Frontiers in Biomaterials Science,
Journal Year:
2023,
Volume and Issue:
2
Published: Oct. 17, 2023
For
decades,
3D
bioprinting
has
offered
a
revolutionising
approach
to
combine
living
cells
and
biomaterials
engineer
complex,
yet
functional
constructs.
However,
traditional
platforms
fall
short
of
the
ability
pattern
complex
gradients
biomaterials,
cells,
ultimately
bio-physical
properties
drive
tissue
formation
regeneration.
Recently,
microfluidic-assisted
(3DMB)
risen
as
new
hybrid
for
fabrication
physiologically
relevant
tissues,
adopting
microfluidic
chip
printhead
achieve
hierarchical
patterning
bioinks
precise
control
over
microscale
architecture
printed
constructs,
enabling
creation
multi-layered
tissues.
This
review
explores
recent
advancements
in
graded
biomaterial
using
spinning
novel
technologies.
The
physiological
arrangement
human
tissues
crucial
role
achieving
ordered
assembly
is
hereby
discussed.
Lastly,
integration
techniques
with
highlighted,
examining
latest
regeneration
disease
modelling.
Advanced Materials,
Journal Year:
2023,
Volume and Issue:
36(1)
Published: Sept. 8, 2023
Abstract
Conductive
hydrogels
are
promising
materials
with
mixed
ionic‐electronic
conduction
to
interface
living
tissue
(ionic
signal
transmission)
medical
devices
(electronic
transmission).
The
hydrogel
form
factor
also
uniquely
bridges
the
wet/soft
biological
environment
dry/hard
of
electronics.
synthesis
for
bioelectronics
requires
scalable,
biocompatible
fillers
high
electronic
conductivity
and
compatibility
common
aqueous
formulations/resins.
Despite
significant
advances
in
processing
carbon
nanomaterials,
that
satisfy
all
these
requirements
lacking.
Herein,
intrinsically
dispersible
acid‐crystalized
PEDOT:PSS
nanoparticles
(ncrys‐PEDOT
X
)
reported
which
processed
through
a
facile
scalable
nonsolvent
induced
phase
separation
method
from
commercial
without
complex
instrumentation.
particles
feature
conductivities
up
410
S
cm
−1
,
when
compared
other
conductive
fillers,
display
remarkable
dispersibility,
enabling
homogeneous
incorporation
at
relatively
loadings
within
diverse
biomaterial
solutions
additives
or
surfactants.
dispersibility
ncrys‐PEDOT
allows
simple
into
resins
designed
microstereolithography
sonication
surfactant
optimization;
biomedical
structures
fine
features
(<
150
µm)
printed
10%
particle
loading
.
overcome
challenges
traditional
providing
biocompatible,
plug‐and‐play
platform
soft
organic
bioelectronic
materials.
Conductive
hydrogels
are
ideal
materials
for
intelligent
medical
devices,
human-machine
interfaces,
and
flexible
bioelectrodes
due
to
their
adjustable
mechanical
properties
electrical
responsiveness,
whereas
it
is
still
a
great
challenge
achieve
the
integration
of
excellent
flexibility
biocompatibility
into
one
hydrogel
sensor
while
also
incorporating
self-healing,
self-adhesion,
environmental
tolerance,
antimicrobial
properties.
Here,
nanocomposite
conductive
organohydrogel
was
constructed
by
using
collagen
(Col),
alginate-derived
carbon
quantum
dots
(OSA-CQDs),
poly(acrylic
acid)
(PAA),
ethylene
glycol
reduced
AgNPs,
Fe3+
ions.
Depending
on
OSA-CQDs
with
multiple
chemical
binding
sites
high
specific
surface
area
as
cross-linkers,
coupling
highly
biologically
active
Col
chains
PAA
serving
an
energy
dissipation
module,
resulting
exhibited
(795%
strain,
193
kPa
strength),
cell
compatibility
(>95%
survival
rate),
self-healing
efficiency
(HE
=
79.5%),
antifreezing
(−20
°C),
moisturizing
(>120
h),
repeatable
adhesion
(strength
>20
kPa,
times
>10),
inhibitory
activity
against
Escherichia
coli
Staphylococcus
aureus
(9
21.5
cm2),
conductivity,
strain
sensitivity
(σ
1.34
S/m,
gauge
factor
(GF)
11.63).
