Antimicrobial Transformation Products in the Aquatic Environment: Global Occurrence, Ecotoxicological Risks, and Potential of Antibiotic Resistance

Environmental Science & Technology, Год журнала: 2023, Номер 57(26), С. 9474 - 9494

Опубликована: Июнь 19, 2023

The global spread of antimicrobial resistance (AMR) is concerning for the health humans, animals, and environment in a One Health perspective. Assessments AMR associated environmental hazards mostly focus on parent compounds, while largely overlooking their transformation products (TPs). This review lists TPs identified surface water environments examines potential promotion, ecological risk, as well human using silico models. Our also summarizes key compartments TPs, related pathways reaching waters methodologies studying fate TPs. 56 covered by were prioritized via scoring ranking various risk hazard parameters. Most data occurrences to date have been reported Europe, little known about antibiotic Africa, Central South America, Asia, Oceania. Occurrence antiviral other antibacterial are even scarcer. We propose evaluation structural similarity between compounds TP assessment. predicted 13 especially tetracyclines macrolides. estimated ecotoxicological effect concentrations from experimental chemical bacteria, algae fleas, scaled potency differences quantitative structure–activity relationships (QSARs) baseline toxicity scaling factor similarity. Inclusion mixtures with increased quotient over threshold one 7 24 antimicrobials included this analysis, only had above one. Thirteen which 6 macrolide posed at least three tested species. There 12/21 that likely exhibit similar or higher level mutagenicity/carcinogenicity, respectively, than compound, tetracycline often showing mutagenicity. carcinogenicity belonged sulfonamides. be mobile but not bioaccumulative, 14 persistent. six highest-priority originated family antivirals. review, particular our concern, can support authorities planning intervention strategies source mitigation toward sustainable future.

Язык: Английский

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Nanocomposite PVDF/TiO2 Photocatalytic Membranes for Micropollutant Removal in Secondary Effluent

Catalysts, Год журнала: 2024, Номер 14(2), С. 109 - 109

Опубликована: Янв. 28, 2024

In this study, a mixed-matrix method was used to prepare PVDF polymeric membranes with different amounts of TiO2 P25 photocatalyst embedded, which were employed in filtration processes the presence UV radiation (LED, peak emission at 375 nm) eliminate two aqueous micropollutants (MPs) as model compounds (venlafaxine and metoprolol). The obtained characterized gain insights into their texture, morphology, composition, other catalyst-related properties that could affect photocatalytic process. For purpose, N2 adsorption–desorption, contact angle, SEM-EDX, thermal analysis, FTIR, XPS, UV-vis DRS, PL spectroscopy used. Filtration tests carried out continuous mode using dead-end cell evaluate performance prepared removing selected MPs. Experiments performed both ultrapure water secondary effluent from municipal wastewater treatment plant. It found synthesized effectively remove target MPs water, achieving up 99% elimination. Such process decreased drastically removals below 35%. Carbonate/bicarbonate ions identified main scavenging substances. Thus, after partial removal carbonate/bicarbonate effluent, achieved above 60%.

Язык: Английский

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Antidepressants and their metabolites primarily affect lysosomal functions in the marine mussel, Mytilus galloprovincialis

The Science of The Total Environment, Год журнала: 2023, Номер 903, С. 166078 - 166078

Опубликована: Авг. 11, 2023

Antidepressants widely occur as emerging contaminants in marine coastal waters, with concentrations reported the low ng/L range. Although at relatively lower levels respect to other pharmaceuticals, antidepressants - fluoxetine (FLX) particular have attracted attention because of their striking effects exerted doses on invertebrates. In this study, four including FLX, sertraline (SER), and citalopram, members selective serotonin reuptake inhibitor (SSRI) class, venlafaxine (VEN) a member norepinephrine (SNRI) were evaluated mussel Mytilus galloprovincialis. addition, two main metabolites FLX VEN, i.e., norfluoxetine (NFL) O-desmethylvenlafaxine (ODV) respectively, compared those parent compounds. Eight each drug (0.5-500 range) tested early life stage endpoints gamete fertilization larval development 48 h post (hpf). Egg was reduced by all compounds, except for VEN. Larval hpf affected SSRIs, but not SNRIs. The above significant never exceeded 20 % control values. Adult mussels exposed vivo 7 days environmental drugs (0.5, 5, 10 ng/L) battery eight biomarkers assessed. primarily targeted lysosomal functions, decreasing haemocyte lysosome membrane stability (up 70 reduction) increasing lysosome/cytosol ratio 220 %), neutral lipid 230 lipofuscin 440 %) accumulation digestive gland. Only SER NFL significantly catalase glutathione-S-transferase activities gills ODV, effective sometimes more active than All compounds impaired health status, indicated high stress assigned using Mussel Expert System.

