The
viability,
productivity
and
survival
of
higher
plants
under
the
adverse
factors
influence
are
largely
determined
by
functional
activity
antioxidant
system.
aim
our
work
was
to
investigate
changes
in
formation
high-molecular
(superoxide
dismutase
peroxidase)
low-molecular
(phenolics,
including
flavanols
proanthocyanidins)
antioxidants
callus
culture
Camellia
sinensis
phenolic
precursors
(L-phenylalanine
–
3
mM,
trans-cinnamic
acid
1
naringenin
0.5
mM).
According
data
obtained,
effect
on
tea
cultures
did
not
lead
significant
increasing
superoxide
peroxidase
most
cases.
However,
it
led
increased
accumulation
total
phenolics
content,
as
well
proanthocyanidins
contents.
For
C.
cultures,
promising
regulator
compounds
L-phenylalanine,
presence
which
its
content
almost
twice.
Thus,
exogenous
various
is
possible
use
for
targeted
regulation
certain
classes
plant
cells.
Molecules,
Год журнала:
2024,
Номер
29(5), С. 1000 - 1000
Опубликована: Фев. 25, 2024
Quercetin
is
a
flavonoid
with
low
molecular
weight
that
belongs
to
the
human
diet’s
phenolic
phytochemicals
and
nonenergy
constituents.
has
potent
antioxidant
capacity,
being
able
capture
reactive
oxygen
species
(ROS),
nitrogen
(RNS),
chlorine
(ROC),
which
act
as
reducing
agents
by
chelating
transition-metal
ions.
Its
structure
five
functional
hydroxyl
groups,
work
electron
donors
are
responsible
for
capturing
free
radicals.
In
addition
its
different
pharmacological
properties
of
quercetin
have
been
described,
such
carcinostatic
properties;
antiviral,
antihypertensive,
anti-inflammatory
ability
protect
low-density
lipoprotein
(LDL)
oxidation,
inhibit
angiogenesis;
these
developed
in
this
review.
Quercetin
is
a
flavonoid
with
low
molecular
weight
that
belongs
to
the
human
diet's
phenolic
phytochemicals
and
non-energy
constituents.
has
potent
antioxidant
capacity,
being
able
capture
Reactive
Oxygen
Species
(ROS),
reactive
nitro-gen
species
(RNS),
Chlorine
(ROC),
which
act
as
reducing
agents
by
chelating
transition
metal
ions.
Its
structure
five
functional
hydroxyl
groups,
work
electron
donors
are
responsible
for
capturing
free
radicals.
In
addition
its
it
was
described
different
pharmacological
properties
of
Quercetin,
such
carcinostatic
properties,
antiviral,
antihypertensive,
anti-inflammatory,
protection
Low-Density
Lipoprotein
(LDL)
oxidation,
inhibi-tion
angiogenesis
developed
in
this
review.
Biomedicine & Pharmacotherapy,
Год журнала:
2023,
Номер
167, С. 115571 - 115571
Опубликована: Сен. 25, 2023
Colorectal
cancer
is
a
prevalent
malignant
tumor
with
complex
and
diverse
pathogenesis.
In
recent
years,
natural
products
have
shown
promising
application
prospects
as
sources
of
anticancer
drugs.
BBR,
class
benzoquinoline
alkaloids
extracted
from
various
plants,
widely
used
in
disease
treatments
owing
to
its
pharmacological
activities,
including
antibacterial,
anti-inflammatory,
antioxidant,
anticancer,
anti-angiogenesis
properties.
Research
has
demonstrated
that
BBR
exerts
an
anti-Salmonella
-Escherichia
coli
infection
effect,
attenuating
inflammatory
reactions
by
inhibiting
harmful
bacteria.
During
the
stage
colorectal
precancerous
lesions,
inhibits
activity
cell
cyclin
regulating
PI3K/AKT,
MAPK,
Wnt
signaling
pathways,
thereby
decelerating
cycle
progression
polyp
or
adenoma
cells.
Moreover,
inhibitory
effect
on
primarily
occurs
through
regulation
cycle,
anti-angiogenesis,
gut
microbiota,
antioxidant
pathways.
