International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(11), С. 9581 - 9581
Опубликована: Май 31, 2023
The
intestine
is
critically
crucial
for
nutrient
absorption
and
host
defense
against
exogenous
stimuli.
Inflammation-related
intestinal
diseases,
including
enteritis,
inflammatory
bowel
disease
(IBD),
colorectal
cancer
(CRC),
are
heavy
burdens
human
beings
due
to
their
high
incidence
devastating
clinical
symptoms.
Current
studies
have
confirmed
that
responses,
along
with
oxidative
stress
dysbiosis
as
critical
pathogenesis,
involved
in
most
diseases.
Polyphenols
secondary
metabolites
derived
from
plants,
which
possess
convincible
anti-oxidative
anti-inflammatory
properties,
well
regulation
of
microbiome,
indicating
the
potential
applications
enterocolitis
CRC.
Actually,
accumulating
based
on
biological
functions
polyphenols
been
performed
investigate
functional
roles
underlying
mechanisms
over
last
few
decades.
Based
mounting
evidence
literature,
objective
this
review
outline
current
research
progress
regarding
category,
functions,
metabolism
within
intestine,
prevention
treatment
might
provide
ever-expanding
new
insights
utilization
natural
polyphenols.
Frontiers in Cellular and Infection Microbiology,
Год журнала:
2024,
Номер
14
Опубликована: Авг. 7, 2024
Psoriasis
is
one
of
the
most
common
autoimmune
skin
diseases.
Increasing
evidence
shows
that
alterations
in
diversity
and
function
microbiota
can
participate
pathogenesis
psoriasis
through
various
pathways
mechanisms.
Foods,
Год журнала:
2024,
Номер
13(18), С. 2886 - 2886
Опубликована: Сен. 12, 2024
Atherosclerosis
(AS)
is
a
chronic
inflammatory
vascular
disease.
Dysregulated
lipid
metabolism,
oxidative
stress,
and
inflammation
are
the
major
mechanisms
implicated
in
development
of
AS.
In
addition,
evidence
suggests
that
gut
dysbiosis
plays
an
important
role
atherogenesis,
modulation
microbiota
with
probiotics
phenolic
compounds
has
emerged
as
promising
strategy
for
preventing
treating
It
been
shown
can
improve
atherosclerosis-related
parameters
by
improving
profile,
inflammation.
these
may
modulate
diversity
composition
atherosclerosis.
The
studies
evaluated
present
review
showed
compounds,
when
consumed
individually,
improved
atherosclerosis
modulating
various
ways,
such
decreasing
permeability,
TMAO
LPS
levels,
altering
alpha
beta
diversity,
increasing
fecal
bile
acid
loss.
However,
no
study
was
found
combined
use
to
available
literature
highlights
synergistic
potential
between
their
health-promoting
properties
functionalities.
This
aims
summarize
on
individual
effects
AS,
while
providing
insights
into
benefits
nutraceutical
approaches
using
probiotic
strains,
quercetin,
resveratrol
adjuvant
therapies
AS
treatment
through
microbiota.
Frontiers in Microbiology,
Год журнала:
2025,
Номер
16
Опубликована: Янв. 30, 2025
Introduction
Polygonatum
kingianum
is
a
well-known
medicinal
herb
with
proven
bioactivities;
however,
little
known
about
the
effects
of
its
polysaccharide
on
intestinal
injuries
in
animals
induced
by
lipopolysaccharide
(LPS).
Methods
A
total
30
Institute
Cancer
Research
(ICR)
mice
were
divided
into
control
(CH),
(MH),
and
treated
(H)
groups.
Mice
group
H
supplemented
100
mg/kg
polysaccharides,
while
groups
C
M
same
amount
normal
saline
gavage
for
18
days.
On
th
day
LPS
(10
mg/kg).
Results
The
results
showed
weight
MH
significantly
dropped
(
P
<
0.0001),
PK
had
higher
0.01).
Pathological
analysis
found
that
majority
villi
broken
short,
PK-treated
longer
considerably
integrated
villi.
length
CH
0.0001)
was
than
M,
value
length/crypt
depth
smaller
crypt
0.0001).
Serum
inspection
MAD
0.05),
IL-1β
IL-6
TNF-α
0.01)
MH,
SOD
0.001),
T-AOC
0.01),
GSH-Px
notably
H.
Microbiome
sequencing
obtained
844,477
raw
725,469
filtered
reads.
There
2,407
ASVs
detected
animals,
there
312
328
shared
between
H,
respectively.
5
phyla
20genera
remarkable
bacteria
among
including
genera
Escherichia,
Pseudomonas_E,
Mailhella,
Paramuribaculum
,
NM07-P-09,
Odoribacter,
Nanosyncoccus
SFM01,
Onthenecus,
Clostridium_Q
UBA6985,
Ructibacterium
UBA946,
Lachnoclostridium_B,
Evtepia
CAG-269,
Limivicinus,
Formimonas,
Dehalobacterium,
Dwaynesavagella
UBA6985.
We
revealed
could
alleviate
promoting
oxidation
resistance,
decreasing
inflammatory
responses,
accommodating
microbiota
mice.
Discussion
Our
suggest
possibility
developing
novel
therapies
diseases.
Fatty
liver
hemorrhage
syndrome
(FLHS)
has
become
one
of
the
major
factors
leading
to
death
laying
hen
in
caged
egg
production.
FLHS
is
commonly
associated
with
lipid
peroxidation,
hepatocyte
injury,
decreased
antioxidant
capacity,
and
inflammation.
However,
there
are
limited
evidences
regarding
preventive
effect
Lactiplantibacillus
plantarum
on
hens
its
mechanisms.
Our
previous
results
showed
that
Lp.
