The Detoxification Effects of Melatonin on Aflatoxin-Caused Toxic Effects and Underlying Molecular Mechanisms DOI Creative Commons
Chongshan Dai, Daowen Li, Tony Velkov

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(12), P. 1528 - 1528

Published: Dec. 13, 2024

Aflatoxins (AFTs) are a form of mycotoxins mainly produced by Aspergillus flavus and parasiticus, which common contaminants in various agricultural sources such as feed, milk, food, grain crops. Aflatoxin B1 (AFB1) is the most toxic one among all AFTs. AFB1 undergoes bioactivation into AFB1-8,9-epoxide, then leads to diverse harmful effects neurotoxicity, carcinogenicity, hepatotoxicity, reproductive toxicity, nephrotoxicity, immunotoxicity, with specific molecular mechanisms varying different pathologies. The detoxification great importance for safeguarding health animals humans has increasingly attracted global attention. Recent research shown that melatonin supplementation can effectively mitigate AFB1-induced multiple effects. protection involve inhibition oxidative stress, upregulation antioxidant enzyme activity, reduction mitochondrial dysfunction, inactivation apoptotic pathway, blockade inflammatory responses, attenuation cytochrome P450 enzymes’ expression activities. In summary, this review sheds new light on potential role detoxifying agent against AFB1. Further exploration precise clinical efficacy promising treatment urgently needed.

Language: Английский

Exposure of pregnant and lactating parental mice to aflatoxin B1 promotes hepatotoxicity in offspring mice DOI

Bingxue Liu,

Shijie Xia,

Wen Xiao

et al.

Archives of Toxicology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 2, 2025

Language: Английский

Citations

0
Protective Effects of Propolis Supplementation on Aflatoxin B1‐Induced Oxidative Stress, Antioxidant Status, Intestinal Barrier Damage, and Gut Microbiota in Rats DOI Creative Commons
Sevtap KÜÇÜKCANKURTARAN, Mehtap Ünlü Söğüt, Neslihan Öner

et al.

Molecular Nutrition & Food Research, Journal Year: 2025, Volume and Issue: unknown

Published: March 30, 2025

ABSTRACT Aflatoxin B1 (AFB1) is common in the diets of humans and animals often leads to adverse health effects. Propolis, with its strong antioxidant activity, can reduce oxidative stress modulate gut microbiota composition. However, underlying mechanism by which propolis alleviates AFB1‐induced intestinal barrier damage remains unclear. This study was designed investigate protective effects oral supplementation AFB1‐exposed rats. Thirty‐two male Sprague‐Dawley rats were divided into four groups: control, AFB1, propolis, AFB1+propolis. After 4 weeks, serum markers examined, analyzed 16S rRNA sequencing. Intestinal sections processed Hematoxylin & Eosin staining, expression level tight junction proteins assessed immunostaining. Propolis tended decrease stress, it also restructured preventing a relative abundances Lactobacillus , Roseburia Phascolarctobacterium . restored permeability impaired AFB1 ameliorating morphological increasing levels proteins. may contribute modulation alleviating improving

Language: Английский

Citations

0
The Detoxification Effects of Melatonin on Aflatoxin-Caused Toxic Effects and Underlying Molecular Mechanisms DOI Creative Commons
Chongshan Dai, Daowen Li, Tony Velkov

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(12), P. 1528 - 1528

Published: Dec. 13, 2024

Aflatoxins (AFTs) are a form of mycotoxins mainly produced by Aspergillus flavus and parasiticus, which common contaminants in various agricultural sources such as feed, milk, food, grain crops. Aflatoxin B1 (AFB1) is the most toxic one among all AFTs. AFB1 undergoes bioactivation into AFB1-8,9-epoxide, then leads to diverse harmful effects neurotoxicity, carcinogenicity, hepatotoxicity, reproductive toxicity, nephrotoxicity, immunotoxicity, with specific molecular mechanisms varying different pathologies. The detoxification great importance for safeguarding health animals humans has increasingly attracted global attention. Recent research shown that melatonin supplementation can effectively mitigate AFB1-induced multiple effects. protection involve inhibition oxidative stress, upregulation antioxidant enzyme activity, reduction mitochondrial dysfunction, inactivation apoptotic pathway, blockade inflammatory responses, attenuation cytochrome P450 enzymes’ expression activities. In summary, this review sheds new light on potential role detoxifying agent against AFB1. Further exploration precise clinical efficacy promising treatment urgently needed.

Language: Английский

Citations

0