Diagnostic modalities in the mediastinum and the role of bronchoscopy in mediastinal assessment: a narrative review DOI Open Access
Yonatan Dollin, Jaime A. Pineda,

Lily Sung

и другие.

Mediastinum, Год журнала: 2024, Номер 8, С. 51 - 51

Опубликована: Дек. 1, 2024

Diagnosis of pathology in the mediastinum has proven quite challenging, given wide variability both benign and malignant diseases that affect a diverse array structures. This complexity led to development many different non-invasive invasive diagnostic modalities. Historically, diagnosis relied on imaging modalities such as chest X-ray, computed tomography (CT), magnetic resonance imaging, positron emission topography. Once suspicious lesion was identified with one these techniques, gold standard for mediastinoscopy staging disease. More recently, minimally techniques CT-guided biopsy, endobronchial ultrasound transbronchial needle aspiration, endoscopic fine aspiration have revolutionized mediastinum. review provides comprehensive analysis all available diagnosing mediastinal disease an emphasis bronchoscopic techniques. Literature search performed via PubMed database. We included types articles study designs, including original research, meta-analyses, reviews, abstracts. Minimally ultrasound-transbronchial (EBUS-TBNA) ultrasound-fine (EUS-FNA) demonstrated high yield low complication rate made significant difference time lives patients. There continues be innovation field bronchoscopy new technologies confocal laser endomicroscopy, optical coherence tomography, artificial intelligence. Bronchoscopy is will continue integral modality

Язык: Английский

A Review of Endobronchial-Ultrasound-Guided Transbronchial Intranodal Forceps Biopsy and Cryobiopsy DOI Creative Commons
Michel Chalhoub,

Bino Joseph,

Sudeep Acharya

и другие.

Diagnostics, Год журнала: 2024, Номер 14(9), С. 965 - 965

Опубликована: Май 6, 2024

Benign and malignant mediastinal lesions are not infrequently encountered in clinical practice. Mediastinoscopy has long been considered the gold standard evaluating pathology. Since its introduction into practice, endobronchial-ultrasonography-guided transbronchial fine needle aspiration (EBUS-TBNA) replaced mediastinoscopy as initial procedure of choice to evaluate stage lung cancer. Its diagnostic yield benign less common malignancies, however, remained limited. This led different proceduralists investigate additional procedures improve EBUS-TBNA. In recent years, published reports concluded that addition EBUS-guided intranodal forceps biopsy (IFB) cryobiopsy (TBCB) EBUS-TBNA increases especially uncommon malignancies. The purpose this review is describe how EBUS-IFB EBUS-TBCB performed, compare their yields, discuss limitations potential complications. addition, will conclude with a proposed algorithm on incorporate

Язык: Английский

Процитировано

4
General Principles of Mediastinal Cryobiopsy DOI

Yong-Jia Qi,

Ye Fan

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0
Diagnostic value and safety of contact laser-assisted endobronchial ultrasound-guided tunnel drilling biopsy in mediastinal and hilar lymphadenopathy: a retrospective study DOI Creative Commons
Wenyu Zhan, Tian Wang, Changqing Yang

и другие.

Frontiers in Medicine, Год журнала: 2025, Номер 12

Опубликована: Янв. 30, 2025

Introduction Mediastinal and hilar lymphadenopathies are primarily diagnosed pathologically. Contact laser-assisted endobronchial ultrasound-guided tunnel drilling biopsy (EBUS-TDB), which uses a laser as tunneling incision tool, may yield more satisfactory specimens than conventional transbronchial needle aspiration (EBUS-TBNA), thereby improving the diagnostic yield. This study aims to evaluate value safety of contact EBUS-TDB compared EBUS-TBNA in assessment mediastinal lymph nodes. Methods retrospective included patients who presented our hospital between October 2022 April 2024 with or nodes short diameter ≥ 1 cm on computed tomography (CT) abnormally increased node metabolism positron emission (PET)-CT. All underwent both procedures successively. Results Overall, 278 were study, 244 cases confirmed. The rates ( p -values) for pulmonary extrapulmonary malignancies, lymphoma, sarcoidosis, tuberculosis 96.6% vs. 76.3% (0.043), 100% 67.7% (−), 88.9% 31.1% (0.555), 69.2% 30.8% (0.049), respectively. No serious adverse events occurred during after either procedure. Conclusion EBUS-TBNB demonstrates superior performance evaluation nodes, making it an alternative enhanced precision.