The
specific
involved
pathways
include
MPK/ERK,
NF-kB,
EGFR
encompassing
Bcl-2
family
proteins,
vascular
endothelial
growth
factor,
superoxide
dismutase.
This
study
reviews
summarizes,
for
first
time,
mechanisms
action
carcinogenesis
process
cancer,
providing
novel
insights
clinical
intestinal
diseases.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(3), С. 1744 - 1744
Опубликована: Фев. 1, 2024
Echinacea
purpurea
L.
(EP)
preparations
are
globally
popular
herbal
supplements
known
for
their
medicinal
benefits,
including
anti-inflammatory
activities,
partly
related
to
phenolic
composition.
However,
regarding
use
the
management
of
inflammation-related
intestinal
diseases,
knowledge
about
fate
orally
ingested
constituents
throughout
human
gastrointestinal
tract
and
exposition
in
vitro
digested
extracts
relevant
inflammatory
models
unknown.
This
study
investigated
first
time
impact
digestion
(INFOGEST)
on
composition
properties
EP
from
flowers
(EF),
leaves
(EL),
roots
(ER)
IL-1β-treated
colon-derived
CCD-18Co
cells.
Among
seven
hydroxycinnamic
acids
identified
using
HPLC-UV-MS/MS,
chicoric
caftaric
showed
highest
concentrations
EL,
followed
by
EF
ER,
all
exerted
significant
reductions
IL-6,
IL-8,
PGE2
levels.
After
digestion,
despite
reducing
bioaccessibility
phenolics,
effects
were
preserved
EL
and,
a
lesser
extent,
EF,
but
not
ER.
The
lower
content
ER
could
explain
these
findings.
Overall,
this
emphasizes
potential
alleviating
conditions
disorders.
BMC Veterinary Research,
Год журнала:
2025,
Номер
21(1)
Опубликована: Апрель 2, 2025
In
recent
years,
the
livestock
industry
has
shown
increasing
concern
regarding
need
to
find
effective
alternatives
antibiotic
products
while
also
striving
produce
high-quality
and
poultry
products.
Woody
feed
sources
exhibit
wide
distribution
variety,
containing
a
variety
of
bioactive
substances
such
as
flavonoids
alkaloids.
Among
these
woody
plants,
Neolamarckia
cadamba
(Nc)
characteristics
high
leaf
yield,
fast
growth
rate,
rich
nutritional
value,
which
great
development
potential.
However,
whether
Nc
supplementation
can
improve
performance,
immunity,
gut
health
yellow-feathered
broilers
remains
be
explored.
present
study,
we
aimed
investigate
effects
diet
supplemented
with
dry
powder
or
water
extract
on
intestinal
broilers.
The
results
showed
that,
(1)
There
was
no
significant
difference
in
Body
weight
(BW),
Average
daily
gain
(ADG),
intake
(ADFI),
Feed
conversion
ratio
(FCR)
between
experimental
groups
control
group
(P
>
0.05);
(2)
Compared
group,
thymus
index
at
63
days
significantly
increased
1%
<
0.05).
Conversely,
bursa
Fabricius
decreased
0.05)
same
group;
(3)
there
were
differences
serum
levels
albumin
(ALB),
globulin
(GLB),
total
protein
(TP),
alanine
aminotransferase
(ALT),
aspartate
(AST),
triglycerides
(TG)
each
(4)
IgG
both
0.05%
(5)
could
increase
mRNA
expression
ZO-1
TGF-β4
jejunum,
well
claudin-1,
ZO-1,
ileum(P
Furthermore,
use
resulted
jejunum
ileum
These
suggest
that
dietary
enhance
immune
function,
small
barrier
integrity,
reduce
inflammation
certain
extent.
four
doses
(1%
powder,
2%
0.1%
extract),
more
effective.
findings
underscore
importance
exploring
alternative
additives
production,
they
may
offer
viable
strategy
for
promoting
animal
performance
absence
traditional
antibiotics.
