Complex Interplay of Psychiatry Disorders, Fractures, and Osteoporosis: A Mendelian Randomization Study DOI Creative Commons

xueqiang wu,

zefang Li,

Han‐Zheng Li

et al.

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: Oct. 24, 2023

Abstract Background Neurodevelopmental disorders, such as Attention-Deficit/Hyperactivity Disorder (ADHD), Autism Spectrum (ASD), and Tourette Syndrome (TS), have been extensively studied for their multifaceted impacts on psychological, social, emotional well-being. Recently, there has growing interest in potential relationship with fracture risks adulthood. This study aims to explore the associations between these disorders rates, considering factors like self-harm impact of psychotropic medications. Methods Employing a novel approach, this utilized Mendelian randomization (MR) analysis investigate complex interplay ADHD, ASD, TS, fractures. The MR framework, leveraging extensive genomic datasets, facilitated systematic examination causal relationships genetic predispositions. Results findings unveil intriguing bidirectional links specific types Notably, ADHD is identified risk factor fractures, pronounced various anatomical regions, including skull, trunk, lower limbs. Conversely, individuals notably those affecting femur lumbar spine, exhibit an increased predisposition ASD. These results provide perspective neurodevelopmental emphasizing importance early diagnosis, intervention, holistic approach healthcare. Conclusion research sheds new light intricate connections offering valuable insights into links. fractures highlight need comprehensive clinical approaches that consider both psychological physical Early pharmacological interventions, diligent monitoring bone health are essential components improved healthcare strategies

Language: Английский

Bifidobacterium animalis subsp. lactis A6 attenuates hippocampal damage and memory impairments in an ADHD rat model DOI
Xindi Yin, Weichen Liu, Haihong Feng

et al.

Food & Function, Journal Year: 2024, Volume and Issue: 15(5), P. 2668 - 2678

Published: Jan. 1, 2024

Bifidobacterium animalis subsp. lactis A6 ameliorated hippocampal damage and memory impairments in an ADHD rat model by reshaping the gut microbiota composition, alleviating neuron loss inflammation, regulating neurotransmitter release.

Language: Английский

Citations

7
Mapping Theme Trends and Research Frontiers in Dexmedetomidine Over Past Decade: A Bibliometric Analysis DOI Creative Commons
Zheping Chen,

Zhenxiang Zuo,

Xinyu Song

et al.

Drug Design Development and Therapy, Journal Year: 2024, Volume and Issue: Volume 18, P. 3043 - 3061

Published: July 1, 2024

Dexmedetomidine, an α

Citations

5
Effects of fecal microbiota transplantation on behavioral abnormality in attention deficit hyperactivity disorder-like model rats DOI Creative Commons

Wakana Harigai,

Koji Mikami, Mohammed E. Choudhury

et al.

Journal of Pharmacological Sciences, Journal Year: 2025, Volume and Issue: 157(3), P. 189 - 198

Published: Jan. 27, 2025

Language: Английский

Citations

0
Dexmedetomidine improves clinical outcomes in sepsis-induced myocardial injury: a retrospective cohort study DOI Creative Commons
Yuan Liu, J. Ouyang, Cuicui Zhang

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 15, 2025

The efficacy of dexmedetomidine (DEX) in treating sepsis-induced myocardial injury (SIMI) remains unclear. In this study, we explored the relationship between DEX use and clinical outcomes patients with SIMI, focusing on dosage treatment duration. retrospective cohort analysis, identified SIMI from Medical Information Mart for Intensive Care IV (MIMIC-IV) database categorized them into non-DEX groups based intensive care unit treatment. baseline bias was reduced through propensity score matching (PSM). primary outcome 28-day mortality, whereas secondary were in-hospital mortality rates at 7 days, 90 1 year. association assessed using Kaplan-Meier analysis Cox proportional hazards models. After PSM, 373 group matched 579 to achieve a balanced distribution covariates. regression model demonstrated significant reduction associated use, yielding hazard ratio (HR) 0.61 (95% confidence interval [CI]: 0.47-0.78, P < 0.001). In-hospital also significantly decreased (HR = 0.43, 95% CI: 0.33-0.57, Lower observed doses >0.4 μg/kg/h, particularly range 0.400-0.612 total >3.113 mg during hospitalization, durations exceeding 72 h improved risk all intervals. Regarding 28 our subgroup analyses indicated interaction Sequential Organ Failure Assessment invasive mechanical ventilation. administration year SIMI. These findings require validation future studies.

Language: Английский

Citations

0
Gut dysbiosis as a driver of neuroinflammation in attention-deficit/hyperactivity disorder: A review of current evidence DOI Creative Commons

Noëlle Lewis,

Anthony Villani, Jim Lagopoulos

et al.