FRT4
alleviated
by
regulating
metabolism,
but
did
not
focus
anti-inflammatory
functions
Therefore,
this
study
aimed
investigate
mechanisms
alleviating
FLHS,
a
role
activity
inflammation
regulation.
Supplementation
enhanced
levels
T-AOC,
T-SOD,
GSH-Px,
while
reducing
TNF-α,
IL-1β,
IL-8,
NLRP3
ovary
hens.
Additionally,
upregulated
mRNA
expressions
SOD1,
SOD2,
CAT,
GPX1,
downregulated
pro-inflammatory
IL-6,
NLRP3,
IL-4
IL-10.
improved
structure
metabolic
gut
microbiota,
regulated
relative
abundances
dominant
phyla
(Bacteroidetes,
Firmicute,
Proteobacteria)
genera
(Prevotella
Alistipes).
it
influenced
key
KEGG
pathways,
including
tryptophan
amino
sugar
nucleotide
insulin
signaling
pathway,
FoxO
pathway.
Spearman
analysis
revealed
abundance
microbiota
at
different
taxonomic
was
closely
related
enzymes
inflammatory
factors.
Furthermore,
modulated
FoxO/TLR-4/NF-κB
pathway
microbiota.
Moreover,
E2,
FSH,
VTG
were
significantly
increased
after
intervention.
effectively
ameliorates
This
efficacy
attributed
properties,
which
mediated
modulating
function
further
intervening
These
actions
enhance
hepatic
ovarian
increase
estrogen
levels.
Video
Abstract.
Journal of Agricultural and Food Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 1, 2025
Nonalcoholic
Steatohepatitis
(NASH)
is
a
progressive
liver
disease
characterized
by
inflammation
and
damage.
Allicin,
bioactive
compound
derived
from
garlic,
has
demonstrated
anti-inflammatory
antioxidant
properties.
This
study
explores
the
effects
of
allicin
on
NASH
gut
microbiota
dysbiosis
induced
high-fat,
high-fructose
diet
(HFFD)
in
mice.
Allicin
supplementation
significantly
alleviated
hepatic
inflammation,
improved
glucose
metabolism,
modulated
circadian
rhythm
gene
Rev-erbα,
which
plays
critical
role
regulating
inflammation.
The
were
diminished
Si-Rev-erbα-treated
HepG2
cells,
highlighting
importance
regulation
mediating
these
effects.
Allicin's
associated
with
increased
levels
short-chain
fatty
acids
(SCFAs)
restoration
diurnal
oscillations
proinflammatory
cytokines
composition,
particularly
genera,
such
as
Akkermansia,
Bacteroidetes,
Lactobacillus.
These
findings
suggest
that
could
be
promising
therapeutic
approach
for
managing
NASH,
dysfunction,
related
metabolic
disorders
through
modulation
rhythms
microbiome.
Cuadernos de Educación y Desarrollo,
Год журнала:
2025,
Номер
17(4), С. e7926 - e7926
Опубликована: Апрель 4, 2025
Due
to
the
characterization
of
Autism
Spectrum
Disorder
(ASD)
as
a
multifaceted
syndrome,
most
diagnoses
are
still
not
precise.
To
avoid
pharmacological
treatments,
natural
strategies
with
significant
potential
reduce
oxidative
stress
sought.
This
study
aims
identify
influence
quercetin
on
oral
and
gut
microbiota,
well
evaluate
action
this
bioactive
compound
in
relation
signs
symptoms
that
characterize
ASD
individuals.
research,
is
systematic
review,
was
conducted
PubMed
platform
from
2014
2024.
The
keywords
used
were:
“quercetin
autismo”;
“autism,
antioxidante”;
microbiota”;
intestinal
microbiota.”
Evidences
showed
reduces
under
various
conditions,
both
vitro
vivo,
indicated
mitochondrial
function
optimization
protection
against
xenobiotic-induced
damage.
It
demonstrated
benefits
such
improved
cognitive
function,
reduced
blood
glucose
levels,
activation
SIRT1
enzyme.
preserved
microbial
diversity
dominance
inflammatory
taxonomic
groups.
positively
influenced
microbiota
by
decreasing
Firmicutes
increasing
Bacteroidetes.
could
represent
novel
approach
conditions
related
gut-brain-microbiota
axis.
Studies
suggest
offers
promising
mitigate
physiological
manifestation
challenges,
improve
responses,
act
potent
antioxidant,
modulate
microbiota.
hoped
attention
these
individuals
will
continue
grow
progressively.
Molecules,
Год журнала:
2025,
Номер
30(8), С. 1672 - 1672
Опубликована: Апрель 8, 2025
Parkinson’s
disease
(PD)
is
a
complex
neurodegenerative
disorder
with
debilitating
non-motor
symptoms,
including
gastrointestinal
dysfunction,
cardiovascular
abnormalities,
mood
and
anxiety
disorders,
cognitive
decline,
sleep
disturbances,
respiratory
pain.
Despite
their
significant
impact
on
quality
of
life,
these
symptoms
are
often
inadequately
addressed.
Propolis
natural
bee-derived
product,
rich
in
bioactive
compounds
anti-inflammatory,
antioxidant,
immunomodulatory,
neuroprotective
properties,
which
holds
potential
PD
due
to
its
multitarget
multipathway
actions,
addressing
various
underlying
mechanisms
symptom
diseases.
Preclinical
clinical
studies
suggest
that
propolis
may
influence
key
pathological
PD’s
symptoms.
Evidence
points
benefits
improving
cognition,
health,
alleviating
sleep-related
issues.
Although
research
remains
scarce,
findings
from
related
conditions
ability
associated
This
review
underscores
the
underexplored
therapeutic
PD,
drawing
existing
evidence
advocating
for
further
fully
assess
role
patient
outcomes.
