Molecular basis for the effects of SSRIs in non-target aquatic invertebrates: a case study with Mytilus galloprovincialis early larvae

Aquatic Toxicology, Год журнала: 2025, Номер 282, С. 107306 - 107306

Опубликована: Март 1, 2025

Язык: Английский

---

Hemolymph responses of the Thai freshwater mussel Hyriopsis bialata exposed to atrazine

Journal of Hazardous Materials, Год журнала: 2025, Номер 492, С. 138064 - 138064

Опубликована: Март 29, 2025

Язык: Английский

---

Exposure to environmental pharmaceuticals affects the macromolecular composition of mussels digestive glands

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Апрель 23, 2024

Abstract Human pharmaceuticals represent a major challenge in natural environment. A better knowledge on their mechanisms of action and adverse effects cellular pathways is fundamental to predict long-term consequences for marine wildlife. The FTIRI Imaging (FTIRI) spectroscopy represents vibrational technique allowing map specific areas non-homogeneous biological samples, providing unique biochemical ultrastructural fingerprint the tissue. In this study, has been applied, first time, characterize (i) chemical building blocks digestive glands Mytilus galloprovincialis , (ii) alterations (iii) resilience macromolecular composition, after 14-days exposure 0.5 µg/L carbamazepine (CBZ), valsartan (VAL) mixture, followed by recovery period. Spectral features mussels provided insights composition topographical distribution main groups macromolecules, such as proteins, lipids, glycosylated compounds. Pharmaceuticals caused an increase total amount protein significant decrease lipids levels. Changes reflected modulation molecular thus supporting our emerging pollutants. Overall, applied approach could added value within integrated strategies effects-based evaluation environmental contaminants.

Язык: Английский

---

Drug–Drug Interactions of Selective Serotonin Reuptake Inhibitors: A Pharmacovigilance Study on Real-World Evidence from the EudraVigilance Database

Pharmaceuticals, Год журнала: 2024, Номер 17(10), С. 1278 - 1278

Опубликована: Сен. 26, 2024

As the most common psychiatric symptom, depression represents a subject of high interest for medical community.

Язык: Английский

---

Differential bioconcentration and sensitivity of Dreissena polymorpha and Dreissena rostriformis bugensis to the antidepressant sertraline

Journal of Hazardous Materials, Год журнала: 2024, Номер 482, С. 136628 - 136628

Опубликована: Ноя. 22, 2024

Язык: Английский

---

Low expression of lysosome-related genes KCNE1, NPC2, and SFTPD promote cancer cell proliferation and tumor associated M2 macrophage polarization in lung adenocarcinoma

Heliyon, Год журнала: 2024, Номер 10(6), С. e27575 - e27575

Опубликована: Март 1, 2024

BackgroundRecent research has shown that lysosomes play a critical role in the onset and progression of malignancy by regulating tumor cell death through several mechanisms. Nevertheless, involvement lysosome-associated genes (LSAGs) lung adenocarcinoma (LUAD) is still not well understood.MethodsLSAGs were identified malignant epithelial cells, as biologically functionally annotated comprehensive integration single-cell bulk RNA-sequencing data. Prognostic characterization LSAGs was established, which accuracy reliability assessed one-way Cox LASSO regression. Correlations between LSAG properties immune infiltration, chemotherapy, immunotherapy analyzed integrated omics Finally, we characterized expression three (KCNE1, NPC2, SFTPD) epithelium their impact on related phenotypes.ResultsWe 18 associated with prognosis, 3 used to construct prognostic models. High-risk patients had worse survival model predicted it better than other clinical indicators. Based functional enrichment analyses, binding molecular activity functions, inhibition DNA damage repair growth, IL7 signaling pathway, glycolysis. M0 macrophages M1 substantially enriched high-risk patients. Conversely, there considerable resting dendritic cells M2 at low risk. We also found risk scores outcome immunotherapy. In vitro, KCNE1, SFTPD lowly expressed higher percentage macrophage infiltration. Overexpression suppressed proliferation invasion remarkably reduced polarization cellular secretion pro-tumor cytokines.ConclusionsWe LASGs—KCNE1, SFTPD—to develop validate predictive signature for LUAD Furthermore, promotes cancer polarization. Our study may provide fresh perspectives customized

Язык: Английский

---

Effects of Water Temperature Increase on Transcriptomic, Biochemical, and Histopathological Responses of the Bivalve Species Mytilus Galloprovincialis to the Antineoplastic Drug 5-Fluorouracil

Опубликована: Янв. 1, 2024

Язык: Английский

---

Antidepressants as new endocrine disruptors? – transcriptomic profiling in gonads of Mytilus trossulus exposed to norfluoxetine

Marine Pollution Bulletin, Год журнала: 2024, Номер 208, С. 117015 - 117015

Опубликована: Сен. 20, 2024

Язык: Английский

---

Fate and impact at molecular level of diatrizoic acid and iohexol contrast agents in Dreissena polymorpha mollusks

Environmental Science and Pollution Research, Год журнала: 2024, Номер 31(49), С. 59507 - 59520

Опубликована: Окт. 2, 2024

Язык: Английский

---