Unravelling hierarchical patterning of biomaterial inks with 3D microfluidic-assisted spinning: a paradigm shift in bioprinting technologies DOI Creative Commons
Sajad Mohammadi, Gianluca Cidonio

Frontiers in Biomaterials Science, Год журнала: 2023, Номер 2

Опубликована: Окт. 17, 2023

For decades, 3D bioprinting has offered a revolutionising approach to combine living cells and biomaterials engineer complex, yet functional constructs. However, traditional platforms fall short of the ability pattern complex gradients biomaterials, cells, ultimately bio-physical properties drive tissue formation regeneration. Recently, microfluidic-assisted (3DMB) risen as new hybrid for fabrication physiologically relevant tissues, adopting microfluidic chip printhead achieve hierarchical patterning bioinks precise control over microscale architecture printed constructs, enabling creation multi-layered tissues. This review explores recent advancements in graded biomaterial using spinning novel technologies. The physiological arrangement human tissues crucial role achieving ordered assembly is hereby discussed. Lastly, integration techniques with highlighted, examining latest regeneration disease modelling.

Язык: Английский

Conducting Polymer Nanoparticles with Intrinsic Aqueous Dispersibility for Conductive Hydrogels DOI Creative Commons
Joshua Tropp, Caralyn P. Collins, Xinran Xie

и другие.

Advanced Materials, Год журнала: 2023, Номер 36(1)

Опубликована: Сен. 8, 2023

Abstract Conductive hydrogels are promising materials with mixed ionic‐electronic conduction to interface living tissue (ionic signal transmission) medical devices (electronic transmission). The hydrogel form factor also uniquely bridges the wet/soft biological environment dry/hard of electronics. synthesis for bioelectronics requires scalable, biocompatible fillers high electronic conductivity and compatibility common aqueous formulations/resins. Despite significant advances in processing carbon nanomaterials, that satisfy all these requirements lacking. Herein, intrinsically dispersible acid‐crystalized PEDOT:PSS nanoparticles (ncrys‐PEDOT X ) reported which processed through a facile scalable nonsolvent induced phase separation method from commercial without complex instrumentation. particles feature conductivities up 410 S cm −1 , when compared other conductive fillers, display remarkable dispersibility, enabling homogeneous incorporation at relatively loadings within diverse biomaterial solutions additives or surfactants. dispersibility ncrys‐PEDOT allows simple into resins designed microstereolithography sonication surfactant optimization; biomedical structures fine features (< 150 µm) printed 10% particle loading . overcome challenges traditional providing biocompatible, plug‐and‐play platform soft organic bioelectronic materials.

Язык: Английский

Процитировано

48

CQDs-Cross-Linked Conductive Collagen/PAA-Based Nanocomposite Organohydrogel Coupling Flexibility with Multifunctionality for Dual-Modal Sensing of Human Motions DOI

Maohua Lan,

Jinwei Zhang, Jin Zhou

и другие.

ACS Applied Materials & Interfaces, Год журнала: 2024, Номер unknown

Опубликована: Апрель 27, 2024

Conductive hydrogels are ideal materials for intelligent medical devices, human-machine interfaces, and flexible bioelectrodes due to their adjustable mechanical properties electrical responsiveness, whereas it is still a great challenge achieve the integration of excellent flexibility biocompatibility into one hydrogel sensor while also incorporating self-healing, self-adhesion, environmental tolerance, antimicrobial properties. Here, nanocomposite conductive organohydrogel was constructed by using collagen (Col), alginate-derived carbon quantum dots (OSA-CQDs), poly(acrylic acid) (PAA), ethylene glycol reduced AgNPs, Fe3+ ions. Depending on OSA-CQDs with multiple chemical binding sites high specific surface area as cross-linkers, coupling highly biologically active Col chains PAA serving an energy dissipation module, resulting exhibited (795% strain, 193 kPa strength), cell compatibility (>95% survival rate), self-healing efficiency (HE = 79.5%), antifreezing (−20 °C), moisturizing (>120 h), repeatable adhesion (strength >20 kPa, times >10), inhibitory activity against Escherichia coli Staphylococcus aureus (9 21.5 cm2), conductivity, strain sensitivity (σ 1.34 S/m, gauge factor (GF) 11.63). Based all-in-one multifunction, can collaboratively adapt multimode sensing electrophysiological realize wireless real-time monitoring human activities physiological health. Therefore, this work provides new common platform design next-generation hydrogel-based smart wearable sensors.

