Beyond Cholesterol: Emerging Risk Factors in Atherosclerosis
Journal of Clinical Medicine,
Год журнала:
2025,
Номер
14(7), С. 2352 - 2352
Опубликована: Март 29, 2025
Atherosclerosis
remains
a
leading
cause
of
cardiovascular
morbidity
and
mortality
worldwide,
traditionally
linked
to
elevated
cholesterol
levels,
particularly
low-density
lipoprotein
(LDL-C).
However,
despite
aggressive
lipid-lowering
strategies,
residual
risk
persists,
underscoring
the
need
explore
additional
contributing
factors.
This
review
examines
emerging
factors
beyond
cholesterol,
including
chronic
inflammation,
gut
microbiota
composition,
oxidative
stress,
environmental
exposures.
Inflammation
plays
pivotal
role
in
atherogenesis,
with
markers
such
as
C-reactive
protein
(CRP),
interleukin-6
(IL-6),
tumor
necrosis
factor-alpha
(TNF-α)
serving
indicators
disease
activity.
The
microbiome,
metabolites
like
trimethylamine
N-oxide
(TMAO),
has
been
implicated
vascular
inflammation
plaque
development,
while
beneficial
short-chain
fatty
acids
(SCFAs)
demonstrate
protective
effects.
Oxidative
stress
further
exacerbates
endothelial
dysfunction
instability,
driven
by
reactive
oxygen
species
(ROS)
lipid
peroxidation.
Additionally,
factors,
air
pollution,
heavy
metal
exposure,
endocrine
disruptors,
psychological
have
emerged
significant
contributors
disease.
Understanding
these
novel
offers
broader
perspective
on
atherosclerosis
pathogenesis
provides
new
avenues
for
targeted
prevention
therapeutic
interventions.
Язык: Английский
What is the best sampling region for endocrine hair analysis? A comparison between the posterior vertex and occipital region and recommendation for standardization.
Psychoneuroendocrinology,
Год журнала:
2025,
Номер
unknown, С. 107457 - 107457
Опубликована: Апрель 1, 2025
Язык: Английский
The effect of cortisol in early pregnancy on postpartum depressive symptoms
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Апрель 16, 2025
Abstract
The
first
months
after
childbirth
are
a
tremendous
challenge
for
women
and,
consequently,
time
when
women’s
mental
health
problems
often
arise.
Knowledge
of
the
prenatal
predictors
these
is
fundamental
importance
in
preventing
them.
This
study
aimed
to
test
whether
trimester
hair
cortisol
influenced
maternal
postpartum
depressive
symptoms.
(
N
=
75)
were
tested
twice:
pregnancy
and
within
three
giving
birth.
In
trimester,
they
had
samples
taken
examined
using
sociodemographic
survey
questionnaires:
Edinburgh
Postnatal
Depression
Scale
(EPDS),
Perceived
Stress
(PSS-10),
Zimbardo
Time
Perspective
Inventory.
After
delivery,
completed
about
course
delivery
their
child’s
health,
EPDS,
PSS-10.
Low
concentration
was
predictor
high
level
relationship
mediated
by
fatalistic
perspective.
results
suggest
that
low
indicates
probability
depression,
levels
may
be
associated
with
passivity,
sense
lack
control,
helplessness.
Язык: Английский