ACS Applied Engineering Materials, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 31, 2024
Constitutionally isomeric peptides are a class of molecules with the same composition but different connections, ultimately exhibiting significant variation in properties. In this review, we survey recent advances rational design constitutionally and preparation discrete assemblies. Then, examine their applications as templates for inorganic nanoparticle growth, biofilm elimination, or carriers on-demand gas/drug delivery. At end, both future outlooks upcoming challenges emerging research topic also discussed. It is our hope that review will give insight into how subtle modulation peptide sequence would generate dramatic change resultant property.
Language: Английский
Citations
10
Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 343, P. 122461 - 122461
Published: July 3, 2024
This study reports a pH/magnetic dual-responsive hemicellulose-based nanocomposite hydrogel with nearly 100 % carbohydrate polymer-based and biodegradable polymer compositions for drug delivery. We synthesized pure Fe
Language: Английский
Citations
9
Current Opinion in Solid State and Materials Science, Journal Year: 2025, Volume and Issue: 34, P. 101212 - 101212
Published: Jan. 1, 2025
Language: Английский
Citations
1
Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(37)
Published: May 15, 2024
Abstract Carrier‐free nanodrugs that integrate chemodrugs and other therapeutic agents demonstrate good efficacy minimized side effects, showing promise for combined therapy. However, a key challenge lies in enhancing the bioavailability potential of through controllable assembly process. Herein, carrier‐free photothermal nanodrug (ZPQ NPs) is constructed flavonol‐driven with amine‐substituted perylene diimide enhanced chemo‐photothermal cancer The flavonol, particularly quercetin, facilitates J‐aggregation derivatives within contributes to multiple improvements, including red‐shifted absorption, fluorescence intensity, improved conversion efficiency as well excellent photostability. Moreover, also demonstrates cellular uptake intracellular reactive oxygen species scavenging capability. combination quercetin effect effectively kills cells, alleviates inflammation following Guided by vivo imaging, application ZPQ NPs results complete tumor elimination inhibits recurrence This work presents straightforward strategy constructing exhibit simultaneous enhancements both photophysical properties biological activity.
Language: Английский
Citations
8
Chemistry - A European Journal, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 17, 2025
Abstract Supramolecular polymers are constructed through highly reversible and directionally specific non‐covalent interactions between monomer units. This unique feature enables supramolecular to undergo controlled structural reconfiguration functional transformation in response external stimuli, imparting them with high environmental responsiveness self‐healing properties. In particular, exhibit several advantages compared conventional polymers, such as inherent degradability, the ease of preparation incorporation units, smart various biological stimuli. These characters make promising candidates for intelligent drug delivery systems complex environments. this review, we comprehensively summarize latest developments representative achievements fields, focusing primarily on design synthesis, properties functionalities, practical applications small molecule delivery, gene therapy, protein delivery. Finally, highlight future research directions, multifunctionality, adaptability, personalized therapy. We focus recent studies that address key challenges field, providing rational polymer design, important properties, functionality, understanding strategies. expected advance new platforms systems, offering innovative solutions treatment diseases.
Language: Английский
Citations
0
Advanced Materials, Journal Year: 2025, Volume and Issue: unknown
Published: April 7, 2025
Abstract Precise cancer nanomedicine requires rational molecular instructions of therapeutic agents. Harnessing the structure‐property‐function relationships represents a practical strategy toward smart and effective nanomedicine. A structurally novel hydrogen‐bonded (H‐bonded) supramolecular nanoformulation generated by orthogonal self‐sorting assembly chemo‐prodrug (FPtF) phototherapeutics (BPeB) is here reported, to reach an autonomous with improved anti‐tumor efficacy combining chemo/phototherapy (CT/PT). The high‐fidelity H‐bonding modularity from privileged heterocomplementary diaminopyridine/5‐fluorouracil (DAP/FU) Hamilton wedge/barbiturate (HW/Ba) pairs, respectively enable precise spatial control binding interactions FPtF BPeB, in turn allowing process specific “mix‐and‐match” capability. To directly stimulate phototherapy BPeB via near‐infrared (NIR) light, spectral matched upconversion nanoparticles (UCNPs, β‐NaYF 4 :Yb,Er) are encapsulated simultaneously. As result, polymeric nanomicelles, i.e., F/B/U@PHDO, readily fabricated. Moreover, distinct association constant (Ka) DAP/FU (≈10 2 M −1 ) HW/Ba 4‐5 pairs reflect different strengths stabilities H‐bonds, thus endowing programmable dissociation, accompanied release through pH/thermal‐stimuli. Therapeutic regime appreciated outcomes ultimately accomplished combined CT/PT. opportunities offered design anticipated point new paradigm for therapy.
Language: Английский
Citations
0
Macromolecular Bioscience, Journal Year: 2025, Volume and Issue: unknown
Published: April 22, 2025
Abstract In addition to the 20 standard amino acids that form building blocks of proteins, nature employs alternative create specialized “noncanonical peptides.” These unique peptides, found in organisms from bacteria humans, often exhibit unconventional structures and functionalities, playing critical roles modulating cellular processes, particularly as antibiotics. Their potential has attracted significant interest for designing novel functional materials based on noncanonical peptides. This review highlights recent advances generation application peptide assemblies. It begins with a definition including classic examples showcase their distinct useful biological activities. Then applications assemblies developing anticancer therapeutics are discussed, focusing representative studies demonstrate efficacy versatility targeting tumor cells. Beyond oncology, it is explored how have been utilized biomaterials, regenerative medicine, molecular imaging catalysis. Finally, perspectives offered future directions this rapidly evolving field, emphasizing exciting opportunities remaining challenges will drive continued innovation applying peptide‐based
Language: Английский
Citations
0
Journal of Controlled Release, Journal Year: 2025, Volume and Issue: 379, P. 609 - 620
Published: Jan. 24, 2025
Language: Английский
Citations
0
Published: March 29, 2025
Language: Английский
Citations
0
Reaction Chemistry & Engineering, Journal Year: 2024, Volume and Issue: 9(9), P. 2282 - 2292
Published: Jan. 1, 2024
AIBN initiators decomposed efficiently at the oil–water interface room temperature. The interface-initiated room-temperature polymerization produced ductile ABS copolymer monoliths.
Language: Английский
Citations
2