Frontiers in Biomaterials Science,
Год журнала:
2023,
Номер
2
Опубликована: Окт. 17, 2023
For
decades,
3D
bioprinting
has
offered
a
revolutionising
approach
to
combine
living
cells
and
biomaterials
engineer
complex,
yet
functional
constructs.
However,
traditional
platforms
fall
short
of
the
ability
pattern
complex
gradients
biomaterials,
cells,
ultimately
bio-physical
properties
drive
tissue
formation
regeneration.
Recently,
microfluidic-assisted
(3DMB)
risen
as
new
hybrid
for
fabrication
physiologically
relevant
tissues,
adopting
microfluidic
chip
printhead
achieve
hierarchical
patterning
bioinks
precise
control
over
microscale
architecture
printed
constructs,
enabling
creation
multi-layered
tissues.
This
review
explores
recent
advancements
in
graded
biomaterial
using
spinning
novel
technologies.
The
physiological
arrangement
human
tissues
crucial
role
achieving
ordered
assembly
is
hereby
discussed.
Lastly,
integration
techniques
with
highlighted,
examining
latest
regeneration
disease
modelling.
Journal of Biomaterials Applications,
Год журнала:
2024,
Номер
39(5), С. 409 - 420
Опубликована: Авг. 17, 2024
Piezoelectric
ceramics
are
piezoelectric
materials
with
polycrystalline
structure
and
have
been
widely
used
in
many
fields
such
as
medical
imaging
sound
sensors.
As
knowledge
about
this
kind
of
material
develops,
researchers
find
possess
favorable
piezoelectricity,
biocompatibility,
mechanical
properties,
porous
antibacterial
effect
endeavor
to
apply
the
field
bone
tissue
engineering.
However,
clinically
no
exercised
so
far.
Therefore,
paper
we
present
a
comprehensive
review
research
development
various
including
barium
titanate,
potassium
sodium
niobate
zinc
oxide
aims
explore
application
regeneration
by
providing
detailed
overview
current
regeneration.
Tissue
damage
often
causes
considerable
suffering
to
patients
due
slow
recovery
and
poor
prognosis.
The
use
of
electroactive
materials
deliver
biophysical
signals
plays
a
key
role
in
regulating
tissue
regeneration
processes.
Among
these
materials,
piezoelectric
have
unique
electromechanical
conversion
capabilities,
making
them
suitable
for
as
cell
scaffolds.
They
can
deform
emit
electrical
response
external
stimuli,
thereby
proliferation
differentiation.
In
this
review,
recent
advances
are
presented
physical
signaling
mediators
that
regulate
basic
mechanisms,
classification
their
different
applications
described.
Finally,
comprehensive
discussion
current
challenges
prospects
the
field
is
provided.
Together,
existing
experimental
results
basically
show
improve
process
effect
repair,
providing
new
technical
options
development
engineering
future.
Macromolecular Materials and Engineering,
Год журнала:
2023,
Номер
309(1)
Опубликована: Сен. 22, 2023
Abstract
Heart
patches
are
currently
being
utilized
to
repair
damaged
myocardium
and
a
promising
way
address
the
limitations
of
current
therapeutic
strategies.
Given
electromechanical
nature
cardiac
tissue,
conductive
or
piezoelectric
materials
interest
researchers.
An
electrospinning
method
is
used
synthesize
evaluate
polyvinylidene
fluoride/graphene
oxide
(PVDF/GO)
nanocomposites.
Effects
GO
concentration
(0,
0.1,
0.3,
0.5,
0.7,
1
wt%)
on
main
physical‐mechanical
characteristics
patch
studied.
Results
show
nanofibers
containing
0.7
wt%
with
diameter
857
±
168
nm,
provide
excellent
tensile
strength
(0.51
10.34
MPa).
Fourier
transform
infrared
X‐ray
diffraction
analysis
confirm
increase
β‐polymer
phase
by
adding
from
63%
86%.
However,
highest
output
voltage
in
shock
test
recorded
at
9.44
V
for
0.5
wt%,
which
increased
8.2
times
compared
neat
PVDF.
In
addition,
human
umbilical
vein
endothelial
cell
culture
electrospun
confirmed
no
toxicity
as
well
growth
proliferation
(3.4
times)
over
7
d.
The
developed
material
has
potential
be
heart
due
its
characteristics.
Advanced Materials,
Год журнала:
2024,
Номер
36(35)
Опубликована: Июнь 11, 2024
Medical
patches
have
garnered
increasing
attention
in
recent
decades
for
several
diagnostic
and
therapeutic
applications.
Advancements
material
science,
manufacturing
technologies,
bioengineering
significantly
widened
their
functionalities,
rendering
them
highly
versatile
platforms
wearable
implantable
Of
particular
interest
are
triggerable
designed
drug
delivery
tissue
regeneration
purposes,
whose
action
can
be
controlled
by
an
external
signal.
Stimuli-responsive
particularly
appealing
as
they
may
enable
a
high
level
of
temporal
spatial
control
over
the
therapy,
allowing
precision
possibility
to
adjust
treatment
according
specific
clinical
personal
needs.
This
review
aims
provide
comprehensive
overview
existing
extensive
literature
on
patches,
emphasizing
potential
diverse
applications
highlighting
strengths
weaknesses
different
triggering
stimuli.