Neuroscience, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

There is mounting evidence for the involvement of immune system, neuroinflammation and disturbed gut microbiota, or dysbiosis, in attentive-deficit/hyperactivity disorder (ADHD). Gut dysbiosis strongly implicated many physical, autoimmune, neurological, neuropsychiatric conditions, however knowledge its particular pathogenic role ADHD sparse. As such, this narrative review examines synthesizes available related to inflammation, neural processes ADHD. Minimal differences microbiota diversity measures between cases controls were found, relative abundance observed at all classification levels (phylum strain). Compositional taxa important key gut-brain axis pathways, Bacteroides species Faecalibacterium, may contribute brain functioning differences, symptoms, We have identified one possible model etiopathogenesis involving systemic an impaired blood-brain barrier, disturbances as downstream consequences dysbiosis. Nevertheless, studies conducted date varied degrees methodological rigour involve diverse participant characteristics analytical techniques, highlighting a need additional research.

Language: Английский

Citations

0
The Role of Microbiome in Nervous and Immune System Development DOI
Hao Wang, Ji Young Lim, Qing Tang

et al.

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
Complex interplay of neurodevelopmental disorders (NDDs), fractures, and osteoporosis: a mendelian randomization study DOI Creative Commons
Zefang Li, Xueqiang Wu,

Han‐Zheng Li

et al.

BMC Psychiatry, Journal Year: 2024, Volume and Issue: 24(1)

Published: March 27, 2024

Abstract Background Neurodevelopmental disorders (NDDs), such as Attention-Deficit/Hyperactivity Disorder (ADHD), Autism Spectrum (ASD), and Tourette Syndrome (TS), have been extensively studied for their multifaceted impacts on social emotional well-being. Recently, there has growing interest in potential relationship with fracture risks adulthood. This study aims to explore the associations between these rates, order facilitate better prevention treatment. Methods Employing a novel approach, this utilized Mendelian randomization (MR) analysis investigate complex interplay ADHD, ASD, TS, fractures. The MR framework, leveraging extensive genomic datasets, facilitated systematic examination of causal relationships genetic predispositions. Results findings unveil intriguing bidirectional links specific types Notably, ADHD is identified risk factor fractures, pronounced various anatomical regions, including skull, trunk, lower limbs. Conversely, individuals notably those affecting femur lumbar spine, exhibit an increased predisposition ASD. In research, no correlation was found TS or osteoporosis.These results provide perspective NDDs emphasizing importance early diagnosis, intervention, holistic approach healthcare. Conclusion research sheds new light intricate connections offering valuable insights into factors links. fractures highlight need comprehensive clinical approaches that consider both physical

Language: Английский

Citations

2
Progress in the study of the correlation between sepsis and intestinal microecology DOI Creative Commons

Yan-Lin Tao,

Jing-Ran Wang, Miao Liu

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2024, Volume and Issue: 14

Published: Sept. 26, 2024

Sepsis, a disease with high incidence, mortality, and treatment costs, has complex interaction the gut microbiota. With advances in high-throughput sequencing technology, relationship between sepsis intestinal dysbiosis become new research focus. However, owing to intricate interplay critical illness clinical interventions, it is challenging establish causal microbiota imbalance. In this review, correlation microecology was summarized, therapies for intervention based on microecological target therapy were proposed, shortcomings of bacterial selection application timing practice addressed. conclusion, current studies metabolomics, genomics other aspects aimed at continuously discovering potential probiotics are all providing theoretical basis restoring flora homeostasis subsequent sepsis.

Language: Английский

Citations

2
GBA-related diseases and the application in Tourette syndrome treatment DOI Creative Commons

Jiaxuan Liao

Theoretical and Natural Science, Journal Year: 2024, Volume and Issue: 33(1), P. 120 - 124

Published: March 7, 2024

This paper discusses the gut-brain axis (GBA) and how it takes part in various neurological diseases, including Alzheimers disease (AD), Attention-deficit hyperactivity disorder (ADHD), Tourette syndrome. The gut microbiota, inducing vital communications with brain through GBA, is not to be neglected maintaining physiological balance, potential become a source of new therapeutic opportunities for treating these diseases. Current studies show that methods such as personalized diets, oral bacteriotherapy, multi-strain probiotics like SLAB51 DEX have promising results AD ADHD manipulation biotas. Based on analysis previous research, this finds changes microbiota amount feces between healthy TS mice, particular decrease Firmicutes Actinobacteria, increase Bacteroidetes Proteobacteria. However, future experiments are required evaluate side effects microbiome alterations humans, treatments Tourettes syndrome based analysis. GBA area developing approaches research field holds great advancements treatment disorders currently no verified cures.

Language: Английский

Citations

0
A review on ADHD disorder, diagnosis and therapeutic approach in children and adolescents DOI Creative Commons
Gaurav Kumar, Bhawna Sharma, Raj K. Tiwari

et al.

Brain-Apparatus Communication A Journal of Bacomics, Journal Year: 2024, Volume and Issue: 3(1)

Published: Sept. 11, 2024

Language: Английский

Citations

0