Biology,
Год журнала:
2024,
Номер
13(8), С. 638 - 638
Опубликована: Авг. 20, 2024
Depression,
a
significant
mental
health
disorder,
is
under
intense
research
scrutiny
to
uncover
its
molecular
foundations.
Epigenetics,
which
focuses
on
controlling
gene
expression
without
altering
DNA
sequences,
offers
promising
avenues
for
innovative
treatment.
This
review
explores
the
pivotal
role
of
epigenetics
in
depression,
emphasizing
two
key
aspects:
(I)
identifying
epigenetic
targets
new
antidepressants
and
(II)
using
personalized
medicine
based
distinct
profiles,
highlighting
potential
focal
points
such
as
methylation,
histone
structure
alterations,
non-coding
RNA
molecules
miRNAs.
Variations
methylation
individuals
with
depression
provide
opportunities
target
genes
that
are
associated
neuroplasticity
synaptic
activity.
Aberrant
acetylation
may
indicate
antidepressant
strategies
involve
enzyme
modifications.
Modulating
miRNA
levels
can
reshape
depression-linked
expression.
The
second
section
discusses
profiles.
Analyzing
these
patterns
could
identify
biomarkers
treatment
response
susceptibility
facilitating
tailored
treatments
proactive
care.
Addressing
ethical
concerns
regarding
information,
privacy
stigmatization,
crucial
understanding
biological
basis
depression.
Therefore,
researchers
must
consider
issues
when
examining
disorders.
importance
critical
aspect
modern
medical
research.
These
findings
hold
great
novel
medications
treatments,
would
significantly
improve
patient
outcomes,
transform
psychiatry.
As
progresses,
it
expected
more
complex
aspects
processes
enhance
our
comprehension,
increase
effectiveness
therapies.
Non-coding RNA Research,
Год журнала:
2024,
Номер
9(4), С. 1222 - 1234
Опубликована: Май 20, 2024
Ferroptosis,
a
form
of
regulated
cell
death,
has
emerged
as
crucial
process
in
diverse
pathophysiological
states,
encompassing
cancer,
neurodegenerative
ailments,
and
ischemia-reperfusion
injury.
The
glutathione
(GSH)-dependent
lipid
peroxidation
pathway,
chiefly
governed
by
peroxidase
4
(GPX4),
assumes
an
essential
part
driving
ferroptosis.
GPX4,
the
principal
orchestrator
ferroptosis,
garnered
significant
attention
across
cardiovascular,
neuroscience
domains
over
past
decade.
Noteworthy
investigations
have
elucidated
indispensable
functions
ferroptosis
numerous
diseases,
including
tumorigenesis,
wherein
robust
within
cells
can
impede
tumor
advancement.
Recent
research
underscored
complex
regulatory
role
non-coding
RNAs
(ncRNAs)
regulating
GSH-GPX4
network,
thus
influencing
cellular
susceptibility
to
This
exhaustive
review
endeavors
probe
into
multifaceted
processes
which
ncRNAs
control
network
Specifically,
we
delve
miRNAs,
lncRNAs,
circRNAs
GPX4
expression
impacting
Moreover,
discuss
clinical
implications
dysregulated
interactions
between
several
conditions,
underscoring
their
capacity
viable
targets
for
therapeutic
intervention.
Additionally,
explores
emerging
strategies
aimed
at
targeting
modulate
pathway
manipulate
advantage.
A
comprehensive
understanding
these
intricate
networks
furnishes
insights
innovative
avenues
diseases
associated
with
perturbed
thereby
laying
groundwork
interventions
ferroptosis-related
pathological
conditions.
Frontiers in Molecular Biosciences,
Год журнала:
2024,
Номер
11
Опубликована: Июнь 3, 2024
Leading
anti-tumour
therapeutic
strategies
typically
involve
surgery
and
radiotherapy
for
locally
advanced
(non-metastatic)
cancers,
while
hormone
therapy,
chemotherapy,
molecular
targeted
therapy
are
the
current
treatment
options
metastatic
cancer.
Despite
initially
high
sensitivity
rate
to
anticancer
therapies,
a
large
number
of
patients
develop
resistance,
leading
poor
prognosis.
The
mechanisms
related
drug
resistance
highly
complex,
long
non-coding
RNAs
appear
play
crucial
role
in
these
processes.
Among
these,
lncRNA
homeobox
transcript
antisense
intergenic
RNA
(HOTAIR),
widely
implicated
cancer
initiation
progression,
likewise
plays
significant
resistance.
It
can
modulate
cell
activities
such
as
proliferation,
apoptosis,
hypoxia,
autophagy,
well
epithelial-mesenchymal
transition,
thereby
contributing
development
resistant
tumour
cells.
In
this
manuscript,
we
describe
different
antitumor
which
HOTAIR
is
involved
suggest
its
potential
predictive
biomarker
management
patients.
Genes,
Год журнала:
2025,
Номер
16(2), С. 140 - 140
Опубликована: Янв. 24, 2025
Amidst
the
prevalent
and
notable
characteristic
of
a
hypoxic
microenvironment
present
in
majority
solid
tumors,
burgeoning
number
studies
have
revealed
significance
noncoding
RNAs
(ncRNAs)
tumor
regions.
The
transcriptome
cancers
is
highly
heterogeneous,
with
transcripts
playing
crucial
roles.
Long
(lncRNAs)
circular
(circRNAs)
are
two
distinctive
classes
ncRNA
that
garnering
increasing
attention.
Biologically,
they
possess
intriguing
properties
significant
regulatory
functions.
Clinically,
as
promising
biomarkers
therapeutic
targets.
Additionally,
recent
research
has
evaluated
clinical
applications
these
ncRNAs
RNA-based
treatments
noninvasive
liquid
biopsies.
This
review
provides
comprehensive
summary
on
lncRNAs
circRNAs
within
microenvironment.
Furthermore,
cancer
diagnosis
treatment
emphasized,
which
could
pave
way
for
development
effective
targeted
therapies.