Язык: Английский

Процитировано

0
Cryobiopsies: Update on the Tools, Techniques, and Evidence for Malignancy, Interstitial Lung Diseases, and Lymph Nodes DOI

Felipe Aliaga,

Macarena R. Vial

Current Pulmonology Reports, Год журнала: 2025, Номер 14(1)

Опубликована: Фев. 25, 2025

Язык: Английский

Процитировано

0
Meta-analysis and systematic review of mediastinal cryobiopsy versus endobronchial ultrasound-transbronchial needle aspiration (EBUS-TBNA) in the diagnosis of intrathoracic adenopathy DOI Open Access
Roshen Mathew,

Winnie Elma Roy,

E Thomas

и другие.

Journal of Thoracic Disease, Год журнала: 2024, Номер 16(7), С. 4217 - 4228

Опубликована: Июль 1, 2024

Background: Endobronchial ultrasound (EBUS)-guided mediastinal/hilar cryobiopsy (MedCryoBx) is a relatively new modality, being combined with EBUS-transbronchial needle aspiration (TBNA) to improve yield in the diagnosis of intrathoracic adenopathy. This meta-analysis aims investigate diagnostic MedCryoBx versus EBUS-TBNA for Methods: We conducted systematic search using Google Scholar, Embase, and PubMed/MEDLINE studies about adenopathy EBUS-TBNA. Two authors separately reviewed inherent bias Quality Assessment Data Abstraction Synthesis-2 (QUADAS-2) tool. Inverse Variance weighting random effects methodology was used meta-analysis. Pooled yields overall subgroups were estimated. Complications reviewed. Results: Ten 844 patients undergoing either biopsy procedure final analysis. A total 554 underwent 704 Meta-analysis showed pooled 91% (504 554) 81% (567 704) EBUS-TBNA, odds ratio (OR) 2.5 [95% confidence interval (CI): 1.6 3.91; P<0.001], I2 20%. Subgroup analysis benign conditions increased OR 7.95 (91% 58% P<0.001) an 25%. lymphoma statistically significant increase 11.48 (87% 29% P=0.001). Mild bleeding (36.5%) without any intervention most common complication. Bleeding requiring (0.7%) noted patients. Pneumothorax (0.4%) pneumomediastinum less this Conclusions: very promising tool It has improved over possibly lymphoproliferative diseases, but so lung cancer. The complication rates are comparable

Язык: Английский

Процитировано

3
An explorative analysis on the optimal cryo-passes and freezing time of the ultrathin cryoprobe in endobronchial ultrasound-guided transbronchial mediastinal cryobiopsy DOI Creative Commons
Sze Shyang Kho, Shirin Hui Tan, Chun Ian Soo

и другие.

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Авг. 12, 2024

Abstract EBUS-guided transbronchial mediastinal cryobiopsy (TBMC) has emerged as a promising biopsy tool for diagnosing hilar and pathologies. However, several fundamental technical aspects of TBMC remain unexplored. This study aims to determine the optimal number cryo-passes freezing time ultrathin cryoprobe in EBUS-TBMC concerning specimen size procedural diagnostic yield. We conducted retrospective chart review patients with lesions who underwent between January 2021 April 2023 across three hospitals Malaysia. A total 129 procedures were successfully completed, achieving an overall yield 88.4%. Conclusive associated larger sizes (7.0 vs. 5.0 mm, p < 0.01). Specimen demonstrated positive correlation ( 0.01), plateauing at 4.1–6.0 mm. significant was also observed both 0.01) 0.05). Diagnostic plateaued after 2–3 cryo-passes. In contrast, longer times trended towards smaller specimens lower yield, though not reaching statistical significance. The highest recorded 3.1–4.0 s time. safety profile remains favourable, one case (0.8%) pneumothorax nine cases (7%) self-limiting bleeding. our cohort, performance achieve aggregate mm appeared optimal. Further prospective studies are needed validate these findings.