Molecules,
Год журнала:
2024,
Номер
29(2), С. 474 - 474
Опубликована: Янв. 18, 2024
The
viability,
productivity
and
survival
of
higher
plants
under
the
adverse
factors
influence
are
largely
determined
by
functional
activity
antioxidant
system.
aim
our
work
was
to
investigate
changes
in
formation
high-molecular
(superoxide
dismutase
peroxidase)
low-molecular
(phenolics,
including
flavanols
proanthocyanidins)
antioxidants
callus
culture
Camellia
sinensis
phenolic
precursors
(L-phenylalanine—3
mM,
trans-cinnamic
acid—1
naringenin—0.5
mM).
According
data
obtained,
effect
on
tea
cultures
did
not
lead
significant
increasing
superoxide
peroxidase
most
cases.
However,
it
led
increased
accumulation
total
phenolics
content,
as
well
proanthocyanidins
contents.
For
C.
cultures,
promising
regulator
compounds
L-phenylalanine,
presence
which
its
content
almost
twice.
Thus,
exogenous
various
is
possible
use
for
targeted
regulation
certain
classes
plant
cells.
Animals,
Год журнала:
2024,
Номер
14(4), С. 564 - 564
Опубликована: Фев. 7, 2024
The
dietary
supplementation
of
olive
oil
by-products,
including
mill
waste-water
(OMWW)
in
animal
diets,
is
a
novel
application
that
allows
for
their
re-utilization
and
recycling
could
potentially
decrease
the
use
antibiotics,
antimicrobial
resistance
risk
livestock
species,
occurrence
intestinal
diseases.
Salmonella
serovar
typhimurium
one
most
widespread
pathogens
world,
causing
enterocolitis
pigs.
aim
this
study
was
to
investigate
effect
an
OMWW
extract
enriched
polyphenols
(hydroxytyrosol
tyrosol)
immune
response
porcine
epithelial
cell
line
(IPEC-J2)
following
S.
infection.
Cells
were
pre-treated
with
OMWW-extract
(OMWW-EP,
0.35
1.4
µg)
24
h
then
infected
1
h.
We
evaluated
bacterial
invasiveness
assayed
IPEC-J2
gene
expression
RT-qPCR
cytokine
release
ELISA
test.
obtained
results
showed
OMWW-EP
(1.4
significantly
reduced
invasiveness;
µg
decreased
IL1B,
MYD88,
DEFB1
DEFB4A,
while
down-regulated
IL1B
DEFB4A
increased
TGFB1.
content
unchanged
cells.
This
first
demonstrating
vitro
immunomodulatory
activity
extracts
polyphenols,
suggesting
protective
role
on
pig
intestine
potential
as
feed
supplements
farm
animals
such
Life,
Год журнала:
2024,
Номер
14(11), С. 1450 - 1450
Опубликована: Ноя. 8, 2024
Anastomotic
leaks
remain
a
significant
challenge
in
intestinal
surgery,
often
leading
to
severe
complications.
This
study
investigated
novel
approach
enhance
anastomotic
healing
and
reduce
the
risk
of
by
combining
traditional
suturing
stapling
techniques
with
non-thermal
atmospheric
pressure
plasma
(NTAPP)
application.
NTAPP,
cold
generated
through
ionization
ambient
air,
has
been
shown
possess
antimicrobial,
hemostatic,
wound-healing
properties.
NTAPP
promotes
sterilization,
coagulation,
tissue
regeneration
generating
reactive
oxygen
nitrogen
species,
potentially
strengthening
union.
pilot
evaluated
efficacy
three
patients
undergoing
anastomosis.
Following
standard
surgical
procedure,
was
applied
directly
site.
Postoperative
outcomes
were
monitored
for
six
months,
including
rates.
Preliminary
results
demonstrated
promising
outcomes.
All
exhibited
successful
sealing
anastomosis,
no
evidence
leakage
during
follow-up
period,
providing
reassurance
confidence
potential
sutures,
staples,
NTAPP.
These
findings
suggest
that
can
significantly
improve
safety
surgeries
reducing
incidence
leaks.
While
further
research
larger
sample
is
necessary
confirm
these
initial
findings,
this
provide
strong
foundation
exploring
as
valuable
adjunct
conventional
preventing
innovative
could
postoperative
complications,
patient
outcomes,
overall
quality
care
surgery.