Additionally,
current
open
challenges
related
design
use
efficient
such
tuning
mechanical
adhesive
properties,
ensuring
acceptable
trade-off
between
smartness
biocompatibility,
endowing
with
portability
autonomy,
accurately
controlling
responsiveness
stimulus
maximizing
efficacy,
reviewed.
ACS Applied Materials & Interfaces,
Год журнала:
2024,
Номер
16(30), С. 38852 - 38879
Опубликована: Июль 23, 2024
Biophysical
and
clinical
medical
studies
have
confirmed
that
biological
tissue
lesions
trauma
are
related
to
the
damage
of
an
intrinsic
electret
(i.e.,
endogenous
electric
field),
such
as
wound
healing,
embryonic
development,
occurrence
various
diseases,
immune
regulation,
regeneration,
cancer
metastasis.
As
exogenous
electrical
signals,
conductivity,
piezoelectricity,
ferroelectricity,
pyroelectricity,
bioelectroactives
can
regulate
field,
thus
controlling
function
cells
promoting
repair
regeneration
tissues.
Materials,
once
polarized,
harness
their
inherent
polarized
static
fields
generate
field
through
direct
stimulation
or
indirect
interactions
facilitated
by
physical
friction,
ultrasound,
mechanical
stimulation.
The
interaction
with
microenvironment
allows
for
regulation
compensation
signals
in
damaged
microenvironments,
leading
repair.
technique
shows
great
promise
applications
regeneration.
In
this
paper,
generation
change
electroactive
substances
expounded,
latest
research
progress
its
effects
include
bone
repair,
nerve
drug
penetration
promotion,
etc.
Finally,
opportunities
challenges
materials
were
summarized.
Exploring
development
new
mechanism
regulating
changes
may
provide
insights
innovative
methods
disease
treatment
applications.
Macromolecular Bioscience,
Год журнала:
2022,
Номер
23(3)
Опубликована: Дек. 22, 2022
Abstract
Microfibers,
a
type
of
long,
thin,
and
flexible
material,
can
be
assembled
into
functional
3D
structures
by
folding,
binding,
weaving.
As
novel
spinning
method,
combining
microfluidic
technology
wet
spinning,
precisely
control
the
size,
morphology,
structure,
composition
microfibers.
Particularly,
process
is
mild
rapid,
which
suitable
for
preparing
microfibers
using
biocompatible
materials
without
affecting
viability
cells
encapsulated.
Furthermore,
owing
to
controllability
with
well‐defined
(such
as
hollow
structures)
will
contribute
exchange
nutrients
or
guide
cell
orientation.
Thus,
this
method
often
used
fabricate
scaffolds
encapsulation
adhesion
further
applied
biomimetic
fibrous
tissues.
In
review,
focus
on
different
fiber
prepared
technology,
including
solid,
hollow,
heterogeneous
structures,
generated
from
three
essential
elements:
platform,
composition,
solidification
methods.
application
described
in
tissue
engineering,
such
blood
vessels,
skeletal
muscle,
bone,
nerves,
lung
bronchi.
Finally,
challenges
future
development
prospects
engineering
applications
are
discussed.
Advanced Materials Technologies,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 4, 2025
Abstract
3D
printing
is
a
leading
technique
for
fabricating
tissue
engineering
scaffolds
that
facilitate
native
cellular
behavior.
Engineering
to
possess
functional
properties
like
electronic
conductivity
the
first
step
toward
integrating
new
technological
capabilities
stimulating
or
monitoring
activity
beyond
traditionally
presented
biophysical
and
biochemical
cues.
However,
these
bioelectronic
have
been
largely
underdeveloped
since
majority
of
electrically
conducting
materials
high
stiffness
values
outside
physiological
range
may
negatively
impact
desired
cell
Here,
methods
poly(3,4‐ethylenedioxythiophene):poly(styrene
sulfonate)
(PEDOT:PSS)
hydrogel
techniques
achieve
relevant
many
soft
tissues
(<100
kPa)
are
reported.
Structures
confirmed
as
ideal
by
maintaining
biostability,
promoting
viability,
well
appropriate
morphology
proliferation.
These
findings
present
customizable
platform
provides
favorable
microenvironments
this
envisioned
be
adaptable
several
applications.
Advanced Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 20, 2025
Stereolithography
bioprinting
relies
heavily
on
costly
photoinitiators
for
polymerization,
limiting
its
potential
further
technical
advancement
to
meet
growing
needs
in
tissue
engineering
and
regenerative
medicine.
Thermal
initiators,
contrast,
are
low
cost,
rapid
growth
of
the
photothermal
conversion
field
offers
a
wide
range
materials
tools
convert
light
into
heat.
However,
high-resolution
stereolithography
remains
unattainable
due
difficulty
confining
heat
an
aqueous
environment.
Here,
this
challenge
has
been
fully
addressed
by
establishing
imaging-guided
microscale
(ImPSB).
This
technique
is
achieved
through
building
novel
system
that
provides
depth-resolved
visualization
printing
dynamics,
creating
unique
initiator
second
near-infrared
window,
developing
new
bioink
seeing
controlling
gelation
process.
ImPSB
achieves
resolution
≈47
µm
generates
smooth
lines
arbitrarily
designed
shapes
with
cross-sectional
diameter
as
small
≈104
µm,
representing
unprecedented
scale
from
stereolithography.
Its
cellular
biocompatibility
both
bioscaffold
cell-laden
hydrogel
demonstrated,
feasibility
transdermal
also
shown.
work
sets
path
where
vast
resources
can
be
utilized.