Язык: Английский

Процитировано

38

Inversely engineered biomimetic flexible network scaffolds for soft tissue regeneration DOI Creative Commons
Shunze Cao, Yu Wei, Renheng Bo

и другие.

Science Advances, Год журнала: 2023, Номер 9(39)

Опубликована: Сен. 27, 2023

Graft-host mechanical mismatch has been a longstanding issue in clinical applications of synthetic scaffolds for soft tissue regeneration. Although numerous efforts have devoted to resolve this grand challenge, the regenerative performance existing remains limited by slow growth (comparing autograft) and failures. We demonstrate class rationally designed flexible network that can precisely replicate nonlinear responses tissues enhance regeneration via reduced graft-host mismatch. Such scaffold includes tubular frame containing inversely engineered curved microstructures produce desired properties, with an electrospun ultrathin film wrapped around offer proper microenvironment cell growth. Using rat models sciatic nerve defects or Achilles tendon injuries, our show performances evidently superior clinically approved conduit achieve similar outcomes autologous transplantation prevention target organ atrophy recovery static index.

Язык: Английский

Процитировано

30

Phosphorus-containing aromatic polymers: Synthesis, structure, properties and membrane-based applications DOI
Arijit Ghorai, Susanta Banerjee

Progress in Polymer Science, Год журнала: 2023, Номер 138, С. 101646 - 101646

Опубликована: Янв. 14, 2023

Язык: Английский

Процитировано

29

Developing conductive hydrogels for biomedical applications DOI Creative Commons
Yu Wang, Jiahui Guo, Xinyue Cao

и другие.

Smart Medicine, Год журнала: 2023, Номер 3(1)

Опубликована: Сен. 15, 2023

Conductive hydrogels have attracted copious attention owing to their grateful performances, such as similarity biological tissues, compliance, conductivity and biocompatibility. A diversity of conductive been developed showed versatile potentials in biomedical applications. In this review, we highlight the recent advances hydrogels, involving various types functionalities well applications fields. Furthermore, current challenges reasonable outlook are also given. It is expected that review will provide potential guidance for advancement next-generation hydrogels.

Язык: Английский

Процитировано

27

Electroactive biomaterials synergizing with electrostimulation for cardiac tissue regeneration and function-monitoring DOI Creative Commons
Yanping Zhang,

Alice Le Friec,

Zhongyang Zhang

и другие.

Materials Today, Год журнала: 2023, Номер 70, С. 237 - 272

Опубликована: Сен. 30, 2023

Cardiac cells are assembled within a complicated microenvironment possessing diverse biochemical and biophysical cues that modulate cellular behaviors tissue functions. Apart from the widely studied pathways of regulation, positive effects electrical on regeneration excitable cardiac tissues have been demonstrated. Conductive biomaterials emerged as important two-way media to facilitate transmission endogenous bioelectricity or exogenous stimuli strengthening regeneration, while in meantime allow online monitoring bioelectrical activities. Mechanical energy exists prevalently heart, which brings huge promise building self-powered, enabled, on-demand stimulation system by using piezoelectric biomaterials. In this regard, conductive synergizing with electrostimulation for function-monitoring engineering comprehensively reviewed. After biological conduction human heart is firstly introduced, electroactive display biomimetic microenvironmental (e.g., electrical, mechanical, topological) their mediated summarized. Subsequently, current state systematically overviewed together underlying mechanisms modulating cell Furthermore, recent advances used function discussed. Finally, remaining challenges 3D complex designs, systematic parameter optimizations mechanisms, long-term performance, biosafety laid out, call interdisplinary joint forces innovation advancement.

Язык: Английский

Процитировано

24

Recent Progress in Implantable Drug Delivery Systems DOI

Guangqin He,

Haimei Li, Junyi Liu

и другие.

