/kg
body
weight)
dissolved
distilled
water
(served
positive
control).
Rats
3
orally
supplemented
concomitantly
with
both
500
BW
an
ethanolic
jambolan
once
daily
28
days
weight).
4:
Rivastigmine
(RIVA)
aqueous
infusion
(0.3
BW/day)
given
to
reference
drug
supplementation
days.
5
treated
(1.1
g/kg)
6
1.1
g/kg
test
additive
effects
concurrently
bw)
Body
weight
gain,
feed
intake,
efficiency
ratio,
relative
brain,
liver,
kidney,
spleen
calculated
after
trial.
Brain
tissue
assessment
analyzed
antioxidant/oxidant
markers,
biochemical
analysis
blood
serum,
phenolic
compound
fruits
extracted
high-performance
liquid
chromatography
(HPLC),
histopathology
brain.
The
results
showed
that
improved
brain
functions,
histopathology,
antioxidant
enzyme
activity
compared
group.
In
conclusion,
administering
can
lower
toxic
impacts
aluminum
on
Phytomedicine Plus,
Год журнала:
2023,
Номер
3(4), С. 100492 - 100492
Опубликована: Окт. 10, 2023
Gallic
acid
(GA)
is
a
polyphenolic
substance
which
can
be
sourced
naturally
from
plant
sources
and
also
synthesized
industrially.
In-depth
study
on
GA
in
recent
years
has
revealed
that
it
powerful
anti-inflammatory
antioxidant
properties.
In
many
disease
models,
been
found
to
ameliorate
oxidative
stress,
inflammation
resultant
damage.
The
neuroprotective
properties
of
against
numerous
animal
models
neurodegenerative
disorders
have
outlined
by
number
vivo
investigations.
However,
this
present
review
dedicated
towards
providing
comprehensive
information
the
bioavailability,
effects
underlying
mechanism
activity
for
management
disorders.
demonstratively
was
highlighted
as
backbone
its
effect.
It
safe
conclude
antioxidant,
anti-inflammatory,
metal
chelating
proved
beneficial
diseases,
hence
use
should
recommended
single
therapy
or
combination
with
currently
approved
drugs
these
diseases.
Current Issues in Molecular Biology,
Год журнала:
2023,
Номер
45(6), С. 4908 - 4922
Опубликована: Июнь 5, 2023
Colorectal
cancer
(CRC)
is
the
third
most
common
with
a
high
mortality
rate
worldwide.
Although
gallic
acid
and
hesperidin
exert
anticancer
activity,
synergistic
effects
of
against
CRC
remain
elusive.
This
study
aims
to
investigate
therapeutic
mechanism
novel
combination
cell
growth,
including
viability,
cell-cycle-associated
proteins,
spheroid
formation,
stemness.Gallic
derived
from
Hakka
pomelo
tea
(HPT)
were
detected
by
colorimetric
methods
high-performance
liquid
chromatography
using
ethyl
acetate
as
an
extraction
medium.
lines
(HT-29
HCT-116)
treated
combined
extract
investigated
in
our
for
viability
(trypan
blue
or
soft
agar
colony
formation
assay),
cycle
(propidium
iodide
staining),
proteins
(immunoblotting),
stem
markers
(immunohistochemistry
staining).Compared
other
methods,
HPT
medium
exerts
potent
effect
on
inhibiting
HT-29
growth
dose-dependent
manner.
Furthermore,
treatment
had
higher
inhibitory
than
alone.
The
underlying
was
involved
G1-phase
arrest
Cip1/p21
upregulation
that
could
attenuate
HCT-116
proliferation
(Ki-67),
stemness
(CD-133),
3D
assay
mimicking
vivo
tumorigenesis.Gallic
spheroids,
may
serve
potential
chemopreventive
agent.
Further
testing
safety
effectiveness
large-scale
randomized
trials
required.
Naunyn-Schmiedeberg s Archives of Pharmacology,
Год журнала:
2023,
Номер
397(5), С. 3493 - 3512
Опубликована: Ноя. 15, 2023
Abstract
Di-(2-ethylhexyl)
phthalate
(DEHP)
is
the
most
abundant
threatening
public
health-induced
neurotoxicity.
This
neurotoxicity
associated
with
behavioral
and
biochemical
deficits
in
male
rats.
Our
study
investigated
neuroprotective
effect
of
ferulic
acid
(FA)
on
rats
exposed
to
DEHP.
Thirty-two
Wistar
were
assigned
four
groups.
Group
I
control
received
corn
oil,
group
II
intoxicated
300
mg/kg
DEHP,
III
DEHP
+
50
FA,
IV
all
agents
administrated
daily
per
os
for
30
days.
Anxiety-like
behavior,
spatial
working
memory,
recognition
memory
assessed.
Also,
brain
oxidative
stress
biomarkers,
including
malondialdehyde
(MDA),
reduced
glutathione
(GSH),
nitric
oxide
(NO),
superoxide
dismutase
(SOD),
brain-derived
neurotrophic
factor
(BDNF)
as
well
heme
oxygenase-1
(HO-1)
measured.
Moreover,
histopathology
examinations
immunohistochemistry
determination
caspase-3
also
evaluated.
