Substance-Induced Psychiatric Disorders, Epigenetic and Microbiome Alterations, and Potential for Therapeutic Interventions
Brain Sciences,
Год журнала:
2024,
Номер
14(8), С. 769 - 769
Опубликована: Июль 30, 2024
Substance
use
disorders
(SUDs)
are
complex
biopsychosocial
diseases
that
cause
neurocognitive
deficits
and
neurological
impairments
by
altering
the
gene
expression
in
reward-related
brain
areas.
Repeated
drug
gives
rise
to
alterations
DNA
methylation,
histone
modifications,
of
microRNAs
several
areas
may
be
associated
with
development
psychotic
symptoms.
The
first
section
this
review
discusses
how
substance
contributes
symptoms
via
epigenetic
alterations.
Then,
we
present
more
evidence
about
link
between
SUDs
next
presents
associations
paternal
maternal
exposure
substances
brains
offspring
role
diet
preventing
substance-induced
impairments.
introduce
potential
therapeutic
agents/approaches
such
as
methyl-rich
diets
modify
for
alleviating
or
depression
SUDs.
Next,
discuss
use–gut
microbiome
interactions
contribute
through
gut
microbiome-derived
metabolites
become
new
therapeutics
normalizing
aberrations.
Finally,
address
possible
challenges
future
perspectives
patients
modulating
diets,
epigenome,
microbiome.
Язык: Английский
Cannabis use in youth is associated with chronic inflammation
Psychological Medicine,
Год журнала:
2024,
Номер
unknown, С. 1 - 11
Опубликована: Дек. 9, 2024
Abstract
Background
Markers
of
inflammation
and
cannabis
exposure
are
associated
with
an
increased
risk
mental
disorders.
In
the
current
study,
we
investigated
associations
between
use
biomarkers
inflammation.
Methods
Utilizing
a
sample
914
participants
from
Avon
Longitudinal
Study
Parents
Children,
whether
interleukin-6
(IL-6),
tumor
necrosis
factor
α
(TNF
),
C-reactive
protein
(CRP),
soluble
urokinase
plasminogen
activator
receptor
(suPAR)
measured
at
age
24
were
past
year
daily
use,
less
frequent
no
use.
We
adjusted
for
number
covariates
including
sociodemographic
measures,
body
mass
index,
childhood
trauma,
tobacco
smoking.
found
evidence
strong
association
or
near
suPAR.
Results
did
not
find
any
IL-6,
TNF
CRP,
Conclusions
Our
finding
that
is
strongly
suPAR,
biomarker
systemic
chronic
implicated
in
neurodevelopmental
neurodegenerative
processes
novel.
These
findings
may
provide
valuable
insights
into
biological
mechanisms
by
which
affects
brain
impacts
serious
Язык: Английский