Carbohydrate Polymers, Год журнала: 2024, Номер 343, С. 122461 - 122461
Опубликована: Июль 3, 2024
This study reports a pH/magnetic dual-responsive hemicellulose-based nanocomposite hydrogel with nearly 100 % carbohydrate polymer-based and biodegradable polymer compositions for drug delivery. We synthesized pure Fe
Язык: Английский
Процитировано
12
ACS Applied Engineering Materials, Год журнала: 2024, Номер unknown
Опубликована: Янв. 31, 2024
Constitutionally isomeric peptides are a class of molecules with the same composition but different connections, ultimately exhibiting significant variation in properties. In this review, we survey recent advances rational design constitutionally and preparation discrete assemblies. Then, examine their applications as templates for inorganic nanoparticle growth, biofilm elimination, or carriers on-demand gas/drug delivery. At end, both future outlooks upcoming challenges emerging research topic also discussed. It is our hope that review will give insight into how subtle modulation peptide sequence would generate dramatic change resultant property.
Язык: Английский
Процитировано
10
Advanced Functional Materials, Год журнала: 2024, Номер 34(37)
Опубликована: Май 15, 2024
Abstract Carrier‐free nanodrugs that integrate chemodrugs and other therapeutic agents demonstrate good efficacy minimized side effects, showing promise for combined therapy. However, a key challenge lies in enhancing the bioavailability potential of through controllable assembly process. Herein, carrier‐free photothermal nanodrug (ZPQ NPs) is constructed flavonol‐driven with amine‐substituted perylene diimide enhanced chemo‐photothermal cancer The flavonol, particularly quercetin, facilitates J‐aggregation derivatives within contributes to multiple improvements, including red‐shifted absorption, fluorescence intensity, improved conversion efficiency as well excellent photostability. Moreover, also demonstrates cellular uptake intracellular reactive oxygen species scavenging capability. combination quercetin effect effectively kills cells, alleviates inflammation following Guided by vivo imaging, application ZPQ NPs results complete tumor elimination inhibits recurrence This work presents straightforward strategy constructing exhibit simultaneous enhancements both photophysical properties biological activity.
Язык: Английский
Процитировано
9
Current Opinion in Solid State and Materials Science, Год журнала: 2025, Номер 34, С. 101212 - 101212
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
1
Advanced Materials, Год журнала: 2025, Номер unknown
Опубликована: Апрель 7, 2025
Abstract Precise cancer nanomedicine requires rational molecular instructions of therapeutic agents. Harnessing the structure‐property‐function relationships represents a practical strategy toward smart and effective nanomedicine. A structurally novel hydrogen‐bonded (H‐bonded) supramolecular nanoformulation generated by orthogonal self‐sorting assembly chemo‐prodrug (FPtF) phototherapeutics (BPeB) is here reported, to reach an autonomous with improved anti‐tumor efficacy combining chemo/phototherapy (CT/PT). The high‐fidelity H‐bonding modularity from privileged heterocomplementary diaminopyridine/5‐fluorouracil (DAP/FU) Hamilton wedge/barbiturate (HW/Ba) pairs, respectively enable precise spatial control binding interactions FPtF BPeB, in turn allowing process specific “mix‐and‐match” capability. To directly stimulate phototherapy BPeB via near‐infrared (NIR) light, spectral matched upconversion nanoparticles (UCNPs, β‐NaYF 4 :Yb,Er) are encapsulated simultaneously. As result, polymeric nanomicelles, i.e., F/B/U@PHDO, readily fabricated. Moreover, distinct association constant (Ka) DAP/FU (≈10 2 M −1 ) HW/Ba 4‐5 pairs reflect different strengths stabilities H‐bonds, thus endowing programmable dissociation, accompanied release through pH/thermal‐stimuli. Therapeutic regime appreciated outcomes ultimately accomplished combined CT/PT. opportunities offered design anticipated point new paradigm for therapy.
Язык: Английский
Процитировано
1
Journal of Controlled Release, Год журнала: 2025, Номер 379, С. 609 - 620
Опубликована: Янв. 24, 2025
Язык: Английский
Процитировано
0
Chemistry - A European Journal, Год журнала: 2025, Номер unknown
Опубликована: Фев. 17, 2025
Abstract Supramolecular polymers are constructed through highly reversible and directionally specific non‐covalent interactions between monomer units. This unique feature enables supramolecular to undergo controlled structural reconfiguration functional transformation in response external stimuli, imparting them with high environmental responsiveness self‐healing properties. In particular, exhibit several advantages compared conventional polymers, such as inherent degradability, the ease of preparation incorporation units, smart various biological stimuli. These characters make promising candidates for intelligent drug delivery systems complex environments. this review, we comprehensively summarize latest developments representative achievements fields, focusing primarily on design synthesis, properties functionalities, practical applications small molecule delivery, gene therapy, protein delivery. Finally, highlight future research directions, multifunctionality, adaptability, personalized therapy. We focus recent studies that address key challenges field, providing rational polymer design, important properties, functionality, understanding strategies. expected advance new platforms systems, offering innovative solutions treatment diseases.
Язык: Английский
Процитировано
0
Опубликована: Март 29, 2025
Язык: Английский
Процитировано
0
Macromolecular Bioscience, Год журнала: 2025, Номер unknown
Опубликована: Апрель 22, 2025
Abstract In addition to the 20 standard amino acids that form building blocks of proteins, nature employs alternative create specialized “noncanonical peptides.” These unique peptides, found in organisms from bacteria humans, often exhibit unconventional structures and functionalities, playing critical roles modulating cellular processes, particularly as antibiotics. Their potential has attracted significant interest for designing novel functional materials based on noncanonical peptides. This review highlights recent advances generation application peptide assemblies. It begins with a definition including classic examples showcase their distinct useful biological activities. Then applications assemblies developing anticancer therapeutics are discussed, focusing representative studies demonstrate efficacy versatility targeting tumor cells. Beyond oncology, it is explored how have been utilized biomaterials, regenerative medicine, molecular imaging catalysis. Finally, perspectives offered future directions this rapidly evolving field, emphasizing exciting opportunities remaining challenges will drive continued innovation applying peptide‐based
Язык: Английский
Процитировано
0
Journal of the American Chemical Society, Год журнала: 2025, Номер unknown
Опубликована: Май 15, 2025
The chemical conjugation of poly(ethylene glycol) (PEG) to therapeutic agents, known as PEGylation, is a well-established strategy for enhancing drug solubility, stability, and pharmacokinetics. Here, we report on class supramolecular polymeric prodrugs by utilizing oligo(ethylene (OEG) modify the hydrophobic anticancer camptothecin (CPT). These OEGylated prodrugs, despite their low molecular weight, spontaneously self-assemble into polymers (SPs) with tubular morphology, featuring dense OEG coating surface. By designing biodegradable linkers varying stabilities, investigated how release kinetics CPT influence in vitro vivo performance these SPs. Our findings demonstrate that self-assembling (SAPDs) self-immolative disulfanyl-ethyl carbonate (etcSS) linker exhibit faster rate than those reducible disulfanyl butyrate (buSS) linker, leading higher potency significantly improved antitumor efficacy. Notably, two stable SPs, Tubustecan (TT) 1E TT 7E, outperformed irinotecan─a clinically approved prodrug─in colon cancer model, achieving enhanced tumor growth inhibition prolonged animal survival. results highlight potential OEGylation an important engineering drug-based underscore critical role stability vs optimizing prodrug design.
Язык: Английский
Процитировано
0