Advanced Materials, Год журнала: 2024, Номер 36(23)

Опубликована: Фев. 20, 2024

Abstract In recent years, tremendous effort is devoted to developing platforms, such as implantable drug delivery systems (IDDSs), with temporally and spatially controlled release capabilities improved adherence. IDDSs have multiple advantages: i) the timing location of can be by patients using specific stimuli (light, sound, electricity, magnetism, etc.). Some intelligent “closed‐loop” IDDS even realize self‐management without human participation. ii) enable continuous stable drugs over a long period (months years) iii) administer directly lesion, thereby helping reduce dosage side effects. iv) personalized according patient needs. The high demand for has prompted scientists make efforts develop IDDS. this review, several common stimulus‐responsive mechanisms including endogenous (e.g., pH, reactive oxygen species, proteins, etc.) exogenous light, etc.), are given in detail. Besides, types reported years reviewed, various based on above mechanisms, radio frequency‐controlled IDDS, self‐powered etc. Finally, advantages disadvantages bottleneck problems, possible solutions analyzed provide directions subsequent research.

Язык: Английский

Процитировано

11

Cell-free biodegradable electroactive scaffold for urinary bladder tissue regeneration DOI Creative Commons
Rebecca L. Keate, Matthew I. Bury,

Maria Mendez-Santos

и другие.

Nature Communications, Год журнала: 2025, Номер 16(1)

Опубликована: Янв. 2, 2025

Tissue engineering heavily relies on cell-seeded scaffolds to support the complex biological and mechanical requirements of a target organ. However, in addition safety efficacy, translation tissue technology will depend manufacturability, affordability, ease adoption. Therefore, there is need develop scalable biomaterial with sufficient bioactivity eliminate for exogenous cell seeding. Herein, we describe implementation an electroactive biodegradable elastomer urinary bladder engineering. To create electrically conductive mechanically robust scaffold regeneration, functionalization method wherein hydrophobic polymer poly(3,4-ethylenedioxythiophene) (PEDOT) polymerized situ within similarly citrate-based poly(octamethylene-citrate-co-octanol) (POCO) film. We demonstrate efficacy this augmentation primarily female athymic rats, comparing PEDOT-POCO mesenchymal stromal POCO scaffolds. recovers function anatomical structure comparably significantly better than non-cell-seeded This manuscript reports that confers electroactivity elastic scaffold, facilitating successful restoration physiological Cell seeding regenerative presents regulatory manufacturing hurdle. Here, authors report development free which can regeneration without seeding, demonstrating application repair.

Язык: Английский

Процитировано

1

Neuroregulation during Bone Formation and Regeneration: Mechanisms and Strategies DOI

Xiangrong Zhao,

Meilin Yao, Yuyi Wang

и другие.

ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown

Опубликована: Янв. 27, 2025

The skeleton is highly innervated by numerous nerve fibers. These fibers, in addition to transmitting information within the bone and mediating sensations, play a crucial role regulating tissue formation regeneration. Traditional engineering (BTE) often fails achieve satisfactory outcomes when dealing with large-scale defects, which frequently related lack of effective reconstruction neurovascular network. In recent years, increasing research has revealed critical nerves metabolism. Nerve fibers regulate cells through neurotransmitters, neuropeptides, peripheral glial cells. Furthermore, also coordinate vascular immune systems jointly construct microenvironment favorable for As signaling driver formation, neuroregulation spans entire process physiological activities from embryonic postmaturity remodeling repair. However, there currently comprehensive summaries these regulatory mechanisms. Therefore, this review sketches out function during Then, we elaborate on mechanisms coupling neuromodulation immunity. Finally, discuss several novel strategies neuro-bone (NBTE) based bone, focusing coordinated regeneration tissue.

Язык: Английский

Процитировано

1

Recent advances and innovations in the design and fabrication of wearable flexible biosensors and human health monitoring systems based on conjugated polymers DOI
Vinh Van Tran, Viet‐Duc Phung, Daeho Lee

и другие.

Bio-Design and Manufacturing, Год журнала: 2024, Номер 7(4), С. 476 - 516

Опубликована: Июль 1, 2024

Язык: Английский

Процитировано

7