Relation of serum BDNF to major depression and exploration of mechanistic roles of serum BDNF in a study of vitamin D3 and omega-3 supplements for late-life depression prevention

Journal of Psychiatric Research, Год журнала: 2023, Номер 163, С. 357 - 364

Опубликована: Май 26, 2023

Язык: Английский

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Mechanisms through which exercise reduces symptom severity and/or functional impairment in posttraumatic stress disorder (PTSD): Protocol for a living systematic review of human and non-human studies

Wellcome Open Research, Год журнала: 2023, Номер 8, С. 494 - 494

Опубликована: Окт. 25, 2023

Background Exercise can play an important role in reducing symptom severity and improving functional impairment patients with posttraumatic stress disorder (PTSD). However, the precise mechanisms underpinning effect of exercise PTSD management are not fully understood. This living systematic review aims to synthesize triangulate evidence from non-human human studies gain insight into biopsychosocial through which reduces impairment. Methods Independent searches will be conducted electronic databases identify eligible studies. Two reviewers independently conduct study selection, data extraction, risk bias assessment. We extract outcome variables that act as modifiers or mediators exercise. For studies, include equivalents clusters. primary severity. The secondary outcomes avoidance severity, reexperiencing hyperarousal negative cognitions mood impairment, loss diagnosis, dropout rates. To explain affects interest, we effects relate impact on potential mediating later outcomes. Comparison within-study direct indirect obtained mediation analysis, when reported, provide importance examined mediator. If appropriate, results using meta-analyses. examine total understand better symptoms function (when possible). about association between PTSD-related considered a consensus meeting sufficient is available. Protocol registration PROSPERO-ID: 453615

Язык: Английский

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A Pilot Study of the Role of the BDNF Val66Met Polymorphism in Response to Exercise-Augmented Exposure Therapy for Posttraumatic Stress Disorder

Psychoneuroendocrinology, Год журнала: 2024, Номер 167, С. 107106 - 107106

Опубликована: Июнь 21, 2024

Brain-Derived Neurotrophic Factor (BDNF) is implicated in extinction learning, which a primary mechanism of exposure therapy for posttraumatic stress disorder (PTSD). Brief aerobic exercise has been shown to promote BDNF release and augment learning. On the premise that Val allele Val66Met polymorphism facilitates greater BDNF, this study examined extent predicted treatment response PTSD patients who underwent combined with or passive stretching. (N = 85) provided saliva samples order extract genomic DNA identify Val/Val Met carriers genotype, were assessed severity prior following 9-week course The sample comprised 52 33 carriers. Patients high-expression display reduction symptoms at posttreatment than Hierarchical regression analysis indicated was specifically observed received combination exercise. This finding accords animal human evidence promotes these individuals may benefit more from exercise-augmented extinction. Although preliminary, result represents possible avenue augmented allele.

Язык: Английский

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Out with the bad, in with the good: A review on augmented extinction learning in humans

Neurobiology of Learning and Memory, Год журнала: 2024, Номер 215, С. 107994 - 107994

Опубликована: Окт. 18, 2024

Язык: Английский

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The impact of exercise interventions on sleep in adult populations with depression, anxiety, or posttraumatic stress: review of the current evidence and future directions

Journal of Behavioral Medicine, Год журнала: 2024, Номер unknown

Опубликована: Окт. 30, 2024

Язык: Английский

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