The effect of cortisol in early pregnancy on postpartum depressive symptoms DOI Creative Commons
Małgorzata Sobol,

Inna Hryhorchuk,

Elżbieta Plucińska

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 16, 2025

Abstract The first months after childbirth are a tremendous challenge for women and, consequently, time when women’s mental health problems often arise. Knowledge of the prenatal predictors these is fundamental importance in preventing them. This study aimed to test whether trimester hair cortisol influenced maternal postpartum depressive symptoms. ( N = 75) were tested twice: pregnancy and within three giving birth. In trimester, they had samples taken examined using sociodemographic survey questionnaires: Edinburgh Postnatal Depression Scale (EPDS), Perceived Stress (PSS-10), Zimbardo Time Perspective Inventory. After delivery, completed about course delivery their child’s health, EPDS, PSS-10. Low concentration was predictor high level relationship mediated by fatalistic perspective. results suggest that low indicates probability depression, levels may be associated with passivity, sense lack control, helplessness.

Language: Английский

Beyond Cholesterol: Emerging Risk Factors in Atherosclerosis DOI Open Access
Makhabbat Bekbossynova, Timur Saliev, T Ivanova-Razumova

et al.

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(7), P. 2352 - 2352

Published: March 29, 2025

Atherosclerosis remains a leading cause of cardiovascular morbidity and mortality worldwide, traditionally linked to elevated cholesterol levels, particularly low-density lipoprotein (LDL-C). However, despite aggressive lipid-lowering strategies, residual risk persists, underscoring the need explore additional contributing factors. This review examines emerging factors beyond cholesterol, including chronic inflammation, gut microbiota composition, oxidative stress, environmental exposures. Inflammation plays pivotal role in atherogenesis, with markers such as C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α) serving indicators disease activity. The microbiome, metabolites like trimethylamine N-oxide (TMAO), has been implicated vascular inflammation plaque development, while beneficial short-chain fatty acids (SCFAs) demonstrate protective effects. Oxidative stress further exacerbates endothelial dysfunction instability, driven by reactive oxygen species (ROS) lipid peroxidation. Additionally, factors, air pollution, heavy metal exposure, endocrine disruptors, psychological have emerged significant contributors disease. Understanding these novel offers broader perspective on atherosclerosis pathogenesis provides new avenues for targeted prevention therapeutic interventions.

Language: Английский

Citations

0
What is the best sampling region for endocrine hair analysis? A comparison between the posterior vertex and occipital region and recommendation for standardization. DOI Creative Commons

Katharina Huthsteiner,

Johannes B. Finke, Eva M.J. Peters

et al.

Psychoneuroendocrinology, Journal Year: 2025, Volume and Issue: unknown, P. 107457 - 107457

Published: April 1, 2025

Language: Английский

Citations

0
The effect of cortisol in early pregnancy on postpartum depressive symptoms DOI Creative Commons
Małgorzata Sobol,

Inna Hryhorchuk,

Elżbieta Plucińska

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 16, 2025

Abstract The first months after childbirth are a tremendous challenge for women and, consequently, time when women’s mental health problems often arise. Knowledge of the prenatal predictors these is fundamental importance in preventing them. This study aimed to test whether trimester hair cortisol influenced maternal postpartum depressive symptoms. ( N = 75) were tested twice: pregnancy and within three giving birth. In trimester, they had samples taken examined using sociodemographic survey questionnaires: Edinburgh Postnatal Depression Scale (EPDS), Perceived Stress (PSS-10), Zimbardo Time Perspective Inventory. After delivery, completed about course delivery their child’s health, EPDS, PSS-10. Low concentration was predictor high level relationship mediated by fatalistic perspective. results suggest that low indicates probability depression, levels may be associated with passivity, sense lack control, helplessness.

Language: Английский

Citations

0