Complex Interplay of Psychiatry Disorders, Fractures, and Osteoporosis: A Mendelian Randomization Study DOI Creative Commons

xueqiang wu,

zefang Li,

Han‐Zheng Li

и другие.

Research Square (Research Square), Год журнала: 2023, Номер unknown

Опубликована: Окт. 24, 2023

Abstract Background Neurodevelopmental disorders, such as Attention-Deficit/Hyperactivity Disorder (ADHD), Autism Spectrum (ASD), and Tourette Syndrome (TS), have been extensively studied for their multifaceted impacts on psychological, social, emotional well-being. Recently, there has growing interest in potential relationship with fracture risks adulthood. This study aims to explore the associations between these disorders rates, considering factors like self-harm impact of psychotropic medications. Methods Employing a novel approach, this utilized Mendelian randomization (MR) analysis investigate complex interplay ADHD, ASD, TS, fractures. The MR framework, leveraging extensive genomic datasets, facilitated systematic examination causal relationships genetic predispositions. Results findings unveil intriguing bidirectional links specific types Notably, ADHD is identified risk factor fractures, pronounced various anatomical regions, including skull, trunk, lower limbs. Conversely, individuals notably those affecting femur lumbar spine, exhibit an increased predisposition ASD. These results provide perspective neurodevelopmental emphasizing importance early diagnosis, intervention, holistic approach healthcare. Conclusion research sheds new light intricate connections offering valuable insights into links. fractures highlight need comprehensive clinical approaches that consider both psychological physical Early pharmacological interventions, diligent monitoring bone health are essential components improved healthcare strategies

Язык: Английский

Gut dysbiosis as a driver of neuroinflammation in attention-deficit/hyperactivity disorder: A review of current evidence DOI Creative Commons

Noëlle Lewis,

Anthony Villani, Jim Lagopoulos

и другие.

Neuroscience, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

There is mounting evidence for the involvement of immune system, neuroinflammation and disturbed gut microbiota, or dysbiosis, in attentive-deficit/hyperactivity disorder (ADHD). Gut dysbiosis strongly implicated many physical, autoimmune, neurological, neuropsychiatric conditions, however knowledge its particular pathogenic role ADHD sparse. As such, this narrative review examines synthesizes available related to inflammation, neural processes ADHD. Minimal differences microbiota diversity measures between cases controls were found, relative abundance observed at all classification levels (phylum strain). Compositional taxa important key gut-brain axis pathways, Bacteroides species Faecalibacterium, may contribute brain functioning differences, symptoms, We have identified one possible model etiopathogenesis involving systemic an impaired blood-brain barrier, disturbances as downstream consequences dysbiosis. Nevertheless, studies conducted date varied degrees methodological rigour involve diverse participant characteristics analytical techniques, highlighting a need additional research.

Язык: Английский

Процитировано

1
Bifidobacterium animalis subsp. lactis A6 attenuates hippocampal damage and memory impairments in an ADHD rat model DOI
Xindi Yin, Weichen Liu, Haihong Feng

и другие.

Food & Function, Год журнала: 2024, Номер 15(5), С. 2668 - 2678

Опубликована: Янв. 1, 2024

Bifidobacterium animalis subsp. lactis A6 ameliorated hippocampal damage and memory impairments in an ADHD rat model by reshaping the gut microbiota composition, alleviating neuron loss inflammation, regulating neurotransmitter release.

Язык: Английский

Процитировано

8
Mapping Theme Trends and Research Frontiers in Dexmedetomidine Over Past Decade: A Bibliometric Analysis DOI Creative Commons
Zheping Chen,

Zhenxiang Zuo,

Xinyu Song

и другие.

Drug Design Development and Therapy, Год журнала: 2024, Номер Volume 18, С. 3043 - 3061

Опубликована: Июль 1, 2024

Dexmedetomidine, an α

Процитировано

5
Dexmedetomidine improves clinical outcomes in sepsis-induced myocardial injury: a retrospective cohort study DOI Creative Commons
Yuan Liu, J. Ouyang, Cuicui Zhang

и другие.

Frontiers in Pharmacology, Год журнала: 2025, Номер 15

Опубликована: Янв. 15, 2025

The efficacy of dexmedetomidine (DEX) in treating sepsis-induced myocardial injury (SIMI) remains unclear. In this study, we explored the relationship between DEX use and clinical outcomes patients with SIMI, focusing on dosage treatment duration. retrospective cohort analysis, identified SIMI from Medical Information Mart for Intensive Care IV (MIMIC-IV) database categorized them into non-DEX groups based intensive care unit treatment. baseline bias was reduced through propensity score matching (PSM). primary outcome 28-day mortality, whereas secondary were in-hospital mortality rates at 7 days, 90 1 year. association assessed using Kaplan-Meier analysis Cox proportional hazards models. After PSM, 373 group matched 579 to achieve a balanced distribution covariates. regression model demonstrated significant reduction associated use, yielding hazard ratio (HR) 0.61 (95% confidence interval [CI]: 0.47-0.78, P < 0.001). In-hospital also significantly decreased (HR = 0.43, 95% CI: 0.33-0.57, Lower observed doses >0.4 μg/kg/h, particularly range 0.400-0.612 total >3.113 mg during hospitalization, durations exceeding 72 h improved risk all intervals. Regarding 28 our subgroup analyses indicated interaction Sequential Organ Failure Assessment invasive mechanical ventilation. administration year SIMI. These findings require validation future studies.

