Botox-A induced apoptosis and suppressed cell proliferation in fibroblasts pre-treated with breast cancer exosomes

Molecular and Cellular Probes, Год журнала: 2025, Номер 79, С. 102007 - 102007

Опубликована: Янв. 6, 2025

Язык: Английский

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Regulatory role of PPAR in colorectal cancer

Cell Death Discovery, Год журнала: 2025, Номер 11(1)

Опубликована: Янв. 28, 2025

Язык: Английский

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Long non-coding RNAs: Emerging regulators of invasion and metastasis in pancreatic cancer

Journal of Advanced Research, Год журнала: 2025, Номер unknown

Опубликована: Фев. 1, 2025

The invasion and metastasis of pancreatic cancer (PC) are key factors contributing to disease progression poor prognosis. This process is primarily driven by EMT, which has been the focus recent studies highlighting role long non-coding RNAs (lncRNAs) as crucial regulators EMT. However, mechanisms lncRNAs influence invasive multifaceted, extending beyond EMT regulation alone. review aims characterize affecting in cancer. We summarize regulatory roles across multiple molecular pathways highlight their translational potential, considering implications for clinical applications diagnostics therapeutics. focuses on three principal scientific themes. First, we orchestrate various signaling pathways, such TGF-β/Smad, Wnt/β-catenin, Notch, regulate changes associated with thereby enhancing cellular motility invasivenes. Second, effects autophagy ferroptosis discuss exosomal tumor microenvironment behavior neighboring cells promote cell invasion. Third, emphasize RNA modifications (such m6A m5C methylation) stabilizing capacity mediate PC. Lastly, potential these findings, emphasizing inherent challenges using biomarkers therapeutic targets, while proposing prospective research strategies.

Язык: Английский

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Flavonoids as modulators of miRNA expression in pancreatic cancer: Pathways, Mechanisms, And Therapeutic Potential

Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 179, С. 117347 - 117347

Опубликована: Сен. 5, 2024

Язык: Английский

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Exosomal PSM-E inhibits macrophage M2 polarization to suppress prostate cancer metastasis through the RACK1 signaling axis

Biomarker Research, Год журнала: 2024, Номер 12(1)

Опубликована: Ноя. 14, 2024

Abstract Background It is well-established that understanding the mechanism of prostate cancer (PCa)-associated metastasis paramount for improving its prognosis. Metastasis known to involve communication between tumor-associated macrophages (TAMs) and tumor cells. Exosomes are crucial in mediating this intercellular within microenvironment. Nonetheless, role exosomal proteins PCa not yet fully understood. Here, we investigated mechanisms cancer-derived PSM-E on regulating macrophage M2 polarization suppress invasion metastasis. Methods levels exosomes were detected by transmission electron microscopy Western blotting analysis. The diagnostic value urine-derived evaluated LC-MS/MS, correlation analysis, ROC curves underlying inhibitory effect was co-IP, IHC staining, tumorigenesis model, etc. Results We revealed upregulated derived from serum urine patients. Clinically, an elevated expression significantly correlated with advanced pathological stage a high Gleason score. Our research also inhibits cell proliferation, invasion, suppressing vitro vivo. Furthermore, provided compelling evidence recruiting RACK1 FAK ERK signaling pathways, consequently found protease-associated domain fourth tryptophan-aspartate repeat interaction RACK1. Conclusions Notably, carrying could potentially serve as biomarker PCa, targeting may represent strategy preventing progression patient population.

Язык: Английский

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Role of lncRNA PVT1 in the progression of urological cancers: Novel insights into signaling pathways and clinical opportunities

Cellular Signalling, Год журнала: 2025, Номер unknown, С. 111736 - 111736

Опубликована: Март 1, 2025

Язык: Английский

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Immune prognostic model for glioblastoma based on the ssGSEA enrichment score

Cancer Genetics, Год журнала: 2025, Номер 294-295, С. 32 - 41

Опубликована: Март 22, 2025

Язык: Английский

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A Bioligical Perspective on the role of miR-206 in Colorectal cancer

Gene, Год журнала: 2025, Номер unknown, С. 149552 - 149552

Опубликована: Май 1, 2025

Язык: Английский

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Targeting ferroptosis for precision medicine in cervical cancer

APOPTOSIS, Год журнала: 2025, Номер unknown

Опубликована: Май 7, 2025

Язык: Английский

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The Immunomodulatory Effects of Vitamin D on COVID-19 Induced Glioblastoma Recurrence via the PI3K-AKT Signaling Pathway

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(23), С. 12952 - 12952

Опубликована: Дек. 2, 2024

Glioma is a highly invasive brain cancer that difficult to treat due its complex molecular characteristics and poor prognosis. The COVID-19 pandemic has introduced additional clinical challenges for patients, especially those with glioma. This study explored the interactions between glioma using integrated bioinformatics methods, including enrichment analysis, survival docking, focusing on PI3K-Akt signaling pathway immunomodulatory role of vitamin D. From gene expression data COVID-19, 203 common differentially expressed genes were identified, six prognostic key genes-MYBL2, RBM6, VEPH1, AHNAK2, GNG10, DUSP14-were further determined. After intersecting D targets five determined-MYBL2, AHNAK2 GNG10. These play significant roles in potentially interact Molecular docking single-cell RNA sequencing analyses suggest may improve prognosis patients infected by regulating these pathway. findings reveal links thereby providing new insights developing targeted therapeutic strategies.

Язык: Английский

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