Footprints in the Sno: investigating the cellular and molecular mechanisms of SNORD116
Open Biology,
Год журнала:
2025,
Номер
15(3)
Опубликована: Март 1, 2025
The
small
nucleolar
RNA
(snoRNA)
SNORD116
is
a
non-coding
of
interest
across
multiple
biomedical
fields
research.
Much
the
investigation
into
has
been
undertaken
in
context
congenital
disease
Prader–Willi
syndrome,
wherein
expression
lost.
However,
emerging
evidence
indicates
wider
roles
various
and
tissue
contexts
such
as
cellular
growth,
metabolism
signalling.
Nevertheless,
conclusive
mechanism
action
for
remains
to
be
established.
Here,
we
review
key
findings
from
these
investigations,
with
aim
identifying
common
elements
which
elucidate
potential
targets
mechanisms
SNORD116.
A
recurring
element
identified
disruption
insulin/IGF-1
PI3K/mTOR
signalling
pathways,
contributing
many
phenotypes
associated
modulation
explored
this
review.
Язык: Английский
Exploring the Relationship Between Immune Cells and Scoliosis by Mendelian Randomization, Colocalization Analysis, and SMR
Mediators of Inflammation,
Год журнала:
2025,
Номер
2025(1)
Опубликована: Янв. 1, 2025
Background:
Scoliosis
is
a
condition
that
can
have
severe
consequences
for
millions
of
individuals
on
an
annual
basis.
Current
research
in
this
field
increasingly
focusing
the
role
immune
system
development
disease.
However,
precise
relationship
between
immunity
and
scoliosis
remains
to
be
fully
elucidated.
Method:
Our
investigation
involved
comprehensive
Mendelian
randomization
(MR)
analysis
explore
potential
causal
cells
scoliosis.
The
univariable
MR
encompassed
731
their
with
Cochran's
Q
test,
leave-one-out
MR-Egger
intercept
were
used
assess
pleiotropy
heterogeneity.
We
performed
multivariable
account
confounding
factors
cells.
colocalization
summary
data-based
(SMR)
utilized
cis-eQTL.
Results:
study
identified
13
significantly
associated
by
MR,
including
four
risk
nine
protective
In
order
reduce
cells,
was
employed,
it
determined
only
six
cell
types
had
independent
effects
SERPINH1
shared
same
variant
CX3CR1
CD14-
CD16-.
FSD1L
CCR2
SNHG14,
SNORA33,
NET1,
SNORD100
HLA
DR
CD14+
CD16+
monocyte.
Conclusion:
findings
suggested
possible
link
found
key
genes
cell,
which
provides
new
direction
further
research.
specific
underlying
mechanisms
require
future
experiments.
Язык: Английский
Subverting the Canon: Novel Cancer-Promoting Functions and Mechanisms for snoRNAs
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(5), С. 2923 - 2923
Опубликована: Март 2, 2024
Small
nucleolar
RNAs
(snoRNAs)
constitute
a
class
of
intron-derived
non-coding
ranging
from
60
to
300
nucleotides.
Canonically
localized
in
the
nucleolus,
snoRNAs
play
pivotal
role
RNA
modifications
and
pre-ribosomal
processing.
Based
on
types
they
involve,
such
as
methylation
pseudouridylation,
are
classified
into
two
main
families—box
C/D
H/ACA
snoRNAs.
Recent
investigations
have
revealed
unconventional
synthesis
biogenesis
strategies
snoRNAs,
indicating
their
more
profound
roles
pathogenesis
than
previously
envisioned.
This
review
consolidates
recent
discoveries
surrounding
provides
insights
mechanistic
cancer.
It
explores
intricate
interactions
within
signaling
pathways
speculates
potential
therapeutic
solutions
emerging
snoRNA
research.
In
addition,
it
presents
findings
long
small
host
gene
(lncSNHG),
subset
(lncRNAs),
which
transcripts
parental
SNHGs
that
generate
snoRNA.
The
functional
epicenter
is
also
discussed.
Through
deconstruction
driving
snoRNA-induced
oncogenesis,
this
aims
serve
roadmap
guide
future
research
nuanced
field
snoRNA–cancer
inspire
snoRNA-related
cancer
therapies.
Язык: Английский
How does orthodontic tooth movement influence the dental pulp? RNA‐sequencing on human premolars
International Endodontic Journal,
Год журнала:
2024,
Номер
57(12), С. 1783 - 1801
Опубликована: Июль 31, 2024
The
objective
of
this
study
is
to
analyse
the
gene
expression
profile
dental
pulp
(DP)
human
premolars
subjected
7
and
28
days
orthodontic
force
(OF)
in
vivo
by
using
RNA
sequencing.
maxillary
mandibular
DP
were
additionally
compared.
Язык: Английский
Identifying Associations between Small Nucleolar RNAs and Diseases via Graph Convolutional Network and Attention Mechanism
IEEE Journal of Biomedical and Health Informatics,
Год журнала:
2024,
Номер
28(12), С. 7647 - 7658
Опубликована: Июль 9, 2024
Research
has
shown
that
small
nucleolar
RNAs
(snoRNAs)
play
crucial
roles
in
various
biological
processes,
and
understanding
disease
pathogenesis
by
studying
their
relationship
with
diseases
is
beneficial.
Currently,
known
associations
are
insufficient,
conventional
experiments
costly
time-consuming.
Therefore,
developing
efficient
computational
methods
for
identifying
potential
snoRNA-disease
associations.
In
this
paper,
a
method
to
identify
based
on
graph
convolutional
network
multi-view
attention
mechanism
(GCASDA)
proposed.
Firstly,
the
similarity
matrices
of
snoRNAs
calculated
entity-related
information,
weights
edges
between
snoRNA
nodes
supplemented
random
forest.
Then
two
homogeneous
graphs
one
heterogeneous
constructed.
Subsequently,
different
types
embedded
features
extracted
from
using
specific
structure
integrated
through
obtain
node
feature
representations.
Finally,
each
pair
nodes,
addition
global
features,
interaction
passed
together
multilayer
perceptron
neural
(MLP)
Experimental
results
show
GCASDA
achieves
0.9356
0.9294
AUC
AUPR,
respectively,
significantly
outperformed
other
state-of-the-art
basis
evaluation
metrics.
Furthermore,
case
study
could
further
demonstrate
realistic
feasibility
GCASDA.
Язык: Английский
Small nucleolar RNAs and the brain: Growing evidence supporting their role in psychiatric disorders.
Biological Psychiatry Global Open Science,
Год журнала:
2024,
Номер
5(2), С. 100415 - 100415
Опубликована: Ноя. 10, 2024
Noncoding
RNAs
comprise
most
of
the
transcriptome
and
represent
an
emerging
area
research.
Among
them,
small
nucleolar
(snoRNAs)
have
emerged
as
a
promising
target
because
they
been
associated
with
development
evolution
several
diseases,
including
psychiatric
disorders.
snoRNAs
are
expressed
in
brain,
some
showing
brain-specific
expression
that
indicates
specific
roles
brain
development,
function,
dysfunction.
However,
role
conditions
affect
needs
further
investigation
to
be
better
understood.
This
scoping
review
summarizes
existing
literature
on
studies
investigated
psychiatry
offers
insight
into
potential
pathophysiological
mechanisms
future
Язык: Английский