Pathology - Research and Practice, Год журнала: 2024, Номер 263, С. 155657 - 155657
Опубликована: Окт. 16, 2024
Язык: Английский
Ageing Research Reviews, Год журнала: 2024, Номер 102, С. 102545 - 102545
Опубликована: Окт. 17, 2024
Язык: Английский
Процитировано
13
Cell Communication and Signaling, Год журнала: 2025, Номер 23(1)
Опубликована: Март 18, 2025
Protein quality control (PQC) plays a vital role in maintaining normal heart function, as cardiomyocytes are relatively sensitive to misfolded or damaged proteins, which tend accumulate under pathological conditions. Ubiquitin-specific protease (USP) is the largest deubiquitinating enzyme family and key component of ubiquitin proteasome system (UPS), non-lysosomal protein degradation machinery mediate PQC cells. USPs regulate stability activity target proteins that involve intracellular signaling, transcriptional inflammation, antioxidation, cell growth. Recent studies demonstrate can fibrosis, lipid metabolism, glucose homeostasis, hypertrophic response, post-ischemic recovery death such apoptosis ferroptosis cardiomyocytes. Since myocardial loss an important cardiomyopathy, therefore, these findings suggest UPSs play emerging roles cardiomyopathy. This review briefly summarizes recent literature on regulatory occurrence development giving us new insights into molecular mechanisms different cardiomyopathy potential preventive strategies for
Язык: Английский
Процитировано
1
Regenerative Therapy, Год журнала: 2025, Номер 29, С. 352 - 363
Опубликована: Апрель 8, 2025
Язык: Английский
Процитировано
0
BULLETIN OF STOMATOLOGY AND MAXILLOFACIAL SURGERY, Год журнала: 2025, Номер unknown, С. 128 - 143
Опубликована: Май 18, 2025
The TGF-β signalling pathway is an enigmatic player with a tumor suppressor effect in HPV-positive head and neck cancer during the initial stages of cancer, but has pro-cancer later stages. Specifically, oropharyngeal carcinomas are characterized by suppression due to virus's changes cells. In stage works pro-apoptotic anti-proliferative, while stages, it involved immune checkpoint, metastasis, chemoresistance. This duality presents major problems for therapeutic intervention as modulation tumor-promoting effects requires sparing its tumor- suppressing properties. However, recent studies have reported novel approaches such selective inhibitors, checkpoint blockade, combined targeted therapy HPV oncoproteins pathway. These present some promise enhancing clinical results; however, more research required realize these benefits benefit patients. review examines complex role cancers discusses implications future development.
Язык: Английский
Процитировано
0
Biology Direct, Год журнала: 2024, Номер 19(1)
Опубликована: Дек. 19, 2024
UCHL5 was initially recognized as a multifunctional molecule. While recent research has highlighted its involvement in tumor malignant biological behaviors, specific role promoting cell apoptosis drawn particular attention. However, the precise relationship between and various types, well influence within immune microenvironment, remains unclear. The transcriptomic data clinicopathological parameters across 33 cancer types were obtained from TCGA. Clinical pathological of patients, including gender, age, survival time, staging, are utilized to evaluate association pan-cancer characteristics. prognostic significance evaluated through Cox analysis Kaplan-Meier (K-M) methods. Protein expression for Human Atlas database, subcellular localization further investigated. Additionally, potential correlations factors such tumor-infiltrating cells, immunomodulators, microsatellite instability (MSI), mutation burden (TMB) explored. immunotherapy efficacy also assessed independent cohorts, IMvigor210, GSE78220, GSE67501, GSE168204. Finally, impact on behavior cervical cells investigated vitro experiments, along with an exploration underlying mechanisms. We observed that levels elevated 11 tissues compared their corresponding normal tissues, while lower five types. displayed significant correlation stage BRCA, KIRC, LUAD, TGCT. K-M indicated significantly associated prognosis KICH, CESC, ACC, UVM. negatively stromal scores certain cancers. In terms infiltration, UCEC, SKCM, COAD showed negative regulatory T (Tregs). Furthermore, widely three immunomodulators. It demonstrated MSI TMB cancers connected efficacy. experiments confirmed knockout enhances disrupts Wnt/β-catenin signaling. Pan-cancer indicates is dysregulated closely prognosis, shows promise predictive biomarker, mechanisms different warrant investigation.
Язык: Английский
Процитировано
2
Pathology - Research and Practice, Год журнала: 2024, Номер 263, С. 155614 - 155614
Опубликована: Сен. 25, 2024
Язык: Английский
Процитировано
1
Pathology - Research and Practice, Год журнала: 2024, Номер 263, С. 155659 - 155659
Опубликована: Окт. 16, 2024
Язык: Английский
Процитировано
1
Biogerontology, Год журнала: 2024, Номер 26(1)
Опубликована: Дек. 26, 2024
Язык: Английский
Процитировано
1
Pathology - Research and Practice, Год журнала: 2024, Номер 263, С. 155641 - 155641
Опубликована: Окт. 3, 2024
Язык: Английский
Процитировано
0
Pathology - Research and Practice, Год журнала: 2024, Номер 263, С. 155657 - 155657
Опубликована: Окт. 16, 2024
Язык: Английский
Процитировано
0