Exposure of pregnant and lactating parental mice to aflatoxin B1 promotes hepatotoxicity in offspring mice
Bingxue Liu,
Shijie Xia,
Wen Xiao
и другие.
Archives of Toxicology,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 2, 2025
Язык: Английский
Protective Effects of Propolis Supplementation on Aflatoxin B1‐Induced Oxidative Stress, Antioxidant Status, Intestinal Barrier Damage, and Gut Microbiota in Rats
Molecular Nutrition & Food Research,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 30, 2025
ABSTRACT
Aflatoxin
B1
(AFB1)
is
common
in
the
diets
of
humans
and
animals
often
leads
to
adverse
health
effects.
Propolis,
with
its
strong
antioxidant
activity,
can
reduce
oxidative
stress
modulate
gut
microbiota
composition.
However,
underlying
mechanism
by
which
propolis
alleviates
AFB1‐induced
intestinal
barrier
damage
remains
unclear.
This
study
was
designed
investigate
protective
effects
oral
supplementation
AFB1‐exposed
rats.
Thirty‐two
male
Sprague‐Dawley
rats
were
divided
into
four
groups:
control,
AFB1,
propolis,
AFB1+propolis.
After
4
weeks,
serum
markers
examined,
analyzed
16S
rRNA
sequencing.
Intestinal
sections
processed
Hematoxylin
&
Eosin
staining,
expression
level
tight
junction
proteins
assessed
immunostaining.
Propolis
tended
decrease
stress,
it
also
restructured
preventing
a
relative
abundances
Lactobacillus
,
Roseburia
Phascolarctobacterium
.
restored
permeability
impaired
AFB1
ameliorating
morphological
increasing
levels
proteins.
may
contribute
modulation
alleviating
improving
Язык: Английский
The Detoxification Effects of Melatonin on Aflatoxin-Caused Toxic Effects and Underlying Molecular Mechanisms
Antioxidants,
Год журнала:
2024,
Номер
13(12), С. 1528 - 1528
Опубликована: Дек. 13, 2024
Aflatoxins
(AFTs)
are
a
form
of
mycotoxins
mainly
produced
by
Aspergillus
flavus
and
parasiticus,
which
common
contaminants
in
various
agricultural
sources
such
as
feed,
milk,
food,
grain
crops.
Aflatoxin
B1
(AFB1)
is
the
most
toxic
one
among
all
AFTs.
AFB1
undergoes
bioactivation
into
AFB1-8,9-epoxide,
then
leads
to
diverse
harmful
effects
neurotoxicity,
carcinogenicity,
hepatotoxicity,
reproductive
toxicity,
nephrotoxicity,
immunotoxicity,
with
specific
molecular
mechanisms
varying
different
pathologies.
The
detoxification
great
importance
for
safeguarding
health
animals
humans
has
increasingly
attracted
global
attention.
Recent
research
shown
that
melatonin
supplementation
can
effectively
mitigate
AFB1-induced
multiple
effects.
protection
involve
inhibition
oxidative
stress,
upregulation
antioxidant
enzyme
activity,
reduction
mitochondrial
dysfunction,
inactivation
apoptotic
pathway,
blockade
inflammatory
responses,
attenuation
cytochrome
P450
enzymes’
expression
activities.
In
summary,
this
review
sheds
new
light
on
potential
role
detoxifying
agent
against
AFB1.
Further
exploration
precise
clinical
efficacy
promising
treatment
urgently
needed.
Язык: Английский