Furthermore,
docking
simulation
was
adapted
understand
inhibitory
role
FA
NO
synthase.
Compared
DEHP-intoxicated
rats,
FA-treated
displayed
improved
cognitive
a
anxious
state.
redox
state
maintained
increased
BNDF
levels.
These
changes
confirmed
by
restoring
normal
architecture
tissue
decrement
caspase-3.
In
conclusion,
has
potent
antioxidant
antiapoptotic
properties
that
confirm
activity
possible
prospect
its
therapeutic
capabilities
nutritional
supplement
value.
CNS & Neurological Disorders - Drug Targets,
Год журнала:
2023,
Номер
23(10), С. 1234 - 1250
Опубликована: Ноя. 29, 2023
Abstract:
Neurodegenerative
conditions
like
Alzheimer's
disease
(AD),
Parkinson's
(PD),
and
amyotrophic
lateral
sclerosis
(ALS)
encompass
disorders
characterized
by
the
degeneration
of
neurons
in
specific
circumstances.
The
quest
for
novel
agents
to
influence
these
diseases,
particularly
AD,
has
unearthed
various
natural
compounds
displaying
multifaceted
activities
diverse
pharmacological
mechanisms.
Given
ongoing
extensive
study
pathways
associated
with
accumulation
neurofibrillary
aggregates
amyloid
plaques,
this
paper
aims
comprehensively
review
around
130
studies
exploring
products.
These
focus
on
inhibiting
formation
plaques
tau
protein
tangles,
objective
potentially
alleviating
or
delaying
AD.
Current Behavioral Neuroscience Reports,
Год журнала:
2024,
Номер
11(4), С. 246 - 259
Опубликована: Авг. 27, 2024
Abstract
Purpose
of
Review
Experimental
evidence
suggests
that
flavonoids
prevent
neurodegeneration
and
improves
cognitive
function.
In
this
study,
we
systematically
reviewed
the
effect
hesperidin
on
deficits
neurobehavioural
outcomes
in
vivo
studies.
Recent
Findings:
A
systematic
search
PubMed,
EBSCOhost,
Web
Science,
Scopus
ProQuest
was
conducted.
Meta-analysis
performed
parameters
(Morris
Water
Maze,
Y-Maze,
elevated
plus
maze,
rotarod
test,
locomotion
activity,
passive
avoidance
open
field
test
forced
swimming
test).
The
mixed
model
used
to
compute
standard
mean
difference
(SMD).
total
1069
documents
were
retrieved.
However,
46
studies
included
review
meta-analysis.
Our
findings
revealed
did
not
significantly
affect
performance
normal
rats
compared
with
placebo.
Moreover,
improved
memory
learning,
sensorimotor
function
activity
impaired
rats.
Hesperidin
show
any
significant
anxiety-related
diseased
model.
Summary:
neurocognitive
effects
could
be
associated
its
neuroprotective
against
neuroinflammation,
oxidative
stress-induced
neuronal
damage,
inhibition
cholinergic
deficit
mitochondrial
dysfunction.
These
results
correlate
available
scientific
dysfunction
cognitive-impaired
Cell Biochemistry and Function,
Год журнала:
2024,
Номер
42(8)
Опубликована: Дек. 1, 2024
ABSTRACT
Combination
therapy
offers
a
promising
advantage
because
they
target
multiple
pathways
involved
in
the
pathogenesis
and
progression
of
Alzheimer's
disease.
This
study
aimed
to
investigate
synergistic
effect
donepezil
each
vitamin
B12,
B6
B1
on
aluminium
chloride
(AlCl
3
)‐induced
neurotoxicity
rats.
Fifty‐four
rats
were
divided
into
nine
groups
six.
Group
I
received
distilled
water,
group
II—AlCl
(100
mg/kg),
III‐
AlCl
mg/kg)
+
Donepezil
(10
IV‐AlCl
Vitamin
B12
(5
V‐AlCl
VI‐AlCl
VII‐AlCl
VIII‐AlCl
IX‐AlCl
mg/kg).
Treatment
lasted
for
40
days.
Biochemical
analyses
brain
revealed
that
chronic
administration
significantly
increased
level
inflammatory
cytokines,
caspase
9,
malondialdehyde,
nitric
oxide
acetylcholinesterase
(AChE)
activity,
while
causing
significant
decrease
superoxide
dismutase
(SOD)
Nrf2,
reduced
glutathione,
dopamine
norepinephrine.
Results
also
showed
caused
cognitive
impairment
as
indicated
by
reduction
percentage
alternation
index
hypo‐activity
towards
novel
object
animals
treated
with
only.
Moreover,
results
from
biochemical
evaluations
treatment
donepezil,
B
vitamins
combination
attenuated
deficits
dopamine,
norepinephrine,
SOD
reducing
elevated
levels
oxide,
AChE,
9
markers.
These
observations
corroborated
result
histopathological
evaluation.
The
proved
be
more
effective
than
monotherapy.
conferred
protection
against
–induced
neurotoxicity,
however,
performed
better
neuroprotective
indices
was
amongst
three
therapies
this
study.