Based
all-in-one
multifunction,
can
collaboratively
adapt
multimode
sensing
electrophysiological
realize
wireless
real-time
monitoring
human
activities
physiological
health.
Therefore,
this
work
provides
new
common
platform
design
next-generation
hydrogel-based
smart
wearable
sensors.
Science Advances,
Journal Year:
2023,
Volume and Issue:
9(39)
Published: Sept. 27, 2023
Graft-host
mechanical
mismatch
has
been
a
longstanding
issue
in
clinical
applications
of
synthetic
scaffolds
for
soft
tissue
regeneration.
Although
numerous
efforts
have
devoted
to
resolve
this
grand
challenge,
the
regenerative
performance
existing
remains
limited
by
slow
growth
(comparing
autograft)
and
failures.
We
demonstrate
class
rationally
designed
flexible
network
that
can
precisely
replicate
nonlinear
responses
tissues
enhance
regeneration
via
reduced
graft-host
mismatch.
Such
scaffold
includes
tubular
frame
containing
inversely
engineered
curved
microstructures
produce
desired
properties,
with
an
electrospun
ultrathin
film
wrapped
around
offer
proper
microenvironment
cell
growth.
Using
rat
models
sciatic
nerve
defects
or
Achilles
tendon
injuries,
our
show
performances
evidently
superior
clinically
approved
conduit
achieve
similar
outcomes
autologous
transplantation
prevention
target
organ
atrophy
recovery
static
index.
Smart Medicine,
Journal Year:
2023,
Volume and Issue:
3(1)
Published: Sept. 15, 2023
Conductive
hydrogels
have
attracted
copious
attention
owing
to
their
grateful
performances,
such
as
similarity
biological
tissues,
compliance,
conductivity
and
biocompatibility.
A
diversity
of
conductive
been
developed
showed
versatile
potentials
in
biomedical
applications.
In
this
review,
we
highlight
the
recent
advances
hydrogels,
involving
various
types
functionalities
well
applications
fields.
Furthermore,
current
challenges
reasonable
outlook
are
also
given.
It
is
expected
that
review
will
provide
potential
guidance
for
advancement
next-generation
hydrogels.
Materials Today,
Journal Year:
2023,
Volume and Issue:
70, P. 237 - 272
Published: Sept. 30, 2023
Cardiac
cells
are
assembled
within
a
complicated
microenvironment
possessing
diverse
biochemical
and
biophysical
cues
that
modulate
cellular
behaviors
tissue
functions.
Apart
from
the
widely
studied
pathways
of
regulation,
positive
effects
electrical
on
regeneration
excitable
cardiac
tissues
have
been
demonstrated.
Conductive
biomaterials
emerged
as
important
two-way
media
to
facilitate
transmission
endogenous
bioelectricity
or
exogenous
stimuli
strengthening
regeneration,
while
in
meantime
allow
online
monitoring
bioelectrical
activities.
Mechanical
energy
exists
prevalently
heart,
which
brings
huge
promise
building
self-powered,
enabled,
on-demand
stimulation
system
by
using
piezoelectric
biomaterials.
In
this
regard,
conductive
synergizing
with
electrostimulation
for
function-monitoring
engineering
comprehensively
reviewed.
After
biological
conduction
human
heart
is
firstly
introduced,
electroactive
display
biomimetic
microenvironmental
(e.g.,
electrical,
mechanical,
topological)
their
mediated
summarized.
Subsequently,
current
state
systematically
overviewed
together
underlying
mechanisms
modulating
cell
Furthermore,
recent
advances
used
function
discussed.
Finally,
remaining
challenges
3D
complex
designs,
systematic
parameter
optimizations
mechanisms,
long-term
performance,
biosafety
laid
out,
call
interdisplinary
joint
forces
innovation
advancement.