Язык: Английский

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A solar flow photo-reactor for antibiotic removal from aquaculture effluents using TiO2/carbon quantum dots

Chemosphere, Год журнала: 2023, Номер 348, С. 140723 - 140723

Опубликована: Ноя. 16, 2023

Effluents contaminated with antibiotics must be treated before reuse or even discharge into the aquatic environment, avoiding increase of antimicrobial resistance (AMR) - a major public health problem 21st century. Little is known regarding natural solar photodegradation in tubular reactors operated under flow mode and less concerning application photocatalysts. The use photocatalysts considered promising strategy for sustainable solar-driven removal from effluents. In this work, two widely used aquaculture, namely, sulfadiazine (SDZ) oxolinic acid (OXA), was investigated absence presence carbon quantum dots (CQDs) coupled titanium dioxide (TiO2) (4% (w/w)). obtained results showed that TiO2/CQDs (w/w)) enhanced both antibiotics, which highly beneficial their treatment aquaculture accumulated UV energy needed SDZ using photocatalyst than 4 kJ L-1 simulated freshwater (phosphate buffer solution (PBS)) brackish water (sea salt (SSS)), while OXA 5 around 15 were PBS SSS, respectively. Moreover, demonstrated proposed photocatalytic also efficient elimination antibacterial activity, either SSS. Therefore, photocatalysis constitutes antibiotics'

Язык: Английский

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Photoproduction of reactive intermediates from dissolved organic matter in coastal seawater around an urban metropolis in South China: Characterization and predictive modeling

The Science of The Total Environment, Год журнала: 2024, Номер 921, С. 170998 - 170998

Опубликована: Фев. 15, 2024

Язык: Английский

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Transcriptional modulation in Mediterranean Mussel Mytilus galloprovincialis following exposure to four pharmaceuticals widely distributed in coastal areas

Aquatic Toxicology, Год журнала: 2025, Номер 279, С. 107255 - 107255

Опубликована: Янв. 24, 2025

Ecotoxicological risk and the mode of action human drugs on non-target marine animals remain unclear, keeping a gap knowledge risks related to ecosystem disruption chemical contamination food chains. Understanding these impacts is critical developing proper waste management practices regulatory frameworks prevent long-term environmental health problems. This study investigates Gemfibrozil, Metformin, Ramipril, Venlafaxine, individually combined Mytilus galloprovincialis over 30 days assesses persistent effects post-recovery using RNA-seq 16S rRNA microbiota profiling. All pharmaceuticals caused few changes in while gene expression analyses highlighted drug-specific alterations. Gemfibrozil exposure led alterations lipid fatty acid metabolism, suggesting similar that observed target species. Metformin significantly impacted mussels' energy with disruptions specific genes pathways potentially glucose uptake insulin signaling. was also treatment leading most significant predicted functional profiles microbiota, it may influence microbiota's potential interact host metabolism. Ramipril resulted up-regulation stress response cell cycle regulation Venlafaxine induced serotonin synapse pathways, indicating similarities mechanisms Mixture four severely mussel physiology, including impairment oxidative phosphorylation compensatory activation several involved Despite recovery after depuration, metabolism suggests from pharmaceutical exposure. Notably, mTOR1 signaling all treatments underscores its key role coordinating bivalve responses. The Transcriptomic Hazard Index (THI) calculated for each indicates major/severe hazards decreased slight/moderate depuration.

