Modulation of social behavior by distinct vasopressin sources

Frontiers in Endocrinology, Год журнала: 2023, Номер 14

Опубликована: Фев. 13, 2023

The neuropeptide arginine-vasopressin (AVP) is well known for its peripheral effects on blood pressure and antidiuresis. However, AVP also modulates various social anxiety-related behaviors by actions in the brain, often sex-specifically, with typically being stronger males than females. nervous system originates from several distinct sources which are, turn, regulated different inputs regulatory factors. Based both direct indirect evidence, we can begin to define specific role of cell populations behavior, such as, recognition, affiliation, pair bonding, parental mate competition, aggression, stress. Sex differences function may be apparent sexually-dimorphic structures as ones without prominent structural within hypothalamus. understanding how systems are organized ultimately lead better therapeutic interventions psychiatric disorders characterized deficits.

Язык: Английский

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Ketogenic diet ameliorates autism spectrum disorders-like behaviors via reduced inflammatory factors and microbiota remodeling in BTBR T+ Itpr3tf/J mice

Experimental Neurology, Год журнала: 2023, Номер 366, С. 114432 - 114432

Опубликована: Май 5, 2023

Autism Spectrum Disorder (ASD) is increasing, but its complete etiology still lacking. Recently, application of ketogenic diet (KD) has shown to reduce abnormal behaviors while improving psychological/sociological status in neurodegenerative diseases. However, KD role on ASD and underlying mechanism remains unknown. In this work, administered BTBR T+ Itpr3tf/J (BTBR) C57BL/6J (C57) mice reduced social deficits (p = 0.002), repetitive < 0.001) memory impairments BTBR. Behavioral effects were related expression levels tumor necrosis factor alpha, interleukin-1β, interleukin-6 the plasma 0.007; p 0.001 0.023, respectively), prefrontal cortex 0.006; 0.04 0.03) hippocampus 0.02; 0.09 0.03). Moreover, accounted for oxidative stress by changing lipid peroxidation superoxide dismutase activity brain areas. Interestingly, increased relative abundances putatively beneficial microbiota (Akkermansia Blautia) C57 reversing increase Lactobacillus feces. Overall, our findings suggest that a multifunctional since it improved inflammatory plus together with remodeling gut-brain axis. Hence, may turn out be valuable therapeutic approach ameliorating ASD-like conditions even though more evidence required evaluate effectiveness especially long term.

Язык: Английский

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Serotonergic circuit dysregulation underlying autism-related phenotypes in BTBR mouse model of autism

Neuropharmacology, Год журнала: 2023, Номер 237, С. 109634 - 109634

Опубликована: Июнь 8, 2023

The inbred mouse strain, BTBR T+ Itpr3tf/J (BTBR), possesses neuronal and circuit abnormalities that underlie atypical behavioral profiles resembling the major symptoms of human autism spectrum disorder (ASD). Forebrain serotonin (5-HT) transmission has been implicated in ASD-related alterations. In this study, we assessed 5-HT signals functional responsiveness mice compared to standard C57BL/6J (B6) control elucidate how alterations contribute mice. A lower number neurons median raphe, but not dorsal was observed male female Acute systemic injection buspirone, a 5-HT1A receptor agonist, induced c-Fos several brain regions both B6 mice; however, blunted induction documented cingulate cortex, basolateral amygdala (BLA), ventral hippocampus (Hipp). Decreased responses these are associated with lack buspirone effects on anxiety-like behavior Analysis mRNA expression following acute indicated 5HTR1a gene downregulation (or upregulation) occurred BLA Hipp mice, respectively, factors neurogenesis or pro-inflammatory state consistently altered by injection. Therefore, responsivity via receptors linked behavior, which circuits disrupted Other distinct from regulate social restricted preserved

Язык: Английский

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Rapid Eye Movements in Sleep Furnish a Unique Probe into the Ontogenetic and Phylogenetic Development of the Visual Brain: Implications for Autism Research