Язык: Английский

Процитировано

2
Combination of cryobiopsy with EBUS-TBNA–Might rapid on-site evaluation successfully drive patient selection? DOI Creative Commons
Michele Mondoni,

Momen M. Wahidi,

Giovanni Sotgiu

и другие.

Pulmonology, Год журнала: 2024, Номер 30(5), С. 416 - 418

Опубликована: Март 27, 2024

Язык: Английский

Процитировано

2
Additional yield of transbronchial cryo-node biopsy over endobronchial ultrasound-guided transbronchial needle aspiration for mediastinal lesions at a tertiary care center in India (COLD-FORCEPS-2 study) DOI Creative Commons
Manu Madan, Rohit Kumar, Pranav Ish

и другие.

Monaldi Archives for Chest Disease, Год журнала: 2024, Номер unknown

Опубликована: Июль 24, 2024

Endobronchial ultrasound (EBUS)-guided mediastinal cryobiopsy is a new modality for sampling lymph nodes. The data regarding the diagnostic yield and utility of still limited. Consecutive patients who were undergoing EBUS-guided transbronchial needle aspiration (EBUS-TBNA) recruited in this study. We subjected enrolled to after obtaining their informed consent. final diagnosis was made with clinical-pathological-radiological assessment clinical-radiological follow-up. A total 101 Adequacy achieved EBUS-TBNA 92.07%, compared 98.01% cryobiopsy. Diagnostic yields 67.32% 86.13%, respectively (p=0.001). EBUS patterns failed predict crobiopsy. No significant complications observed. To conclude, improves EBUS-TBNA.

Язык: Английский

Процитировано

1
Comments on “Comparative yield of transbronchial cryo-nodal biopsy, transbronchial intra-nodal forceps biopsy, and transbronchial needle aspiration for mediastinal lesions at a tertiary care center in India (COLD-FORCEPS study)” DOI Creative Commons
Vidushi Rathi

Monaldi Archives for Chest Disease, Год журнала: 2024, Номер unknown

Опубликована: Фев. 19, 2024

Dear Editor,The recent study by Madan et al. provides valuable information on the utility of intranodal cryobiopsy or forceps to endobronchial ultrasound - transbronchial needle aspiration (EBUS- TBNA) during sampling mediastinal lymph nodes. It found that cryoprobe acquires a larger tissue and increases diagnostic yield. However, increase in yield was statistically not significant...

Язык: Английский

Процитировано

0
Diagnostic value and safety of contact laser-assisted endotracheal ultrasound-guided tunnel drilling biopsy in mediastinal and hilar lymphadenopathy: a retrospective study DOI Creative Commons
Wenyu Zhan, Tian Wang, Changqing Yang

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Окт. 25, 2024

Abstract Background: Mediastinal and hilar lymphadenopathies are primarily diagnosed pathologically. Compared to traditional endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA), contact laser-assisted tunnel drilling biopsy (EBUS-TDB) using a laser as tunnelling incision tool may yield more satisfactory specimens, thereby improving the diagnostic yield. Therefore, this study aims evaluate value safety of EBUS-TDB compared EBUS-TBNA for mediastinal lymph nodes. Methods: This retrospective included patients who presented our hospital between October 2022 April 2024 with or nodes short diameter ≥ 1 cm on CT abnormally increased node metabolism PET-CT successively completed procedures. Results: Overall, 278 were in study, 244 cases confirmed. The rates (p-values) pulmonary extrapulmonary malignancies, lymphoma, sarcoidosis, tuberculosis 96.6% vs. 76.3% (0.043), 100% 67.7% (−), 88.9% 31.1% (0.555), 69.2% 30.8% (0.049), respectively. No serious adverse events occurred during after surgery. Conclusion: Contact EBUS-TBNB is superior diagnosis be used an alternative EBUS-TBNA.

Язык: Английский

Процитировано

0