Язык: Английский

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Electrochemical Degradation of Venlafaxine on Platinum Electrodes: Identification of Transformation Products by LC-MS/MS and In Silico Ecotoxicity Assessment

Molecules, Год журнала: 2025, Номер 30(9), С. 1881 - 1881

Опубликована: Апрель 23, 2025

Antidepressants are emerging contaminants that have raised global concern due to their abuse. Venlafaxine (VFX), a serotonin and norepinephrine reuptake inhibitor, can cause adverse potentially toxic effects on aquatic organisms. Electrochemical advanced oxidation processes (EAOPs) gaining attention as promising degradation techniques for variety of drugs. EAOP methods proposed VFX mainly utilize boron-doped diamond (BDD) electrodes, characterized by low background current high oxygen overpotential. However, challenges arise, including delamination from the substrate, difficulties in scaling up, limited service life. In this study, platinum was employed an anode galvanostatic VFX, its stability well-established surface cleaning procedure, which ensured reproducibility. A 0.1 M Na2SO4 solution at pH 9 used supporting electrolyte, density 25 mA/cm2 applied. After 7 h, efficiency 94% achieved ppm solution. The hydroxyl sulfate radicals generated electrochemical system were active species responsible degradation, followed first-order kinetic model with rate constant 0.0084 min−1. main intermediates identified through LC-MS, two isomers nominal m/z 276 three 294. toxicity products assessed silico prediction model. This evaluation confirmed sustainability developed method.

Язык: Английский

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A review of hybrid enzymatic-chemical treatment for wastewater containing antiepileptic drugs

Environmental Science and Pollution Research, Год журнала: 2023, Номер 30(27), С. 69857 - 69881

Опубликована: Май 15, 2023

Язык: Английский

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Environmental Persistence of the Antidepressant Fluoxetine and Its Pharmaceutical Alternative: Kinetics of Oxidation and Mathematical Simulations

Water, Год журнала: 2022, Номер 14(21), С. 3536 - 3536

Опубликована: Ноя. 3, 2022

To investigate the impact of antidepressants (ANT) in water, estimates direct and indirect photolysis standard fluoxetine hydrochloride (FLX) a pharmaceutical alternative, sulfate (FLXSO4), were evaluated. The second-order kinetic constants ANT reactive photoinduced species (RPS) (singlet oxygen, 1O2; hydroxyl radicals, HO•; triplet excited states chromophoric dissolved organic matter, 3CDOM*) obtained by competition kinetics under simulated solar radiation. These parameters used combination with water characteristics to assess environmental persistence based on mathematical simulations. results indicated that reactions HO• (kFLX,HO• = (2.54 ± 0.06) × 109 L mol−1 s−1; kFLXSO4,HO• (3.07 0.03) s−1) 3CDOM* (kFLX,3CDOM* (2.67 0.05) kFLXSO4,3CDOM* (1.48 play more important role degradation compared 1O2 (kFLX,1O2 (1.37 0.07) 107 kFLXSO4,1O2 (1.63 0.33) s−1). main removal pathways biodegradation following order FLX > FLXSO4. Therefore, presence anions can contribute sunlit waters.

Язык: Английский

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Mechanism and Kinetics of The Degradation of Nitazoxanide and Hydroxychloroquine Drugs by Hydroxyl Radicals: Theoretical Approach to Ecotoxicity

Journal of the Brazilian Chemical Society, Год журнала: 2023, Номер unknown

Опубликована: Янв. 1, 2023

The efforts of contrasting the effects caused by Covid-19 (coronavirus disease 2019) pandemic increased disposal active pharmaceutical ingredients. This paper reports mechanisms and kinetics degradation in aqueous environments induced  OH two drugs, among those most widely probed at outbreak coronavirus, nitazoxanide hydroxychloroquine. investigation exploits quantum chemistry techniques a reaction rate theory combined with diffusion-controlled processes mechanical tunneling. constants are obtained an environmentally relevant temperature range. results show that (i) deacetylation formation tizoxanide is kinetically favorable channel, agreement experimental work; (ii) for hydroxychloroquine, present theoretical calculations channel addition aromatic ring. half-life time products both cases range between 12 to 138 days. Both drugs presented toxicities harmful toxic as computational toxicology calculations: toxicity also calculated products: process, was characterized more toxic, while case major product showed decrease toxicity.

Язык: Английский

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