Brain Sciences, Год журнала: 2025, Номер 15(6), С. 574 - 574

Опубликована: Май 26, 2025

With positron emission tomography followed by functional magnetic resonance imaging (fMRI), we demonstrated that rapid eye movements (REMs) in sleep are saccades scan dream imagery. The brain “sees” essentially the same way while awake and dreaming REM sleep. As expected, an event-related fMRI study (events = REMs) showed activation time-locked to REMs (“REM-locked” activation) oculomotor circuit controls saccadic visual attention. More crucially, provided a series of unexpected findings, including REM-locked multisensory integration. index processing endogenous information hierarchical generation imagery through neural processes concurrent with overlap extensively those reported be atypical autism spectrum disorder (ASD). Studies on ASD have shown integration, emerging early infancy subsequently developing into autistic symptoms. MRI studies infants at high risk for typically conducted during natural Simply timing may improve accuracy detection identify markers stratification heterogeneous patients. serve as task-free probe useful studying both animals, who cannot comply conventional tasks. Note REM-probe would easier implement because sleep, which is markedly preponderant last trimester pregnancy, still pronounced infancy. practice seeing world utero before birth. level attention across lifespan typical-atypical neurodevelopment. Longitudinal elucidate how develops ability “see” this goes awry autism. allow straightforward comparison animal human data. models great potential. This narrative review puts forth every reason believe employing development will far-reaching implications.

Язык: Английский

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Revisiting sociability: Factors facilitating approach and avoidance during the three-chamber test

Physiology & Behavior, Год журнала: 2023, Номер 272, С. 114373 - 114373

Опубликована: Окт. 5, 2023

The three-chamber test, the so-called sociability has been widely used to assess social deficits based on impaired socially oriented investigations in rodent models. An innate motivation for investigating conspecifics is theoretically a prerequisite gaining scores this paradigm. However, several relevant factors mediating investigatory motives, such as familiarity, attractiveness, and aggression, may affect scores, which must be verified obtain an adequate evaluation of psychiatric phenotypes exhibited by disease-relevant We assessed non-social that mediate proximity preference test with standard C57BL/6 J (B6) mice low BTBR+ltpr3tf/J (BTBR) mice. Strains opponents had no effect. Sexual cues (i.e., opposite sex) increased both strains mice; contrast, novel objects induced approach B6 but avoidance BTBR Single-housing before testing, stimulated motive, affected not females showed across sessions, males toward male stimulus, stimulus. was restored when stimulus anesthetized. In addition, self-grooming facilitated novelty strains. predominantly or stimuli, whereas recognized tended show avoidance. could evaluate approach-avoidance strategies target mouse comprise distance between

Язык: Английский

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The posterior intralaminar thalamic nucleus promotes nose‐to‐nose contacts leading to prosocial reception in the sequence of mouse social interaction

European Journal of Neuroscience, Год журнала: 2024, Номер 60(7), С. 5731 - 5749

Опубликована: Авг. 29, 2024

Efficient social interaction is essential for an adaptive life and consists of sequential processes multisensory events with counterparts. Social touch/contact a unique component that promotes sequence behaviours initiated by detection approach to assess stimulus subsequent form prosocial relationships. We hypothesized the thalamic sensory relay circuit from posterior intralaminar nucleus thalamus (pIL) paraventricular hypothalamus (PVN) medial amygdala (MeA) plays key role in contact-mediated events. found neurons pIL along PVN MeA were activated encounters activity was more abundant direct physical encounter, whereas dominant indirect through grid encounter. Chemogenetic inhibition selectively decreased investigatory sniffing same-sex, but not opposite-sex, mouse encounter situation facial/snout contact ratio setting. Furthermore, chemogenetic had no impact on anxiety-like or body coordinative motor behaviours, it impaired whisker-related plantar touch tactile sense. propose can sensations mediate nonsexual interactions thus significant establishing relationships models.