Язык: Английский

Процитировано

0
Effects of fecal microbiota transplantation on behavioral abnormality in attention deficit hyperactivity disorder-like model rats DOI Creative Commons

Wakana Harigai,

Koji Mikami, Mohammed E. Choudhury

и другие.

Journal of Pharmacological Sciences, Год журнала: 2025, Номер 157(3), С. 189 - 198

Опубликована: Янв. 27, 2025

Язык: Английский

Процитировано

0
The Role of Microbiome in Nervous and Immune System Development DOI
Hao Wang, Ji Young Lim, Qing Tang

и другие.

Elsevier eBooks, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0
Tetrahydroxy Stilbene Glucoside Alleviates ADHD Related Symptoms by Improving Neuroinflammation and BDNF Signaling Pathway:Bioinformatic Analysis and Experimental Verification DOI Creative Commons

Jichao Sun,

Xiaodong Huang, Xinmin Han

и другие.

Deleted Journal, Год журнала: 2025, Номер unknown, С. 200218 - 200218

Опубликована: Май 1, 2025

Язык: Английский

Процитировано

0
Complex interplay of neurodevelopmental disorders (NDDs), fractures, and osteoporosis: a mendelian randomization study DOI Creative Commons
Zefang Li, Xueqiang Wu,

Han‐Zheng Li

и другие.

BMC Psychiatry, Год журнала: 2024, Номер 24(1)

Опубликована: Март 27, 2024

Abstract Background Neurodevelopmental disorders (NDDs), such as Attention-Deficit/Hyperactivity Disorder (ADHD), Autism Spectrum (ASD), and Tourette Syndrome (TS), have been extensively studied for their multifaceted impacts on social emotional well-being. Recently, there has growing interest in potential relationship with fracture risks adulthood. This study aims to explore the associations between these rates, order facilitate better prevention treatment. Methods Employing a novel approach, this utilized Mendelian randomization (MR) analysis investigate complex interplay ADHD, ASD, TS, fractures. The MR framework, leveraging extensive genomic datasets, facilitated systematic examination of causal relationships genetic predispositions. Results findings unveil intriguing bidirectional links specific types Notably, ADHD is identified risk factor fractures, pronounced various anatomical regions, including skull, trunk, lower limbs. Conversely, individuals notably those affecting femur lumbar spine, exhibit an increased predisposition ASD. In research, no correlation was found TS or osteoporosis.These results provide perspective NDDs emphasizing importance early diagnosis, intervention, holistic approach healthcare. Conclusion research sheds new light intricate connections offering valuable insights into factors links. fractures highlight need comprehensive clinical approaches that consider both physical

Язык: Английский

Процитировано

2
Progress in the study of the correlation between sepsis and intestinal microecology DOI Creative Commons

Yan-Lin Tao,

Jing-Ran Wang, Miao Liu

и другие.

Frontiers in Cellular and Infection Microbiology, Год журнала: 2024, Номер 14

Опубликована: Сен. 26, 2024

Sepsis, a disease with high incidence, mortality, and treatment costs, has complex interaction the gut microbiota. With advances in high-throughput sequencing technology, relationship between sepsis intestinal dysbiosis become new research focus. However, owing to intricate interplay critical illness clinical interventions, it is challenging establish causal microbiota imbalance. In this review, correlation microecology was summarized, therapies for intervention based on microecological target therapy were proposed, shortcomings of bacterial selection application timing practice addressed. conclusion, current studies metabolomics, genomics other aspects aimed at continuously discovering potential probiotics are all providing theoretical basis restoring flora homeostasis subsequent sepsis.

Язык: Английский

Процитировано

2
GBA-related diseases and the application in Tourette syndrome treatment DOI Creative Commons

Jiaxuan Liao

Theoretical and Natural Science, Год журнала: 2024, Номер 33(1), С. 120 - 124

Опубликована: Март 7, 2024

This paper discusses the gut-brain axis (GBA) and how it takes part in various neurological diseases, including Alzheimers disease (AD), Attention-deficit hyperactivity disorder (ADHD), Tourette syndrome. The gut microbiota, inducing vital communications with brain through GBA, is not to be neglected maintaining physiological balance, potential become a source of new therapeutic opportunities for treating these diseases. Current studies show that methods such as personalized diets, oral bacteriotherapy, multi-strain probiotics like SLAB51 DEX have promising results AD ADHD manipulation biotas. Based on analysis previous research, this finds changes microbiota amount feces between healthy TS mice, particular decrease Firmicutes Actinobacteria, increase Bacteroidetes Proteobacteria. However, future experiments are required evaluate side effects microbiome alterations humans, treatments Tourettes syndrome based analysis. GBA area developing approaches research field holds great advancements treatment disorders currently no verified cures.

Язык: Английский

Процитировано

0