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(23)
Published: Feb. 20, 2024
Abstract
In
recent
years,
tremendous
effort
is
devoted
to
developing
platforms,
such
as
implantable
drug
delivery
systems
(IDDSs),
with
temporally
and
spatially
controlled
release
capabilities
improved
adherence.
IDDSs
have
multiple
advantages:
i)
the
timing
location
of
can
be
by
patients
using
specific
stimuli
(light,
sound,
electricity,
magnetism,
etc.).
Some
intelligent
“closed‐loop”
IDDS
even
realize
self‐management
without
human
participation.
ii)
enable
continuous
stable
drugs
over
a
long
period
(months
years)
iii)
administer
directly
lesion,
thereby
helping
reduce
dosage
side
effects.
iv)
personalized
according
patient
needs.
The
high
demand
for
has
prompted
scientists
make
efforts
develop
IDDS.
this
review,
several
common
stimulus‐responsive
mechanisms
including
endogenous
(e.g.,
pH,
reactive
oxygen
species,
proteins,
etc.)
exogenous
light,
etc.),
are
given
in
detail.
Besides,
types
reported
years
reviewed,
various
based
on
above
mechanisms,
radio
frequency‐controlled
IDDS,
self‐powered
etc.
Finally,
advantages
disadvantages
bottleneck
problems,
possible
solutions
analyzed
provide
directions
subsequent
research.
Nature Communications,
Journal Year:
2025,
Volume and Issue:
16(1)
Published: Jan. 2, 2025
Tissue
engineering
heavily
relies
on
cell-seeded
scaffolds
to
support
the
complex
biological
and
mechanical
requirements
of
a
target
organ.
However,
in
addition
safety
efficacy,
translation
tissue
technology
will
depend
manufacturability,
affordability,
ease
adoption.
Therefore,
there
is
need
develop
scalable
biomaterial
with
sufficient
bioactivity
eliminate
for
exogenous
cell
seeding.
Herein,
we
describe
implementation
an
electroactive
biodegradable
elastomer
urinary
bladder
engineering.
To
create
electrically
conductive
mechanically
robust
scaffold
regeneration,
functionalization
method
wherein
hydrophobic
polymer
poly(3,4-ethylenedioxythiophene)
(PEDOT)
polymerized
situ
within
similarly
citrate-based
poly(octamethylene-citrate-co-octanol)
(POCO)
film.
We
demonstrate
efficacy
this
augmentation
primarily
female
athymic
rats,
comparing
PEDOT-POCO
mesenchymal
stromal
POCO
scaffolds.
recovers
function
anatomical
structure
comparably
significantly
better
than
non-cell-seeded
This
manuscript
reports
that
confers
electroactivity
elastic
scaffold,
facilitating
successful
restoration
physiological
Cell
seeding
regenerative
presents
regulatory
manufacturing
hurdle.
Here,
authors
report
development
free
which
can
regeneration
without
seeding,
demonstrating
application
repair.
The
skeleton
is
highly
innervated
by
numerous
nerve
fibers.
These
fibers,
in
addition
to
transmitting
information
within
the
bone
and
mediating
sensations,
play
a
crucial
role
regulating
tissue
formation
regeneration.
Traditional
engineering
(BTE)
often
fails
achieve
satisfactory
outcomes
when
dealing
with
large-scale
defects,
which
frequently
related
lack
of
effective
reconstruction
neurovascular
network.
In
recent
years,
increasing
research
has
revealed
critical
nerves
metabolism.
Nerve
fibers
regulate
cells
through
neurotransmitters,
neuropeptides,
peripheral
glial
cells.
Furthermore,
also
coordinate
vascular
immune
systems
jointly
construct
microenvironment
favorable
for
As
signaling
driver
formation,
neuroregulation
spans
entire
process
physiological
activities
from
embryonic
postmaturity
remodeling
repair.
However,
there
currently
comprehensive
summaries
these
regulatory
mechanisms.
Therefore,
this
review
sketches
out
function
during
Then,
we
elaborate
on
mechanisms
coupling
neuromodulation
immunity.
Finally,
discuss
several
novel
strategies
neuro-bone
(NBTE)
based
bone,
focusing
coordinated
regeneration
tissue.