Язык: Английский

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THE ROLE OF GENE-ENVIRONMENT INTERACTIONS IN SOCIAL DYSFUNCTION: FOCUS ON PRECLINICAL EVIDENCE FROM MOUSE STUDIES

Neuropharmacology, Год журнала: 2024, Номер 261, С. 110179 - 110179

Опубликована: Окт. 5, 2024

Язык: Английский

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Oxytocin neurons in the paraventricular nucleus of the hypothalamus circuit-dependently regulates social behavior, which malfunctions in BTBR mouse model of autism

Research Square (Research Square), Год журнала: 2023, Номер unknown

Опубликована: Март 1, 2023

Oxytocin (OXT) a neuropeptide synthesized in the hypothalamic nuclei has variety of function including socio-emotional processes mammals. While neural circuits and signaling pathways central OXT converge paraventricular nucleus hypothalamus (PVN), we illuminate specific discrete PVN circuits, which connect to medial amygdala (MeA) bed stria terminalis (BnST) mouse models. The OXTPVN→BnST projections are innervated from entire portions PVN, while those OXTPVN→MeA asymmetrically posterior portion PVN. Compared with neurons B6 wild type mice, BTBR mice that recognized as behavior-based autism model exhibited defect projection. We demonstrate chemogenetic activation circuit enhances anxiety-like behavior facilitates social approach behavior, suppresses along inhibiting approach. This manipulation on proves ineffective mice. Accordingly, OXTPVN stimulate both induces receptor expressions MeA BnST by encounter induction genes was not observed These data support hypothesis serve regulator for control approach/avoidance contributes autism-like phenotypes

Язык: Английский

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The role of the posterior intralaminar thalamic nucleus on contact sequence in mouse social interaction

Authorea (Authorea), Год журнала: 2024, Номер unknown

Опубликована: Май 17, 2024

Efficient social interaction is essential for an adaptive life and consists of sequential processes multisensory events with counterparts. Social touch/contact a unique component that promotes sequence behaviors initiated by detection approach to assess stimulus subsequent maintenance touch/contacts form prosocial relationships. We hypothesized the thalamic sensory relay circuit from posterior intralaminar nucleus thalamus (pIL) paraventricular hypothalamus (PVN) medial amygdala (MeA) plays key role in contact-mediated events. found neurons pIL along PVN MeA, were activated encounters, activity was more abundant direct physical encounter, whereas MeA dominant indirect via grid encounter. Chemogenetic inhibition selectively decreased investigatory sniffing same-sex, but not opposite-sex, mouse encounter situation facial/snout contact ratio setting. Furthermore, chemogenetic had no impact on anxiety-like or body coordinative motor behaviors, it impaired whisker-related plantar touch tactile sense. propose can sensations mediate non-sexual interactions using through contact.

Язык: Английский

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Spatial Single-Cell Mapping of Transcriptional Differences Across Genetic Backgrounds in Mouse Brains

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Окт. 9, 2024

Abstract Genetic variation can alter brain structure and, consequently, function. Comparative statistical analysis of mouse brains across genetic backgrounds requires spatial, single-cell, atlas-scale data, in replicates—a challenge for current technologies. We introduce A tlas-scale T ranscriptome L ocalization using ggregate S ignatures (ATLAS), a scalable tissue mapping method. ATLAS learns transcriptional signatures from scRNAseq encodes them situ with tens thousands oligonucleotide probes, and decodes to infer cell types imputed transcriptomes. validated by comparing its type inferences direct MERFISH measurements marker genes quantitative comparisons four other Using ATLAS, we mapped the central five male female C57BL/6J (B6) mice BTBR T+ tf/J (BTBR) mice, an idiopathic model autism, collectively profiling over 40 million cells 400 coronal sections. Our revealed significant differences distributions identified 16 regional composition changes male-female B6-BTBR comparisons. thus enables systematic comparative studies, facilitating organ-level structure-function disease models.

Язык: Английский

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